Method of preparing controlled-release antibacterial film and implant material by using antibacterial composition

A technology of antibacterial composition and implant material, applied in textiles and papermaking, medical science, prosthesis, etc., can solve problems such as weak binding force, difficult release control, and limited clinical application, and achieve easy lamination and controllable release , high binding effect

Active Publication Date: 2014-03-05
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For broad-spectrum antibiotics, they are generally water-soluble small molecules, which have a weak binding force with hydrophobic pol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1:

[0036] In this example, a sustained-release antibacterial film was prepared according to the following method:

[0037] (1) Preparation of antibacterial composition: add 0.5 mL of levofloxacin aqueous solution (concentration of 50%) to 8 mL of a mixed solvent of DMF and acetone (the volume ratio of DMF / acetone is 1 / 1), and add polylactic acid-glycolic acid copolymer to it. (PLGA, Mw=80,000, LA / GA=75 / 25) 10g and polylactic acid-polyethylene glycol block copolymer (PELA, Mw=20,000, LA / EG=1 / 1) 2g, ultrasound 10 Disperse uniformly after -20 minutes, and stir for 12 hours at 50°C.

[0038] (2) Preparation of slow-release antibacterial film: Inject the mixed solution (antibacterial composition) into a 5mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 25KV, a solution flow rate of 2mL / h, and a receiving distance of 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum drying the coated...

Example Embodiment

[0040] Example 2:

[0041] In this example, a sustained-release antibacterial film was prepared according to the following method:

[0042] (1) Preparation of antibacterial composition: ultrasonically disperse 1g vancomycin in 10mL hexafluoroisopropanol (HFIP) solution, and add polycaprolactone-glycolic acid copolymer (PGCL, Mw=200,000, CL / GA=75 / 25) 3g and gelatin (Mw=80,000) 0.6g, stirred at 70°C for 2 hours.

[0043] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 10mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 25KV, a solution flow rate of 2mL / h, and a receiving distance of 15cm; Spinning for 2 hours to coat the implant material that needs to be coated. Finally, the coated material is vacuum dried at room temperature for 24 hours to remove residual solvents and stored in a 4°C dry box.

[0044] The sustained-release antibacterial film prepared according to this emb...

Example Embodiment

[0045] Example 3:

[0046] In this example, a sustained-release antibacterial film was prepared according to the following method:

[0047] (1) Preparation of antibacterial composition: add 1 mL of metronidazole aqueous solution (concentration of 30%) to 10 mL of a mixed solvent of DMF and acetone (the volume ratio of DMF / acetone is 5 / 1), and add polylactic acid (Mw= 100,000) 10g and polyethylene oxide (Mw=50,000) 2g, sonicated for 10-20 minutes to make it uniformly dispersed, and stirred at 50°C for 12 hours.

[0048] (2) Preparation of sustained-release antibacterial film: Inject the mixed solution (antibacterial composition) into a 5mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 10KV, a solution flow rate of 5mL / h, and a receiving distance of 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum drying the coated implant material at room temperature for 24 hours to remove the residual solvent, ...

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PUM

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Abstract

The invention discloses a method of preparing a controlled-release antibacterial film and an implant material by using an antibacterial composition. The method comprises the following steps of: injecting the antibacterial composition into an injector and installing a stainless steel needle head; coating a to-be-coated implant material by adopting a high-voltage power supply with voltage of 10 KV-30 KV at liquor flow velocity of 1 mL/h-5 mL/h and receiving distance of 5 cm-25 cm; finally, drying the coated implant material in vacuum under the room temperature for 24 hours-48 hours to obtain the controlled-release antibacterial film coated on the implant material, wherein the antibacterial composition comprises: first-class macromolecules selected from polylactic acid, polycaprolactone, polylactic acid-hydroxyacetic acid copolymer and polycaprolactone-hydroxyacetic acid copolymer, second-class macromolecules selected from polylactic acid-polyethylene glycol segmented copolymer, polycaprolactone-polyethylene glycol segmented copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antibacterial agent. The controlled-release antibacterial film prepared by the method disclosed by the invention can realize controlled release of the antibacterial agent.

Description

technical field [0001] The invention relates to the technical field of antibacterial implant materials, in particular to a method for preparing slow-release antibacterial films and implant materials using an antibacterial composition. Background technique [0002] Surgical infection refers to infectious diseases that require surgical treatment and infections that occur after trauma or surgery. It is the most common in the field of surgery, accounting for about 1 / 3 to 1 / 2 of all surgical diseases. Surgical infection is often divided into specific and non-specific infection, the composition of the pathogenic bacteria is complex, once it occurs, treatment is difficult. Surgical infection is generally caused by pathogenic microorganisms invading the human body, but the resistance of the human body is closely related to the occurrence of infection. Common pyogenic pathogens causing surgical infections include Staphylococcus, Streptococcus, Escherichia coli, Pseudomonas aeruginos...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/54A61L31/10A61L31/16D04H1/4382D04H1/728
Inventor 韩志超许杉杉
Owner TRANSEASY MEDICAL TECH
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