Holothuria moebii saponin A, and preparation and application thereof

A technology of sea cucumber saponins and sea cucumber total saponins, which is applied in the field of medicine and can solve problems such as severe drug resistance, limited curative effect of glioma drugs, and hindering drug curative effect
CN104045682AInactive Publication Date: 2014-09-17ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2014-09-17
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides Holothuria moebii saponin A. The Holothuria moebii saponin A is prepared by separating total Holothuria moebii saponin from the marine invertebrate Holothuria moebii through percolation, extraction and reverse phase silica gel (ODS) column chromatography, then carrying out reverse phase silica gel column chromatographic separation and carrying out pressure-reduced concentration. The Holothuria moebii saponin A provided by the invention can substantially inhibit proliferation of a plurality of cells like rat brain glioma C6 and human brain glioma U87-MG, U251 and SHG-44, induce tumor cell apoptosis, reduce protein expression of a plurality of key enzymes in characteristic metabolism process of tumor cells and has a unique multi-target anti-glioma characteristic. Thus, the Holothuria moebii saponin A can be applied in preparation of drugs used for treating brain glioma. The chemical structural formula of the Holothuria moebii saponin A is described in the specification.
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Description

technical field

[0001] The invention belongs to the field of medicine, and relates to Moebioside A (Moebioside A), and sea cucumber Moebioside A obtained from marine invertebrates (Moebioside A) Holothuria moebii ) in the method for preparing the anti-tumor active compound Moebioside A (Moebioside A) and its application in the preparation of medicaments for treating glioma. Background technique

[0002] Glioma (glioma) is the most common and malignant brain tumor in the brain, accounting for about 46% of intracranial tumors and 70% of all malignant brain tumors. Statistics from the World Health Organization show that malignant glioma is the second cause of death for tumor patients under the age of 34, and the third cause of death for patients aged 35 to 54, seriously endangering human health and life. Combining radiotherapy and temozolomide chemotherapy after surgery is the most common method for the treatment of malignant glioma. For newly diagnosed patients, temozolomide...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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