Method of establishing nano organic silane dressing layer on hydroxy apatite surfac

A hydroxyapatite, nano-organic technology, applied in medical science, prosthesis and other directions, can solve the problems of difficult to control the thickness of the coating layer, fast reaction speed, fast strength loss and so on

Inactive Publication Date: 2004-02-18
WUHAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage is that this type of composite material loses strength quickly in the physiological environment, and the first place to degrade is often located at the two-phase interface of hydroxyapatite and polymer.
Existing silane modification methods are carried out in proton systems, mostly in water or water-ethanol systems. In such systems, silanes are easily hydrolyzed to form polysiloxane coatings, and the reaction speed is relatively fast. Cladding thickness is difficult to control

Method used

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  • Method of establishing nano organic silane dressing layer on hydroxy apatite surfac
  • Method of establishing nano organic silane dressing layer on hydroxy apatite surfac

Examples

Experimental program
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Effect test

example 1

[0018] Example 1. Add 100 parts of hydroxyapatite micropowder (15-25 μm) into dry toluene under magnetic stirring, reflux under nitrogen protection for 0.5 hours, then add 2 parts of γ-aminopropyltriethoxysilane dropwise, and continue to reflux React for 12 hours; cool and centrifuge the reaction mixture, wash the precipitate three times with chloroform and absolute ethanol successively, dry at room temperature for 8 hours, and then dry in vacuum at 50° C. for 24 hours. According to the X-photoelectron spectroscopy (XPS) results, the thickness of the silane-modified layer is 1.8nm.

[0019] The calculation method is as follows:

[0020] Calcium atomic percentage (Ca Atom%) on the surface of unmodified hydroxyapatite: 18.6%, and the (maximum) thickness Th of the hydroxyapatite layer scanned by XPS at this time max = 10nm; and the calcium atomic percentage Ca Atom% on the surface of γ-aminopropyl triethoxysilane modified hydroxyapatite scanned by XPS is 15.2%, and the thickness...

example 2

[0021] Example 2. Add 100 parts of hydroxyapatite micropowder (15 to 25 μm) into dry N, N-dimethylformamide under magnetic stirring, reflux under nitrogen protection for 0.5 hour, then drop 2 parts of γ-(methyl Acryloyloxy)propyltrimethoxysilane, continue the reflux reaction for 13 hours; cool and centrifuge the reaction mixture, wash the precipitate with chloroform and absolute ethanol three times in turn, dry at room temperature for 8 hours, and then vacuum dry at 50°C 24 hours. According to the X-photoelectron spectroscopy (XPS) results, the thickness of the silane-modified layer was obtained by the same method as 2.7 nm.

example 3

[0022] Example 3. Add 100 parts of hydroxyapatite micropowder (15 to 25 μm) into dry N, N-dimethylformamide under magnetic stirring, reflux under nitrogen protection for 0.5 hours, then dropwise add 1 part of γ-(methyl Acryloyloxy)propyltrimethoxysilane, continue the reflux reaction for 14 hours; cool and centrifuge the reaction mixture, wash the precipitate with chloroform and absolute ethanol three times in turn, dry at room temperature for 8 hours, and then vacuum dry at 50°C 24 hours. According to the X-photoelectron spectroscopy (XPS) results, the thickness of the silane-modified layer obtained by the above method was 1.6 nm.

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Abstract

A process for preparing a nano-class decorative organic silane layer on the surface of hydroxyphosphorite features use of non-protonic system as solvent and includes reflux in solvent, reaction, centrifugal separation, washing and drying. Its advantages are high decorative effect and controllable thickness (1.5-2.7 nm).

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for modifying the surface of hydroxyapatite so as to create a nano-scale organosilane modification layer on the surface. technical background [0002] Hydroxyapatite (HA) is widely used as artificial synthetic bone substitute material due to its good biocompatibility and osseointegration ability. However, pure hydroxyapatite is relatively brittle, and it was mainly used in non-bearing small implants in the past, such as artificial tooth roots, ear bones, coatings, and bone defect filling materials. At present, a new important application direction of hydroxyapatite is to use hydroxyapatite powder or particles to strengthen and toughen absorbable polymers to form hydroxyapatite / absorbable polymers (such as poly α-hydroxy acid, etc.) As an alternative material, its polymer part is bioabsorbable, non-toxic, and easy to excrete. The hydroxyapatite in the comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12
Inventor 张胜民高东坡
Owner WUHAN UNIV OF TECH
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