Thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane and preparation method thereof

A technology of isopropyl acrylamide and electrospun fibers is applied in spinning solution preparation, fiber treatment, pharmaceutical formulations, etc., and can solve the problems of polyurethane drug-loaded electrospun fiber membranes that do not have temperature sensitivity and poor mechanical properties, etc. Achieve the effect of easy operation, high drug loading, and reduced diffusion rate

Active Publication Date: 2012-10-17
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems that the existing poly N-isopropylacrylamide drug-loaded electrospun fiber membranes have poor mechanical properties and polyurethane drug-loaded electrospun fiber membranes do not have temperature sensitivity, and provide a temperature-sensitive polymer N-isopropylacrylamide / polyurethane drug-loaded electrospun fiber membrane and preparation method thereof

Method used

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  • Thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane and preparation method thereof
  • Thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane and preparation method thereof
  • Thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane and preparation method thereof

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specific Embodiment approach 1

[0010] Embodiment 1: This embodiment is a temperature-sensitive poly N-isopropylacrylamide / polyurethane drug-loaded electrospun fiber membrane made of polyN-isopropylacrylamide, polyurethane, N,N-dimethylformaldehyde It is prepared from amide and medicine; the mass ratio of the poly-N-isopropylacrylamide to the polyurethane is (1~5):1; the total mass of the poly-N-isopropylacrylamide and the polyurethane to N , the mass ratio of N-dimethylformamide is (10 ~ 15): 100; the mass ratio of the mass of the drug to the total mass of polyN-isopropylacrylamide and polyurethane is (5 ~ 50): 100, The medicine mentioned therein is the medicine which can be dissolved in N,N-dimethylformamide.

[0011] The temperature-sensitive poly-N-isopropylacrylamide / polyurethane drug-loaded electrospun fiber membrane described in this embodiment reduces the drug diffusion rate, prolongs the release time, and can maintain the effect of the drug without frequent administration. At the same time, the phe...

specific Embodiment approach 2

[0015] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the drug is nifedipine, paclitaxel or daunorubicin. Others are the same as the first embodiment.

specific Embodiment approach 3

[0016] Specific embodiment three: This embodiment is a method for preparing a temperature-sensitive poly-N-isopropylacrylamide / polyurethane drug-loaded electrospun fiber membrane, which is specifically completed according to the following steps:

[0017]1. Configure the electrospinning solution: ① Dissolve poly-N-isopropylacrylamide in N,N-dimethylformamide, dissolve and mix completely to obtain poly-N-isopropylacrylamide with a mass fraction of 10%~14%. Propylacrylamide / N,N-dimethylformamide solution; ②Dissolve polyurethane in N,N-dimethylformamide, completely dissolve and mix to obtain polyurethane / N , N-dimethylformamide solution; ③ Under the condition of magnetic stirring at a stirring speed of 60r / min~300r / min, the mass fraction of 10%~14% polyN-isopropylacrylamide / N,N- The dimethylformamide solution and the polyurethane / N,N-dimethylformamide solution with a mass fraction of 10%~15% are mixed together, and continue to be stirred under the condition of magnetic stirring at...

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Abstract

The invention relates to a thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane and a preparation method thereof, relating to a medicine-loading electro-spun fibrous membrane and a preparation method thereof and aiming to solve problems of poor mechanical property of existing poly N-isopropylacrylamide medicine-loading electro-spun fibrous membrane and no temperature sensitivity of a polyurethane medicine-loading electro-spun fibrous membrane. The thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane is prepared by poly N-isopropylacrylamide, polyurethane, N,N-dimethylformamide and a medicine; the preparation method comprises the following steps: 1, preparing static spinning solution; 2, dissolving the medicine so as to obtain the static spinning solution containing the medicine; 3, carrying out electrospinning; and 4, carrying out dry treatment to obtain the thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane. According to the invention, the preparation method is mainly used for preparing the thermo-sensitive poly N-isopropylacrylamide/polyurethane medicine-loading electro-spun fibrous membrane.

Description

technical field [0001] The invention relates to a drug-loaded electrospun fiber membrane and a preparation method thereof. Background technique [0002] In medical treatment, after each administration, there will be a "peak" phenomenon when the drug enters the blood. This kind of administration treatment has obvious disadvantages. Controlled drug release is to use controlled release materials as drug carriers, which reduces the drug diffusion rate and prolongs the release time. It does not require frequent administration and can maintain the effect of the drug. At the same time, it avoids the occurrence of drug "burst release" and reduces Drug side effects. [0003] The polymer nanofiber prepared by electrospinning is a good drug-loading material. On the one hand, according to the consensus of the pathology community, the smaller the size of the drug and the capsule encapsulating the drug, the easier the drug is absorbed by the body, and the larger the surface area of ​​th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728D01D1/02D01D5/00A61K9/70A61K47/34A61K45/00A61K31/4422A61K31/337A61K31/704
Inventor 唐冬雁林秀玲郭玉娣蒋恩英
Owner HARBIN INST OF TECH
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