Compound sweet zinc cream used for treating eczema of infant and preparation method thereof

A technology for infant eczema and compound glycine, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as hirsutism, abnormal liver and kidney function, and leukopenia

Inactive Publication Date: 2013-03-27
黄石市第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used therapeutic drugs include zinc oxide oil for external use and compound preparations of corticosteroids (such as Yifeisa cream and Perisone cream). Among them, Yifeiza cream and Perisone cream contain hormone components, and long-term use can cause skin atrophy, dryness, Telangiectasia, hirsutism, and even adverse reactions such as leukopenia and abnormal liver and kidney function will seriously affect the growth and development of children
Oil agents such as zinc oxide oil are inconvenient to apply to hair and exudate parts, and are not easy to clean

Method used

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  • Compound sweet zinc cream used for treating eczema of infant and preparation method thereof
  • Compound sweet zinc cream used for treating eczema of infant and preparation method thereof
  • Compound sweet zinc cream used for treating eczema of infant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] a. Take 220g of polyoxyethylene triricinoleate, 40g of isopropyl myristate, 5.0g of vitamin E, 1.0g of menthol, and 30ml of absolute ethanol, mix and stir for 20-30 minutes to obtain liquid A ( Ie oil phase);

[0028] b. Take 2.0g of zinc oxide and 2.0g of baicalin, add 622ml of purified water preheated to 50-60°C and stir to dissolve it. After 2-3 minutes, it will become orange red, which is liquid B (ie water phase);

[0029] c. Take 8.0g of dipotassium glycyrrhizinate, add 60ml of butanediol and stir to dissolve, then add 10.0g of nicotinamide, stir to dissolve, and prepare liquid C;

[0030] d. Add the above solution B to solution C, stir evenly, control the temperature of the solution at 30-35℃, add the mixture of solution B and solution C to solution A, and stir for 20-30 minutes to obtain translucent orange The emulsion is divided into packages to prepare the compound galzine emulsion for treating infantile eczema of the present invention.

Embodiment 2

[0032] a. Take 200g of polyoxyethylene glycerol triricinoleate, 30g of isopropyl myristate, 2.0g of vitamin E, 1.0g of menthol, and 25ml of absolute ethanol, mix and stir for 20-30 minutes to obtain liquid A;

[0033] b. Take 1.0g of zinc oxide and 1.0g of baicalin, add 683ml of purified water preheated to 50-60°C and stir to dissolve it. After 2-3 minutes, orange-red liquid B is prepared;

[0034] c. Take 2.0 g of dipotassium glycyrrhizinate, add 50 ml of butanediol and stir to dissolve, then add 5 g of nicotinamide, stir to dissolve, and prepare liquid C;

[0035] d. Add liquid B to liquid C, stir evenly, control the temperature at 30-35°C, add it to liquid A and stir for 20-30 minutes to obtain a translucent orange emulsion.

Embodiment 3

[0037] a. Take 240g of polyoxyethylene triricinoleate, 50g of isopropyl myristate, 8.0g of vitamin E, 2.0g of menthol, and 35ml of absolute ethanol, mix and stir for 20-30 minutes to obtain liquid A;

[0038] b. Take 4.0g of zinc oxide and 5.0g of baicalin, add 558ml of purified water preheated to 50-60°C and stir to dissolve it. After 2-3 minutes, it will become orange red, which is liquid B;

[0039] c. Take 13g of dipotassium glycyrrhizinate, add 70ml of butanediol and stir to dissolve, then add 15g of nicotinamide, stir to dissolve, and prepare liquid C;

[0040] d. Add liquid B to liquid C, stir evenly, control the temperature at 30-35°C, add it to liquid A and stir for 20-30 minutes to obtain a translucent orange emulsion.

[0041] The properties of the compound zinc zinc emulsion for treating infantile eczema are translucent orange-yellow to light brown emulsions; it has a fragrance and a refreshing feeling.

[0042] Functions and indications: antibacterial, anti-inflammatory, a...

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Abstract

The invention relates to an externally applied medicine and in particular to compound sweet zinc cream used for treating eczema of an infant and a preparation method thereof. The compound sweet zinc cream provided by the invention mainly comprises dipotassium glycyrrhizinate, baicalin, zinc oxide, nicotinamide, menthol, vitamin E, glycerin three castor acid polyoxyethylene ester 35 and isopropyl myristate; the preparation method of the compound sweet zinc cream comprises the following steps: respectively taking glycerin three castor acid polyoxyethylene ester 35, isopropyl myristate, vitamin E and menthol to prepare solution A; taking zinc oxide and baicalin, adding a right amount of water at the temperature of 50-60 DEG C to prepare solution B, taking dipotassium glycyrrhizinate and nicotinamide to prepare solution C, adding solution B into solution C, stirring to be uniform, then adding mixed solution into the solution A, stirring for 20-30 minutes, so as to obtain semi-transparent orange emulsion, and split charging, so that the compound sweet zinc cream is obtained. Clinical curative effect observation shows that the effective rate of the compound sweet zinc cream prepared by adopting the preparation method provided by the invention for treating the eczema of the infant can reach up to 91%, and the compound sweet zinc cream can be directly applied to skins and hairs and is good in dispersibility, easy to clean and convenient to use.

Description

Technical field [0001] The invention relates to a medicine for external use, in particular to a compound zinc zinc emulsion for treating infantile eczema and a preparation method thereof. Background technique [0002] Infant eczema, also known as atopic dermatitis (AD), is a common skin disease in infants and young children. It is more common in infants and young children under 0-2 years old. It is more common on the head and face, buttocks and flexed limbs. It is generally believed that it has a certain relationship with overnutrition, indigestion, food allergy or certain external stimulating factors, Staphylococcus aureus and Candida infections, and genetics. In mild cases, local skin erythema, papules, and blisters are accompanied by itching. In severe cases, epidermal erosions, secretions, and severe itching often occur, which affect the normal health and development of babies. At present, the commonly used treatment drugs include topical zinc oxide oil and corticosteroid co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61K9/107A61K33/30A61K47/34A61P17/00A61K31/7048A61K31/704A61K31/455A61K31/045A61K31/355
Inventor 刘新庭於席芳张松黄朝卫丁东珅刘挺何美云
Owner 黄石市第一医院
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