The invention relates to the technical field of denitration catalysts, and discloses a high
alkali metal /
alkaline earth metal resistant denitration catalyst, which comprises a carrier, a modified substance, an active substance and a cocatalyst, wherein the active substance and the cocatalyst are loaded on the carrier to protect the carrier, so that the carrier has high
alkali metal /
alkaline earth metal poisoning resistance; the carrier is TiO2 nanoparticles, the modified substance is Ce ions, and the active substance and the cocatalyst are
transition metal oxides; according to the
mass ratio of the
metal to the carrier, the loading capacities of the modified substance, the active substance and the cocatalyst are all 3%-30%. The TiO2 nano-particles are modified, so that the TiO2 nano-particles have excellent
alkaline earth metal / high
alkali metal poisoning resistance and are suitable for
flue gas denitration treatment of a
coal-fired power
plant, the denitration efficiency is greatly improved, the service life is greatly prolonged, the production efficiency is improved, the replacement cost of the catalyst is reduced, and the preparation method of the catalyst is simple, safe and easy to operate.