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Method of preparing controlled-release antibacterial film and implant material by using antibacterial composition

A technology of antibacterial composition and implant material, applied in textiles and papermaking, medical science, prosthesis, etc., can solve problems such as weak binding force, difficult release control, and limited clinical application, and achieve easy lamination and controllable release , high binding effect

Active Publication Date: 2014-03-05
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For broad-spectrum antibiotics, they are generally water-soluble small molecules, which have a weak binding force with hydrophobic polymers, are difficult to increase the embedding amount, and are difficult to control release, which greatly limits clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The present embodiment prepares slow-release antibacterial film according to the following method:

[0037] (1) Preparation of antibacterial composition: Add 0.5mL levofloxacin aqueous solution (50% concentration) into 8mL DMF and acetone mixed solvent (DMF / acetone volume ratio is 1 / 1), add polylactic acid-glycolic acid copolymerization (PLGA, Mw=80,000, LA / GA=75 / 25) 10g and polylactic acid-polyethylene glycol block copolymer (PELA, Mw=20,000, LA / EG=1 / 1) 2g, ultrasound 10 After -20 minutes, it was uniformly dispersed, and stirred at 50° C. for 12 hours.

[0038] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 5mL syringe, add a No. 5 stainless steel needle, and use a high-voltage power supply with a voltage of 25KV. The flow rate of the solution is 2mL / h, and the receiving distance is 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum-dried the coated implant materia...

Embodiment 2

[0041] The present embodiment prepares slow-release antibacterial film according to the following method:

[0042] (1) Preparation of antibacterial composition: ultrasonically disperse 1 g of vancomycin in 10 mL of hexafluoroisopropanol (HFIP) solution, and add polycaprolactone-glycolic acid copolymer (PGCL, Mw=200,000, CL / GA=75 / 25) 3g and gelatin (Mw=80,000) 0.6g, stirred at 70°C for 2 hours.

[0043] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 10mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 25KV, the solution flow rate is 2mL / h, and the receiving distance is 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum-dried the coated material at room temperature for 24 hours to remove residual solvent, and stored it in a drying oven at 4°C.

[0044] The slow-release antibacterial film prepared according to this embodiment is...

Embodiment 3

[0046] The present embodiment prepares slow-release antibacterial film according to the following method:

[0047] (1) Preparation of antibacterial composition: Add 1mL metronidazole aqueous solution (30% concentration) into 10mL DMF and acetone mixed solvent (DMF / acetone volume ratio is 5 / 1), add polylactic acid (Mw= 100,000) 10g and polyethylene oxide (Mw=50,000) 2g, ultrasonically dispersed for 10-20 minutes, stirred at 50°C for 12 hours.

[0048] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 5mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 10KV, the solution flow rate is 5mL / h, and the receiving distance is 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum-dried the coated implant material at room temperature for 24 hours to remove residual solvent, and stored it in a drying oven at 4°C.

[0049] The slow-release anti...

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PUM

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Abstract

The invention discloses a method of preparing a controlled-release antibacterial film and an implant material by using an antibacterial composition. The method comprises the following steps of: injecting the antibacterial composition into an injector and installing a stainless steel needle head; coating a to-be-coated implant material by adopting a high-voltage power supply with voltage of 10 KV-30 KV at liquor flow velocity of 1 mL / h-5 mL / h and receiving distance of 5 cm-25 cm; finally, drying the coated implant material in vacuum under the room temperature for 24 hours-48 hours to obtain the controlled-release antibacterial film coated on the implant material, wherein the antibacterial composition comprises: first-class macromolecules selected from polylactic acid, polycaprolactone, polylactic acid-hydroxyacetic acid copolymer and polycaprolactone-hydroxyacetic acid copolymer, second-class macromolecules selected from polylactic acid-polyethylene glycol segmented copolymer, polycaprolactone-polyethylene glycol segmented copolymer, polyethylene oxide, polyvinyl alcohol, gelatin and hyaluronic acid, and an antibacterial agent. The controlled-release antibacterial film prepared by the method disclosed by the invention can realize controlled release of the antibacterial agent.

Description

technical field [0001] The invention relates to the technical field of antibacterial implant materials, in particular to a method for preparing slow-release antibacterial films and implant materials using an antibacterial composition. Background technique [0002] Surgical infection refers to infectious diseases that require surgical treatment and infections that occur after trauma or surgery. It is the most common in the field of surgery, accounting for about 1 / 3 to 1 / 2 of all surgical diseases. Surgical infection is often divided into specific and non-specific infection, the composition of the pathogenic bacteria is complex, once it occurs, treatment is difficult. Surgical infection is generally caused by pathogenic microorganisms invading the human body, but the resistance of the human body is closely related to the occurrence of infection. Common pyogenic pathogens causing surgical infections include Staphylococcus, Streptococcus, Escherichia coli, Pseudomonas aeruginos...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/54A61L31/10A61L31/16D04H1/4382D04H1/728
Inventor 韩志超许杉杉
Owner TRANSEASY MEDICAL TECH
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