The invention discloses an oxygen production system and method and an oxygen production machine. The oxygen production system comprises an air inlet, an air inlet filter, a compressor, an air inlet silencer, a heat dissipation and water removal device, an integrated adsorption tower, an oxygen flow mete, a bacterial filter, a humidification bottle and an oxygen outlet which are sequentially connected with one another, wherein the integrated adsorption tower and the heat dissipation and water removal device are respectively connected with an air outlet silencer. The oxygen production system also comprises a treatment device, wherein the treatment device is respectively and electrically connected with an air inlet filter, the air inlet silencer, the compressor, the heat dissipation and water removal device, the integrated adsorption tower, the air outlet silencer and the bacterial filter. The oxygen production machine comprises the oxygen production system. The structure is simple, automatic operation and closure of each part can be realized through control of a controller, the degree of automation is high, and high-concentration and sterile oxygen is effectively output.