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Hydroxy phosphorite of near infrared fluorescence quantum point mark and its preparation process and application

A technology of fluorescent quantum dots and hydroxyapatite, which is applied in the interdisciplinary field of materials and biomedicine, can solve problems such as discomfort and poor optical stability, achieve stable optical properties, high fluorescence quantum yield, and broad scientific research value Effect

Inactive Publication Date: 2005-11-09
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor optical stability of near-infrared fluorescent organic dye molecules, it is not suitable for long-term excitation to generate heat. If it is used for hyperthermia of bone cancer, it has certain limitations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Synthesize nano-scale hydroxyapatite in aqueous solution first: accurately weigh Ca(NO 3 ) 2 4H 2 O 7.8877g was dissolved with 30mL of deionized water, and its pH was adjusted to 10.5 with ammonia water. Accurate weighing (NH 4 ) 2 HPO 4 2. 6412g was dissolved in 50mL of deionized water, and its pH was adjusted to 10.5 with ammonia water. (NH 4 ) 2 HPO 4 The solution was added dropwise to Ca(NO 3 ) 2 4H 2 O solution and stirred with magnetic force. Drip finished (NH 4 ) 2 HPO 4Afterwards, stirring was continued at 70° C. for 3 h to obtain a milky white sol. After natural cooling, the sol was precipitated by centrifugation, and the precipitate was washed 3 times with deionized water. X-ray diffraction (XRD) analysis shows that the obtained product is hexagonal hydroxyapatite, and transmission electron microscope (TEM) observation results show that the obtained product is needle-shaped nanoparticles with a length between 50 and 240 nm. .

[0028] Synthes...

Embodiment 2

[0032] Take the hydroxyapatite and CdTe solutions prepared in Example 1, dilute and concentrate them respectively, and then mix them. In the diluted mixed system, the concentration of hydroxyapatite is 5 μg / mL, and the concentration of CdTe is 1 ng / mL . In the concentrated mixed system, the concentration of hydroxyapatite is 0.25 g / mL, and the concentration of near-infrared fluorescent quantum dots is 15 mg / mL. After shaking for 30 minutes, after centrifugation, the precipitate was observed by TEM, and the results showed that nanoparticles were adsorbed on the hydroxyapatite, and in the concentrated adsorption product, the hydroxyapatite had been seriously aggregated.

Embodiment 3

[0034] Prepare the nano-hydroxyapatite sol with a concentration of 500 μg / mL according to Example 1, and then spray-dry it under the following conditions:

[0035] (1) The inlet air temperature is 150°C, the outlet air temperature is 95-105, the feed rate is 3mL / min, and the rotation speed of the atomizing disc is 20000r / min.

[0036] (2) The inlet air temperature is 250°C, the outlet air temperature is 100-110°C, the feed rate is 200mL / min, and the rotation speed of the atomizing disc is 20000r / min.

[0037] (3) The inlet air temperature is 30°C, the outlet air temperature is 25-30°C, the feed rate is 0.1mL / min, and the rotation speed of the atomizing disc is 20000r / min.

[0038] TEM observation results show that the obtained dry powder is spherical and round cake-shaped particles of 3-20 μm, and there are a large number of fine pores in the particles.

[0039] Under the condition of nitrogen protection and room temperature, the spray-dried hydroxyapatite powder was respecti...

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Abstract

A hydroxy apatite marked by the nanoparticles of near-infrared fluorescent quantum point for researching the growth of bone and diagnosing and treating the diseases, such as coronary sclerosis, bone cancer, etc is prepared by linking the nanoparticles of near-infrared fluorescent quantum point with the hydroxy opatite via adsorption, ion exchange, or covalent bonding.

Description

technical field [0001] The present invention relates to a method of combining nano-fluorescent labeling materials on hydroxyapatite and its application in biomedicine, especially to connecting near-infrared fluorescent quantum dot nanoparticles to hydroxyapatite to form a marker The composite particle of hydroxyapatite of near-infrared fluorescent quantum dot belongs to the intersection field of materials and biomedicine. Background technique [0002] Hydroxyapatite is a calcium salt of weakly alkaline phosphoric acid. It is the main inorganic component of human and animal bones and teeth. Its chemical formula is Ga 10 (PO 4 ) 6 (OH) 2 . The hydroxyapatite crystal is hexagonal oblique prism, and the size of the small plate-shaped hydroxyapatite in the bone is about (1.5-3.5nm)×(5.0-10.0nm)×(40.0nm-50.0nm), which is a natural nanometer structure. [0003] Studies have found that synthetic hydroxyapatite has excellent biocompatibility and chemical stability, and is an id...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/00
Inventor 储茂泉金鑫
Owner TONGJI UNIV
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