Biodegradable multiple targeting hydrogel orientated to eolon as well as its preparation and application
A technology of colon positioning and hydrogel, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of low bioavailability, poor drug stability, and short biological half-life, and achieve good biocompatibility, Cheap and easy to obtain, the effect of mild reaction conditions
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[0031] Embodiment: 1, the synthesis of multiple colon targeting KGM hydrogels
[0032] Reaction solution A: Weigh 1.62 grams of KGM, dissolve it in 200 milliliters of water at 45°C, and place it for a sufficient time to disperse it evenly, pass in argon to drive away the air, dissolve 1.461 grams of ammonium cerium nitrate in dilute nitric acid and add, stir 10 minutes.
[0033] Reaction solution B: Dissolve 0.045 g of surfactant OP-10 in an appropriate amount of water, add 0.147 g of 4,4'-bis(methacrylamido)azobenzene and 40 ml of acrylic acid into the aqueous surfactant solution, and stir Make it dissolve evenly in 30 minutes, and the total volume is 100 milliliters.
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