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Artificial bones for recovering bone defects of osteoma and preparation method thereof

A technology for artificial bone and bone defect, applied in medical science, tissue regeneration, prosthesis, etc., to avoid sudden release of drugs, improve bone repair ability, and enhance the effect of artificial bone repair ability

Active Publication Date: 2019-09-17
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are only a few research reports on artificial bone loaded with cytotoxic chemotherapeutic drugs

Method used

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  • Artificial bones for recovering bone defects of osteoma and preparation method thereof
  • Artificial bones for recovering bone defects of osteoma and preparation method thereof
  • Artificial bones for recovering bone defects of osteoma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Composite powder preparation

[0032] (1) Mixing: Weigh PLLA and nHA at a ratio of 9:1, physically mix them, place them in a beaker filled with absolute ethanol, and disperse the mixture into a suspension by ultrasonic stirring. The particle size of the PLLA powder is 20-80μm, the viscosity is 1.8-2.5dL / g, the melting point is 170-185°C, the ultrasonic dispersion time is 30-60min, and the ultrasonic dispersion temperature is 40-60°C;

[0033] (2) Filtration: filter the suspension with a microporous membrane to obtain a mixed material;

[0034] (3) Drying: Dry the mixed material in a rotary dryer to obtain nHA / PLLA mixed powder. The drying temperature is 60-100°C. The mass percentage content of polylactic acid in the mixed powder is 90%, and the mass percentage content of hydroxyapatite is 10%.

[0035] 2. Selective laser sintering

[0036] (1) Preheating: spread the PLLA / nHA mixed powder on the laser sintering template, the thickness of each powder spreading is 0...

Embodiment 2

[0044] 1. Composite powder preparation

[0045] (1) Mixing: Weigh PLLA, nHA, and MET according to 9:1:2. After physical mixing, place them in a beaker filled with absolute ethanol, and disperse the mixture into a suspension by ultrasonic stirring. The particle size of the PLLA powder is 20-80μm, the viscosity is 1.8-2.5dL / g, the melting point is 170-185°C, the ultrasonic dispersion time is 30-60min, and the ultrasonic dispersion temperature is 40-60°C;

[0046](2) Filtration: filter the suspension with a microporous membrane to obtain a mixed material;

[0047] (3) Drying: Dry the mixed material in a rotary dryer to obtain MET / nHA / PLLA mixed powder. The drying temperature is 60-100°C. The mass percentage content of polylactic acid in the mixed powder is 75%, the mass percentage content of hydroxyapatite is 8.3%, and the mass percentage content of metformin is 16.7%.

[0048] 2. Selective laser sintering

[0049] (1) Preheating: Spread the MET / PLLA / nHA mixed powder on the l...

Embodiment 3

[0058] 1. Composite powder preparation

[0059] (1) Mixing: Weigh PLLA, nHA, and MET according to 9:1:4. After physical mixing, place them in a beaker filled with absolute ethanol, and disperse the mixture into a suspension by ultrasonic stirring. The particle size of the PLLA powder is 20-80μm, the viscosity is 1.8-2.5dL / g, the melting point is 170-185°C, the ultrasonic dispersion time is 30-60min, and the ultrasonic dispersion temperature is 40-60°C;

[0060] (2) Filtration: filter the suspension with a microporous membrane to obtain a mixed material;

[0061] (3) Drying: Dry the mixed material in a rotary dryer to obtain MET / nHA / PLLA mixed powder. The drying temperature is 60-100°C. The mass percentage content of polylactic acid in the mixed powder is 64.3%, the mass percentage content of hydroxyapatite is 7.1%, and the mass percentage content of metformin is 28.6%.

[0062] 2. Selective laser sintering

[0063] (1) Preheating: Spread the MET / PLLA / nHA mixed powder on th...

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Abstract

The invention discloses artificial bones for recovering bone defects of osteoma. The artificial bones are prepared from polylactic acid powder (PLA), hydroxyapatite powder (HA) and dimethylbiguanide powder (MET) according to mass ratios of (8 to 10) to 1 to (3 to 5). According to the artificial bones disclosed by the invention, by using dimethylbiguanide as a main effect increasing component, the aims of suppressing tumor cells and enhancing bone recovering ability are fulfilled, and the defect that the bone defects of the osteoma easily and locally recur, in particular to benign or borderline tumors such as giant cell tumors of bones is overcome; and meanwhile, because of excellent bone recovery performance, the challenge that self-recovery of massive bone defects is difficult after tumor excision is performed can be solved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an artificial bone for repairing tumor bone defects and a preparation method thereof. Background technique [0002] Tumor bone defect is a huge bone defect caused by surgery for benign and malignant bone tumors and other diseases, and faces great challenges of difficult repair and tumor recurrence. At present, the commonly used bone repair materials include autologous bone, allogeneic bone and artificial bone. Among them, the source of autologous bone is limited, and it causes secondary trauma to the bone harvesting site. Allograft bone has the risk of infection and disease, so artificial bone is an important choice. Hydroxyapatite (HA) has good compressive strength and excellent bone conduction properties. It is the main component of human bones. Polylactic acid (PLA) has excellent biocompatibility and degradation properties. Metformin can promote bone marrow mesenchymal stem ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61L27/58
CPCA61L27/46A61L27/54A61L27/58A61L2300/206A61L2300/416A61L2300/604A61L2430/02C08L67/04
Inventor 邓幼文谭伟帅词俊武明鑫孙进刘擎周小花
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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