Preparation method of slow-release solid microspheres with anti-wrinkle effect

Abstract

The invention relates to a preparation method of slow-release solid microspheres with an anti-wrinkle effect. The preparation method is characterized by comprising the steps as follows: A, vitamin A and isododecane are mixed and dissolved; B, vitamin A is adsorbed with polymethyl methacrylate; C, polymethyl methacrylate powder with vitamin A adsorbed is dried and crushed; D, tert-butylhydroquinone, a mixed solution of diethylhexyl syringylidene malonate and octanoic / capric triglyceride, a mixed solution of glyceryl behenate and polyglycerol-6 octastearate, behenyl alcohol, hydrogenated polyisobutene and polydimethylsiloxane are weighed in mass ratio and mixed, and an oil-wax mixed solution is prepared; E, solid particles, the oil-wax mixed solution, deionized water and an ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosslinked polymer are mixed, and an aqueous solution containing solid microspheres is prepared; F, washing and sieving are performed, and the slow-release solid microspheres with the anti-wrinkle effect are obtained. The solid microspheres have the slow vitamin A release and anti-wrinkle effects.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, in particular to a preparation method of slow-release solid microspheres with anti-wrinkle effect. Background technique [0002] Skin aging is a continuous and gradual physiological process that directly affects the appearance and function of the skin. Wrinkles are a significant sign of skin aging. With the improvement of people's living standards, the demand for self-image, anti-aging, wrinkle removal, and youthful rejuvenation is increasing day by day. The development and progress of biochemical technology has uncovered the mechanism of wrinkles and developed corresponding active ingredients, making anti-wrinkle needs possible. At the same time, the safety and efficacy of anti-wrinkle products have naturally become the focus of attention. [0003] The meaning of vitamin A (Vitamin A) refers to a class of substances with vitamin A biological activity, including vitamin A 1 , also known as re...

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Problems solved by technology

[0004] While vitamin A has remarkable efficacy, there are two major problems that limit its wide application: one is its poor stability. The existence of five conjugated double bonds and hydroxyl or ester groups in vitamin A makes its chemical properties active. Oxidation, dehydration, and polymerization reactions are prone to occur under the action of heat and other factors, resulting in changes in its structure, resulting in a decrease in its retention rate and bioavailability; second, it is highly irritating, and peeling, redness, and tingling may occur in the early stage of use The phenomenon, the severity varies from person to person, it is particularly important to control the release rate of vitamin A

[0005] At present, the method to solve the problem of vitamin A stability and irritation is to prepare vitamin A into microcapsules and nano liposomes. Vitamin A microencapsulation has the disadvantages of solvent residue, complicated operation, and high brittleness of the microcapsule membrane; vitamin A nano Liposomes have problems such as high production costs, low embedding efficiency, and poor long-term stability

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