The invention discloses a preparation method of anti-alcoholism healthcare beverage capable of rapidly replenishing water, and the method comprises the following steps of: mixing and crushing the root of kudzu vine and Turnjujube to decoct twice, mixing decocted filtrates, then, respectively adding melatonin, sodium citrate, potassium chloride, cysteine, taurine, Maltose oligosaccharide, fructo-oligose, vitamin and oleuropein in turn, and dissolving, homogenizing, filling and sterilizing the mixture, thereby obtaining the anti-alcoholism healthcare beverage. According to the invention, after drinking the beverage, a body is in a normal physiological balanced state by keeping the balance of cell electrolyte and potential balance of cell membranes, so that the normal metabolic mechanism of the body is recovered; some pharmaceutical materials are added to strengthen body endurance, relieve fatigue, restrain stimulation of alcohol on the nerve centre, protect grain functions and promote sleep; and the effects of protecting livers, detoxifying, refreshing and hairdressing are finally achieved.