ph and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as preparation method and application thereof
A nanoparticle, sensitive technology, applied in the fields of polymer chemistry and biomedical engineering, can solve the problems of fast clearance rate, poor targeting, poor controlled release effect, etc., to achieve improved enrichment and retention, low toxicity, and biocompatibility good sex effect
Active Publication Date: 2014-12-24
天津渤化讯创科技有限公司
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Abstract
The invention relates to a pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle as well as a preparation method and an application thereof. A hydrophilic layer which at least contains PCB (Polycarboxylate Betaine) or PEG (Polyethylene Glycol) is positioned on the surface of the nanoparticle, a hydrophobic nuclei which at least contains a pH-sensitive polymer unit is positioned in the nanoparticle, and an S-S (Disulfide Bond) cross-linking layer which is formed through cross-linking reaction between PDS (Polymethacrylamide Ehtylpyridine Disulfide) units is positioned between the hydrophilic layer and the hydrophobic nuclei. A tumor targeted group can be modified on the hydrophilic layer positioned on the surface of the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, and the gathering of the nanoparticle on a tumor tissue and the endocytosis of the nanoparticle on the tumor cell are accelerated through the specific targeted effect of the nanoparticle on a tumor cell. The pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle disclosed by the invention has the advantages of good biocompatibility and low toxicity. According to the pH and oxidation-reduction dual-sensitive layer cross-linking nanoparticle, a cross-linked structure is dissociated under the action of glutathione inside the tumor cell, so that the release of a medicine is promoted. The preparation method disclosed by the invention is simple, convenient, good in stability and conveniently operated and popularized.
Application Domain
Macromolecular non-active ingredientsAntineoplastic agents +2
Technology Topic
MethacrylamideTumor target +13
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PUM
Property | Measurement | Unit |
Particle size | 142.0 ~ 153.0 | nm |
Particle size | 160.0 ~ 354.0 | nm |
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