2,3-dihydro-4(1H)- quinazolone derivative and application thereof

A quinazolone and derivative technology, which can be used in drug combinations, cardiovascular system diseases, respiratory system diseases, etc., and can solve the problems of poor tumor curative effect, toxic and side effects, etc.
CN101935318AInactive Publication Date: 2011-01-05SHANGAI PHARMA GRP CO LTD
1 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGAI PHARMA GRP CO LTD
Publication Date
2011-01-05
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a substituted 2,3-dihydro-4(1H)- quinazolone derivative shown in the formula I, pharmaceutically acceptable salt or solvate and a drug composite containing the same and application thereof. The compound has very good effect of restraining vascular endothelial cell proliferation. The compound, the pharmaceutically acceptable salt or solvate or the drug composite containing the same can be used for drugs requiring to restraining angiogenesis diseases and / or cytotoxicity exerting diseases.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention specifically relates to a 2,3-dihydro-4(1H)-quinazolone derivative, its pharmaceutically acceptable salt or solvate, and its pharmaceutical composition and application. Background technique

[0002] Angiogenesis is the process of generating new blood vessels from pre-existing vascular beds. Under normal circumstances, angiogenesis is strictly controlled in some transient, specific physiological processes, such as: reproductive process, developmental process and wound healing process. Sustained angiogenesis is the performance of certain diseases, such as: malignant growth of tumor tissue, diabetic retinopathy and so on.

[0003] Studies have shown that tumor is an angiogenesis-dependent disease, and the growth, invasion and metastasis of primary tumors all require the generation of new blood vessels. Neovascularization provides sufficient oxygen and nutrients for tumor cells, and its endothelial cells express a variety of growth ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More