Hybridized fiber contg. high molecular material, carbon material and hydroxy apatite and its prepn. method

A technology of hydroxyapatite and polymer materials, which is applied in fiber processing, fiber chemical characteristics, filament/wire forming, etc., can solve the problem of not having a porous structure and can not meet the biological high performance requirements of porous scaffold composite materials, etc. problem, to achieve the effect of good mechanical properties

Inactive Publication Date: 2006-09-13
BEIJING UNIV OF CHEM TECH
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Problems solved by technology

Chinese patent 02117632.9 discloses a "carbon nanotube-reinforced plastic/ceramic-based bone repair material", which is composed of a certain content of carbon nanotubes, degradable polyhydroxy fatty acid ester and apatite ceramic powder by conventional solid-state extrusion The resulting composite material, due to the introduction of carbon nanotubes, improves the strength of the composite material, but the di

Method used

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  • Hybridized fiber contg. high molecular material, carbon material and hydroxy apatite and its prepn. method
  • Hybridized fiber contg. high molecular material, carbon material and hydroxy apatite and its prepn. method
  • Hybridized fiber contg. high molecular material, carbon material and hydroxy apatite and its prepn. method

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Embodiment 1

[0019] Embodiment 1: Preparation of carbon fiber / nanometer hydroxyapatite nanocomposite particles: Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 Dissolve in deionized water respectively to make a solution with a certain molar concentration, adjust the pH value to 12 and 9 with ammonia water, and the stoichiometric ratio of the reaction is Ca / P=1.67, which is consistent with the Ca / P in the natural bone of the human body; Quality is equivalent to the carbon nanotube (diameter is 20-40nm, produced by Shenzhen Nanometer Harbor Co., Ltd.) and Ca(NO 3 ) 2 4H 2 O solution was mixed, and ultrasonic pre-vibration was started for 10 minutes; the solution was put into the reactor and stirred, and ultrasonic oscillation was used as an auxiliary means, the temperature was about 25°C, and then (NH 4 ) 2 HPO 4 Liquid, drop rate 4.5ml / min, and maintain a pH value of about 10; from (NH 4 ) 2 HPO 4 After the addition of liquid drops is completed, the reaction mixture is taken out within 2...

Embodiment 2

[0020] Embodiment 2: Preparation of carbon fiber / hydroxyapatite nanocomposite particles: Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 Dissolve in deionized water respectively to form a solution with a certain molar concentration, adjust the pH value to 12 and 9 respectively with ammonia water, the stoichiometric ratio of the reaction is Ca / P=1.67, which is consistent with the Ca / P in the natural bone of the human body; Add carbon nanofibers with a mass equivalent to 5% of the mass fraction of calcium ions to Ca(NO 3 ) 2 4H 2 In the O solution, the temperature is 45°C, and the ultrasonic wave is pre-oscillated for 10 minutes; then the Ca(NO 3 ) 2 The solution was added dropwise (NH 4 ) 2 HPO 4 solution, the rate of addition is about 2.5ml / min, during the reaction, keep the pH value of the solution above 10, from (NH 4 ) 2 HPO 4 After the dropwise addition was completed, it was washed and dried at 120°C to obtain the in-situ-synthesized solution and continued to react fo...

Embodiment 3

[0021] Example 3: 50 parts of carbon fiber / hydroxyapatite nanocomposite particles prepared in Example 1 were dispersed in 1,4-dioxane solvent under ultrasonic vibration, and 50 parts of polylactic acid-caprolactone copolymer / Dichloromethane solution is slowly added dropwise to the nano-carbon fiber / nano-hydroxyapatite / acetone dispersion system, and after the addition is completed, continue to ultrasonically oscillate for 0.5h to obtain PLA-CL / nano-carbon material / nano-hydroxyl with a concentration of 6%. Apatite electrospinning suspension, the mixed solution is prepared under the condition of static voltage of 22kV and receiving distance of 9cm to prepare PLA-CL / carbon fiber / hydroxyapatite hybrid fiber with a diameter of 1.5μm-2.0μm .

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Abstract

The invention relates to a macromolecule material/ carbon material/ hydroxyapatite hybridization fiber and the manufacture method. It includes the following steps: compounding carbon material/ hydroxyapatite nm particle, making electric spinning suspension liquid, adopting electric spinning technology to make macromolecule material/ carbon material/ hydroxyapatite hybridization fiber and the carbon material and hydroxyapatite existing as nm compounding particle. The hybridization fiber has 3D multi-hole, and the porosity could be 30-99%, and the fiber diameter could be 20nm-2um. The invention has the excellent mechanical properties and good biocompatibility.

Description

technical field [0001] The invention belongs to a biocomposite material and a preparation method thereof, in particular to a degradable polymer material / hydroxyapatite hybrid fiber reinforced by a nano-carbon material and a preparation method thereof. The hybrid fiber of the invention is suitable for bone Scaffold materials for tissue engineering. Background technique [0002] For a long time, metals and organic polymers have been widely used as bone repair materials in the medical field. However, because the composition is different from natural bone, it is not satisfactory in terms of biocompatibility, human adaptability and mechanical compatibility with natural bone. Clinically, inorganic materials such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) are also used as bone tissue repair materials. Although they have good biological activity and osteocyte induction, their mechanical properties are poor. It often exhibits greater brittleness, poor load bearing ca...

Claims

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Application Information

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IPC IPC(8): D01F6/92D01F9/00D01D5/00
Inventor 杨小平陈国强隋刚邓旭亮宫华俊魏强赵敏利赵秀平
Owner BEIJING UNIV OF CHEM TECH
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