High-strength mineralized hydrogel and applications of high-strength mineralized hydrogel in bone repair

A hydrogel, high-strength technology, applied in medical science, tissue regeneration, prosthesis, etc., to achieve the effect of improving osseointegration and bone repair ability, good tensile and compressive properties

Inactive Publication Date: 2018-10-23
TIANJIN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

(Xu, B.; Zheng, P.; Gao, F.; Wang, W.; Zhang, H.; Zhang, X.; Feng, X.; Liu, W.A Mineralized High Strength and Tough Hydrogel for Skull BoneRegeneration. Adv. .Funct.Mater.2017,27,1604327.) However, unlike 2D bone defects, simple and effective 3D bone defect repair methods are still rarely reported

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  • High-strength mineralized hydrogel and applications of high-strength mineralized hydrogel in bone repair
  • High-strength mineralized hydrogel and applications of high-strength mineralized hydrogel in bone repair
  • High-strength mineralized hydrogel and applications of high-strength mineralized hydrogel in bone repair

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Embodiment Construction

[0025] The technical solutions of the present invention will be further described below in conjunction with specific embodiments. The medicines and instruments used in the embodiments of the present invention are commercially available or conventional medicines and equipment used in laboratories. N-acryloyl glycinamide is prepared from acryloyl chloride and glycinamide according to references, and will not be repeated here. See Dai, X.; Zhang, Y.; Gao, L.; Bai, T.; Wang, W.; Cui, Y.; Liu, W.A Mechanically Strong, Highly Stable, Thermoplastic, and Self-Healable Supramolecular Polymer Hydrogel. Adv. Mater. 2015, 27, 3566-3571.

[0026]Add monomer N-acryloyl glycinamide (225 mg), vinylphosphonic acid (25 mg, 25 μl, Sigma) into a 4ml centrifuge tube, dissolve with 750 μl of water and add 2.5 μl of photoinitiator IRGACURE-1173 (2- Hydroxy-2-methyl-1-phenyl-1-propanone, 98%, Sigma). The solvent containing monomer and initiator was injected into a tubular mold (inner diameter 1 mm,...

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Abstract

The invention discloses a high-strength mineralized hydrogel and applications of the high-strength mineralized hydrogel in bone repair. According to the present invention, N-acryloyl glycinamide and vinylphosphonic acid are used as raw materials and are co-polymerized in the presence of an initiator to prepare a hydrogel, calcium ions and phosphorus ions are deposited in situ in the gel to form hydroxyapatite, the mineralized hydrogel pipe has good tensile performance and good compressive performance due to the physical cross-linking effect of the hydrogen bond and the ion cross-linking effectof the hydroxyapatite and the gel matrix in the gel structure, and due to the presence of hydroxyapatite, the osseointegration and bone repair ability of the gel pipe is improved.

Description

technical field [0001] The invention relates to the preparation of a high-strength mineralized hydrogel tube with volumetric bone repair capacity, specifically a tubular N-acryloylglycylamide-vinylphosphonic acid-hydroxyapatite (P(NAGA-VPA ) / HAp) hydrogel preparation method and its application in volumetric bone repair, the hydrogel tube introduces hydroxyapatite inorganic particles into the gel matrix by in-situ precipitation method, so that the gel has the Combined and volumetric bone repair capacity. Background technique [0002] Today, there is still a lack of a simple and effective treatment for volumetric bone defects that cannot heal on their own. To solve this problem, many bone-like bioactive materials have been applied to repair volumetric bone defects, among which, as a material widely used in organisms, injectable hydrogel provides a solution for volumetric bone repair. However, due to its poor mechanical strength, the application of injectable hydrogel in volu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L35/00C08K3/32C08J3/075C08F222/38C08F230/02A61L27/52A61L27/16A61L27/12
CPCA61L27/12A61L27/16A61L27/52A61L2430/02C08F222/38C08J3/075C08J2335/00C08K3/32C08L35/00C08F230/02
Inventor 刘文广张絮然
Owner TIANJIN UNIV
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