Method of preparing controlled-release antibacterial film and implant material by using antibacterial composition
A technology of antibacterial composition and implant material, applied in textiles and papermaking, medical science, prosthesis, etc., can solve problems such as weak binding force, difficult release control, and limited clinical application, and achieve easy lamination and controllable release , high binding effect
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Embodiment 1
[0036] The present embodiment prepares slow-release antibacterial film according to the following method:
[0037] (1) Preparation of antibacterial composition: Add 0.5mL levofloxacin aqueous solution (50% concentration) into 8mL DMF and acetone mixed solvent (DMF / acetone volume ratio is 1 / 1), add polylactic acid-glycolic acid copolymerization (PLGA, Mw=80,000, LA / GA=75 / 25) 10g and polylactic acid-polyethylene glycol block copolymer (PELA, Mw=20,000, LA / EG=1 / 1) 2g, ultrasound 10 After -20 minutes, it was uniformly dispersed, and stirred at 50° C. for 12 hours.
[0038] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 5mL syringe, add a No. 5 stainless steel needle, and use a high-voltage power supply with a voltage of 25KV. The flow rate of the solution is 2mL / h, and the receiving distance is 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum-dried the coated implant materia...
Embodiment 2
[0041] The present embodiment prepares slow-release antibacterial film according to the following method:
[0042] (1) Preparation of antibacterial composition: ultrasonically disperse 1 g of vancomycin in 10 mL of hexafluoroisopropanol (HFIP) solution, and add polycaprolactone-glycolic acid copolymer (PGCL, Mw=200,000, CL / GA=75 / 25) 3g and gelatin (Mw=80,000) 0.6g, stirred at 70°C for 2 hours.
[0043] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 10mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 25KV, the solution flow rate is 2mL / h, and the receiving distance is 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum-dried the coated material at room temperature for 24 hours to remove residual solvent, and stored it in a drying oven at 4°C.
[0044] The slow-release antibacterial film prepared according to this embodiment is...
Embodiment 3
[0046] The present embodiment prepares slow-release antibacterial film according to the following method:
[0047] (1) Preparation of antibacterial composition: Add 1mL metronidazole aqueous solution (30% concentration) into 10mL DMF and acetone mixed solvent (DMF / acetone volume ratio is 5 / 1), add polylactic acid (Mw= 100,000) 10g and polyethylene oxide (Mw=50,000) 2g, ultrasonically dispersed for 10-20 minutes, stirred at 50°C for 12 hours.
[0048] (2) Preparation of slow-release antibacterial film: inject the mixed solution (antibacterial composition) into a 5mL syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 10KV, the solution flow rate is 5mL / h, and the receiving distance is 15cm; spinning for 2 hours, coating the implant material to be coated, and finally vacuum-dried the coated implant material at room temperature for 24 hours to remove residual solvent, and stored it in a drying oven at 4°C.
[0049] The slow-release anti...
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