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Method for synthesizing NANO hydroxyapatite

A technology of nano-hydroxyapatite and synthesis method, which is applied in the direction of phosphorus compounds, chemical instruments and methods, inorganic chemistry, etc., and can solve the problem that the shape, size and agglomeration degree of nano-hydroxyapatite cannot be strictly and effectively controlled, and nano-hydroxyphosphorus Limestone application limitations, high reaction temperature and other issues

Inactive Publication Date: 2006-04-19
JIANGSU UNIV
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Problems solved by technology

Guo Dagang et al [3] Short rod-shaped nano-hydroxyapatite particles with a diameter of about 10-20nm and a length of about 30-40nm were prepared by a simple wet synthesis, which further reduced the particle size, but it was still impossible to strictly and effectively control the shape of nano-hydroxyapatite. The size and degree of agglomeration, and the reaction temperature is high, and the reaction conditions are not easy to control, which greatly limits the application of nano-hydroxyapatite

Method used

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  • Method for synthesizing NANO hydroxyapatite
  • Method for synthesizing NANO hydroxyapatite
  • Method for synthesizing NANO hydroxyapatite

Examples

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Embodiment 1

[0029] Such as figure 1 , measure 35mL of 1.0mol / L Ca(NO 3 ) 2 4H 2 O, added to a three-necked flask placed in a constant temperature water bath at 40°C, and then added 1.76 grams of trisodium citrate; stirred and added dropwise 35 mL of 0.6 mol / L H 3 PO 4 . use NH 3 ·H 2 O adjusted the pH of the reaction solution to 10, and stirred at constant temperature for 4 hours. Afterwards, the solution was added into a stainless steel hydrothermal synthesis kettle lined with polytetrafluoroethylene and reacted at 200° C. for 8 hours. After the reaction, a milky white precipitate was obtained. The white precipitate was suction filtered and washed to obtain rod-shaped hydroxyapatite with an average diameter and length of 14 and 34 nm, respectively.

Embodiment 2

[0031] Such as figure 2 , measure 35mL of 1.0mol / L Ca(NO 3 ) 2 4H 2 O, put it into a three-neck flask placed in a constant temperature water pot at 60°C, and then add 5.27 grams of sodium dodecylsulfonate; stir and add 35 mL of 0.6mol / L H 3 PO 4 . use NH 3 ·H 2 O adjusted the pH of the reaction solution to 11, and stirred at constant temperature for 6 hours. Afterwards, the solution was added into a stainless steel hydrothermal synthesis kettle lined with polytetrafluoroethylene and reacted at 200° C. for 10 hours. After the reaction, a milky white precipitate was obtained. The white precipitate was suction filtered and washed to obtain rod-shaped hydroxyapatite with an average diameter and length of 22 and 51 nm, respectively.

Embodiment 3

[0033] Such as image 3 , measure 35mL of 1.0mol / L Ca(NO 3 ) 2 4H 2 O, add 10.54 grams of sodium dodecylbenzenesulfonate to a three-necked flask placed in a constant temperature water pot at 100°C; stir and add 35m of 0.6mol / L H 3 PO 4 . use NH 3 ·H 2 O adjusted the pH of the reaction solution to 13, stirred at constant temperature for 8 hours, and then added the solution into a stainless steel hydrothermal synthesis kettle lined with polytetrafluoroethylene and reacted at 200°C for 12 hours. After the reaction, a milky white precipitate was obtained. The white precipitate was suction-filtered and washed to obtain rod-shaped hydroxyapatite with an average diameter and length of 19 and 47 nm, respectively.

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Abstract

A process for synthesizing nano-class hydroxy apatite includes such steps as dissolving the organic compound containing carboxy, hydroxy and sulfonyl in the aqueous solution of Ca(NO3)2*4H2O at 40-100 deg.C, proportionally dripping H3PO4, regulating pH=10 or more, reaction for at least 4 hr, reaction at 40-200 deg.C for at least 8 hr, filter, washing and drying.

Description

technical field [0001] The invention relates to a method for preparing nanomaterials, in particular to a method for preparing nano-hydroxyapatite at different reaction temperatures by adding organic compounds containing carboxyl groups, hydroxyl groups or sulfonic acid groups. Background technique [0002] Nano-hydroxyapatite is an important biomedical new product and new material. Hydroxyapatite is often used as artificial bone in clinical practice, and is used in the synthesis of biomedical materials, defluoridation agent for drinking water, friction agent for high-quality toothpaste, new Smart and sensitive materials. In addition, hydroxyapatite is used as a metal ion carrier to make antibacterial agents, which can be widely used in the fields of medicine, plastics, textiles, coatings and ceramics. [0003] Generally, hydroxyapatite bone implant materials are difficult to be applied to the bearing parts of the human body due to their low strength, especially the high brit...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 殷恒波王爱丽刘冬任敏胡童杰徐艺青姜廷顺吴占敖
Owner JIANGSU UNIV
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