Prussian blue-based intelligent pH-triggered MRI drug release-monitoring synergetic nanometer diagnosis and treatment agent and preparation method thereof

A Prussian blue and nanotechnology, applied in the field of biomedical materials and nanomaterials, to achieve excellent light-to-heat conversion performance
CN105031671AActive Publication Date: 2015-11-11SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Publication Date
2015-11-11

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Abstract

The invention relates to a Prussian blue-based intelligent pH-triggered MRI drug release-monitoring synergetic nanometer diagnosis and treatment agent and a preparation method thereof. The nanometer diagnosis and treatment agent comprises hollow Prussian blue nanometer particles with mesopores. The surfaces of the hollow Prussian blue nanometer particles with mesopores are coated with KxMny[Fe(CN)6]z, wherein x is greater than or equal to 0.05 and less than or equal to 0.3, y is greater than or equal to 0.5 and less than or equal to 0.98 and z is equal to 1. The nanometer diagnosis and treatment agent comprises hollow mesoporous nanometer particles with core-shell structures. The HMPB-Mn nanometer diagnosis and treatment agent is used for tumor part pH-sensitive MRI and pH-sensitive drug release control in chemotherapy. Through combination with thermotherapy, MRI-guided thermotherapy-chemotherapy combined treatment on tumors is realized.
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Description

technical field

[0001] The invention relates to the technical field of nanomaterials and the field of biomedical materials, in particular to a nano-diagnostic and therapeutic agent based on hollow mesoporous Prussian blue pH-responsive nuclear magnetic resonance imaging (MRI) and photoacoustic imaging under the guidance of dual modes of hyperthermia and chemotherapy for synergistic treatment of tumors and its preparation method. Background technique

[0002] Magnetic resonance imaging is a non-invasive imaging method with high resolution and the ability to obtain anatomical and physiological information. It is widely used in the field of diagnosis and treatment. Currently in clinical practice, T 1 weighted contrast ratio T 2 Weighted contrast agents have more advantages, such as it is difficult to distinguish some dark spots due to T 2 The effect of the contrast agent is still caused by blood calcification, metal deposition, or some other background signals. Currently us...

Claims

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