Porous bone prosthesis containing hydroxy apatite component and its preparation method

A technology of hydroxyapatite and bone prosthetics, applied in prosthetics, medical science, etc., can solve the problems of granular ceramics displacement, difficult processing, and high brittleness of block ceramics

Inactive Publication Date: 2003-12-10
SICHUAN UNIV
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  • Abstract
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Problems solved by technology

Because it has a similar composition to the inorganic matter of human hard tissues (such as bones and teeth), it has good biocompatibility and bioactivity, but its block ceramics are brittle, difficult to process, and easy to break; particles Ceramics have the disadvantages of migration and displacement, and the mechanical properties of these calcium phosphate bioactive materials are not satisfactory. The flexural strength and fracture toughness indexes are lower than those of human compact bone, while the elastic modulus is much higher than that of natural bone. bone, thus limiting its clinical application

Method used

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  • Porous bone prosthesis containing hydroxy apatite component and its preparation method
  • Porous bone prosthesis containing hydroxy apatite component and its preparation method
  • Porous bone prosthesis containing hydroxy apatite component and its preparation method

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Embodiment Construction

[0033] (1) Composite material powder:

[0034] Preparation of nano-hydroxyapatite: Feed calcium nitrate and ammonium phosphate at a calcium / phosphorus molar ratio of 1.60 to 1.67, and obtain hydroxyapatite through the following reactions:

[0035] (pH=10~12) the obtained amorphous hydroxyapatite slurry was heated at 70°C for 4 hours to obtain a nano-hydroxyapatite slurry, observed by scanning electron microscope, the particles of hydroxyapatite were within the range of 100nm, It is nano-scale hydroxyapatite, the results of scanning electron microscope observation are as follows: figure 1 shown. The nano-hydroxyapatite slurry is dried at 120° C., ground, and passed through a 200-mesh sieve to obtain nano-hydroxyapatite powder, which is ready for use.

[0036] Polyamide component fine powder: commercially available commercial polyamide 66 or other corresponding polyamide fine powder can be used, or it can be prepared according to the existing reported method.

[0037] P...

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PUM

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Abstract

The porous bnoe prosthesis with good biological compatibility and biological activity is formed from nano hydroxyapatite and polyamide component with weight ratio of 1/1-0.3, and has mutual through pores whose pore size is 1-300 micrometers, and its total porosity is 30-70%. Its preparation method includes the following steps: according to the described ratio mixing fine hydroxyapatite powder and polyamide fine powder, then mixing them with ethyl alcohol solution containing calcium chloride to make solidifiation, and using water to dissolve the above-mentioned obtained material to remove water solubility component from solidified material and form porous structure in the bone prosthesis material.

Description

technical field [0001] The invention relates to a porous bone prosthesis containing hydroxyapatite components, in particular to a composite material porous bone prosthesis in the form of nanometer or non-nanometer hydroxyapatite / polyamide components and a preparation method thereof. Background technique [0002] Bone repair is a new interdisciplinary field of material science and life science. It provides a promising new method for repairing bone defects, bone tumors, and refractory fractures. Porous restorations are the key technology of bone repair engineering. one. The purpose of a porous prosthesis is to provide a three-dimensional scaffold for the cells that build the tissue, providing a suitable environment for cell growth. Porous materials are the basic framework and metabolic site for cell attachment, provide scaffolds for new tissues, and maintain them for a certain period of time until the new tissues have their own biomechanical properties. Porous materials not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44
Inventor 李玉宝魏杰左奕
Owner SICHUAN UNIV
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