Biodegradable multiple targeting hydrogel orientated to eolon as well as its preparation and application

A technology of colon positioning and hydrogel, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of low bioavailability, poor drug stability, and short biological half-life, and achieve good biocompatibility, Cheap and easy to obtain, the effect of mild reaction conditions

Inactive Publication Date: 2004-03-10
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Most of these drugs are endogenous substances, which have strong pharmacological effects, few side effects, and rarely cause allergic reactions. However, due to: ① low mucosal permeability at the site of drug administration or drug release, poor drug absorption; ② drug hydrolysis caused by body fluids or enzymatic hydrolysis, so that the stability of the drug is poor; ③The first-pass effect of the liver makes this kind of drug have a short biological half-life and low bioavailability, so the current common route of administration is injection

Method used

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  • Biodegradable multiple targeting hydrogel orientated to eolon as well as its preparation and application
  • Biodegradable multiple targeting hydrogel orientated to eolon as well as its preparation and application
  • Biodegradable multiple targeting hydrogel orientated to eolon as well as its preparation and application

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Experimental program
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Embodiment

[0031] Embodiment: 1, the synthesis of multiple colon targeting KGM hydrogels

[0032] Reaction solution A: Weigh 1.62 grams of KGM, dissolve it in 200 milliliters of water at 45°C, and place it for a sufficient time to disperse it evenly, pass in argon to drive away the air, dissolve 1.461 grams of ammonium cerium nitrate in dilute nitric acid and add, stir 10 minutes.

[0033] Reaction solution B: Dissolve 0.045 g of surfactant OP-10 in an appropriate amount of water, add 0.147 g of 4,4'-bis(methacrylamido)azobenzene and 40 ml of acrylic acid into the aqueous surfactant solution, and stir Make it dissolve evenly in 30 minutes, and the total volume is 100 milliliters.

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Abstract

A biodegradable hydrogel with multiple target location function in colon is prepared from the aqueous solution of konjak glucomannan and acrylic through graft copolymerizing under the action of redox trigger and azo compound as cross-linking agent. It can be used as the carrier of protein polypeptide medicine for locating in the colon and releasing the medicine.

Description

technical field [0001] The invention relates to a biodegradable multi-targeting colon-localized hydrogel, its preparation method and application. Background technique [0002] In recent years, with the development of biotechnology, the research on protein and peptide drugs has attracted more and more attention. Peptide and protein biomacromolecular drugs developed by biotechnology are constantly emerging, and are considered to be the mainstream direction of medicine in the 21st century. Most of these drugs are endogenous substances, which have strong pharmacological effects, few side effects, and rarely cause allergic reactions. However, due to: ① low mucosal permeability at the site of administration or drug release, poor drug absorption; ② drug hydrolysis caused by body fluids Or enzymatic hydrolysis, so that the stability of the drug is poor; ③The first-pass effect of the liver makes this kind of drug have a short biological half-life and low bioavailability, so the curr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36C08F251/00
Inventor 刘芝兰卓仁禧胡菡
Owner WUHAN UNIV
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