Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Andrographolide dry suspension prepared by fusion spraying and preparation method thereof

A technology of andrographolide and dry suspension, which is applied in the direction of medical preparations containing active ingredients, antiviral agents, and pharmaceutical formulas, and can solve the problems of andrographolide having a bitter taste, being difficult to dissolve in water, and unfavorable for patients to take medicine. , to achieve the effects of good taste, no bitterness, and convenient consumption

Active Publication Date: 2016-05-18
JIANGZI QINGFENG PHARMACEUTICALS INC
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, andrographolide has developed common dosage forms such as tablets, capsules, and dripping pills. However, diterpenoid lactone compounds are difficult to dissolve in water and can only be administered orally
In addition, due to the extremely bitter taste of andrographolide, it is unfavorable for children, the elderly and patients with dysphagia to take medicine. These dosage forms have not solved this problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Andrographolide dry suspension prepared by fusion spraying and preparation method thereof
  • Andrographolide dry suspension prepared by fusion spraying and preparation method thereof
  • Andrographolide dry suspension prepared by fusion spraying and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 15g each of cetyl alcohol and stearyl alcohol in a beaker, heat the beaker in a water bath at 85°C, and when it melts, add 10g andrographolide and stir for 30 minutes with a magnetic stirrer to make the andrographolide mixed After being suspended in stearyl alcohol, hot melt spraying is performed.

[0043] The melting spray parameters are: inlet air temperature 130°C, atomization pressure 0.3Kpa, feeding speed 80ml / min.

[0044] The hot melt spray product is collected, and the andrographolide flavoring mixture is obtained. Mix the mixture with fillers, flavors, sweeteners, sour agents, and suspending agents in appropriate proportions to obtain andrographolide dry suspension.

[0045] The prescription of andrographolide dry suspension is as follows:

[0046] Mixture of andrographolide, cetyl alcohol and stearyl alcohol: 4g

[0047] Lactose: 15.3g

[0048] Xanthan gum: 0.1g

[0049] Micronized silica gel: 0.05g

[0050] Neotame: 0.2g

[0051] Sweet orange flavor: 0.2g

[0052] Ci...

Embodiment 2

[0056] Take 15g each of glyceryl monostearate and glyceryl behenate in a beaker, seal with plastic wrap, heat the beaker in a water bath at 85°C, and when it melts, add 10g andrographolide and use a magnetic stirrer After stirring for 30 minutes, the andrographolide was suspended in stearyl alcohol and then sprayed with hot melt.

[0057] The prescription of andrographolide dry suspension is as follows:

[0058] Mixture of andrographolide, glyceryl monostearate and glyceryl behenate: 4g

[0059] Starch: 15.3g

[0060] Xanthan gum: 0.1g

[0061] Micronized silica gel: 0.05g

[0062] Neotame: 0.2g

[0063] Sweet orange flavor: 0.2g

[0064] Citric acid: 0.2g

[0065] The melting spray parameters are: inlet air temperature 130°C, atomization pressure 0.3Kpa, feeding speed 80ml / min.

[0066] The hot melt spray product is collected, and the andrographolide flavoring mixture is obtained. . Mix the mixture with fillers, flavors, sweeteners, sour agents, and suspending agents in appropriate propo...

Embodiment 3

[0070] Take 10g each of stearyl alcohol and glyceryl monostearate in a beaker, seal with plastic wrap, heat the beaker in a water bath at 85°C, wait for it to melt, add 10g andrographolide, and stir with a magnetic stirrer for 30 After the andrographolide is suspended in stearyl alcohol, hot melt spraying is performed.

[0071] The melting spray parameters are: the inlet air temperature is 130°C, the atomization pressure is 0.3Kpa, and the feed rate is 50ml / min.

[0072] The hot melt spray product is collected, and the andrographolide flavoring mixture is obtained. Mix the mixture with fillers, flavors, sweeteners, sour agents, and suspending agents in appropriate proportions to obtain andrographolide dry suspension.

[0073] The prescription of andrographolide dry suspension is as follows:

[0074] Mixture of andrographolide and glyceryl monostearate: 4g

[0075] Lactose: 15.3g

[0076] Sodium alginate: 0.1g

[0077] Micronized silica gel: 0.05g

[0078] Neotame: 0.2g

[0079] Sweet oran...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses an andrographolide dry suspension which is particles prepared from andrographolide and accessories by mixing and spraying, wherein the accessories have relatively low melting points and are any two of hexadecanol, octadecanol, glyceryl monostearate, glyceryl behenate, stearic acid, beewax, polyvinyl alcohol and polyethylene glycol; the total mass of the accessories with relatively low melting points is 0.1-10 times that of andrographolide; and the accessories also include at least one other accessory. The andrographolide dry suspension disclosed by the invention is convenient to take simply by adding a little water; and with little bitterness, the andrographolide dry suspension realizes a good taste modifying effect on andrographolide and is suitable for children, old people and patients suffering dysphagia.

Description

Technical field: [0001] The invention relates to a dry suspension of andrographolide and a preparation method thereof. Background technique: [0002] Whether it is chemical medicine or traditional Chinese medicine, the bitter taste of the medicine is one of the reasons why it is not accepted by people. Andrographolide is a diterpene lactone compound, which has the effects of dispelling heat, detoxification, anti-inflammatory and analgesic, and is resistant to bacteria and viruses. Upper respiratory tract infections and dysentery have special effects and are known as natural antibiotics. In recent years, andrographolide has developed common dosage forms such as tablets, capsules, and dripping pills. However, diterpene lactone compounds are difficult to dissolve in water and can only be administered orally. In addition, due to the extremely bitter taste of andrographolide, it is not conducive to taking medicine for children, the elderly and patients with dysphagia. None of these d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12
CPCA61K9/1617A61K9/1652A61K31/365
Inventor 罗晓健欧阳婷杨小玲吕武清简辉崔刚刘地发饶小勇张尧刘艳红殷华峰胡晓强田佳明汤新乾
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com