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Medical Definition of reproduction. : the act or process of reproducing; specifically : the process by which plants and animals give rise to offspring and which fundamentally consists of the segregation of a portion of the parental body by a sexual or an asexual process and its subsequent growth and differentiation into a new individual.
Construction method and application of uterine-specific ctcf knockout-based infertility animal model
The application belongs to the technical field of genetic engineering, and discloses a uterus-specific Ctcf Construction method and application of an infertility animal model based on uterus-specific knockout. The research results show that CTCF deletion leads to complete loss of fertility in mice, which is manifested as implantation failure and blocked decidualization response. Unlike the embryonic lethality caused by systemic CTCF knockout, the uterus-specific knockout strategy mediated by Pgr-Cre successfully avoids the problem of early death, making it possible to study the function of CTCF in the adult uterus. The model provides an ideal tool for studying the physiological function of CTCF in the female reproductive process. In addition, the model shows a clear and stable infertility phenotype, and can be used as a platform for screening fertility drugs or studying decidualization mechanisms.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY