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Aretificial nerve canula material of slow operating complex type poly lactic acid and preparation method

A technology of artificial nerve and polylactic acid, applied in medical science, prosthesis, etc.

Inactive Publication Date: 2005-01-12
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no reports in domestic and foreign literature on the use of multiple composite materials such as polylactic acid, nano-hydroxyapatite and nerve growth factor to prepare nerve conduits.

Method used

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  • Aretificial nerve canula material of slow operating complex type poly lactic acid and preparation method
  • Aretificial nerve canula material of slow operating complex type poly lactic acid and preparation method
  • Aretificial nerve canula material of slow operating complex type poly lactic acid and preparation method

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Embodiment 1

[0028] 1. PLA Preparation

[0029] The indirect method is used to form PDLLA from lactic acid polymerization dehydration and lactide ring-opening polymerization. The main chemical reaction process is as follows:

[0030]

[0031] The main steps include:

[0032] (1) Preparation of Lactide

[0033] The content is 85wt% D, L-lactic acid is used as the basic raw material, anhydrous zinc oxide is used as the catalyst, the temperature is raised to 130° C., and the water is evaporated by a water pump under reduced pressure. Then rapidly raise the temperature to 230°C, distill under reduced pressure with an oil pump, wash the distilled fraction with ethyl acetate and recrystallize to obtain pure D, L-lactide.

[0034] (2) Ring-opening polymerization of D, L-lactide

[0035] Weigh an appropriate amount of D, L-lactide obtained in step (1) and place it in a clean ampoule, and then inject D, L-lactide mass of 0.3‰ stannous octoate in chloroform as an initiator. Vacuum with a mech...

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Abstract

A slowly-releasing artificial nerve canal for repairing nerve is prepared through dissolving the bio absorptive polylactic acid in organic solvent adding hydroxy apatite nanoparticles and freeze-dried nerve growth factor (NGF) powder, ultrasonic dispersing and volatilizing solvent to obtain milliporous canal.

Description

technical field [0001] The invention relates to a composite slow-release artificial nerve guide material and preparation technology for repairing and regenerating human nerve damage. Background technique [0002] Peripheral nerve injuries and defects are common in clinical practice, so far, the therapeutic effect is not satisfactory. How to improve the curative effect is still an important issue that needs further research. [0003] The main problems affecting nerve repair and regeneration are limited sources of transplanted nerves, damage to the donor site, slow nerve regeneration, and poor regeneration quality. There have been many studies on nerve substitutes in the past, including autologous blood vessels, muscles, tendons, fascia, and synthetic non-absorbable and absorbable nerve bridge catheters. These materials and methods have achieved different therapeutic effects in animal experiments, and some materials have been used in clinical research reports. But in genera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04C08G63/08
Inventor 阎玉华万涛徐年华李世普王友法陈晓明贾莉殷湘慧
Owner WUHAN UNIV OF TECH
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