Transdermally absorbed preparation of anti-dementia drug

一种制剂、痴呆的技术，应用在药物组合、非有效成分的医用配制品、含有效成分的医用配制品等方向，能够解决药物透过性低、吸收困难等问题，达到抑制皮肤刺激的效果

Inactive Publication Date: 2012-10-24
后藤武
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in general, the drug permeability of the skin is low, so it is considered difficult to absorb the amount that can exert a sufficient effect from the skin into the body.

Method used

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  • Transdermally absorbed preparation of anti-dementia drug
  • Transdermally absorbed preparation of anti-dementia drug
  • Transdermally absorbed preparation of anti-dementia drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Preparation of drug-containing layer

[0085] Prepare Donepezil, Eudragit according to the ratio of the following prescription (注册商标) E 100, triethyl citrate, IPM (isopropyl myristate) and SML (sorbitan monolaurate), they are mixed and stirred in an appropriate amount of toluene. Add SIS (styrene-isoprene-styrene block copolymer, Kraton (注册商标) D1111K, manufactured by Kraton Corporation), ALCON P-100 (manufactured by Arakawa Chemical Industry Co., Ltd.), and a paste solution was obtained.

[0086] [Table 1]

[0087]

[0088]The above paste solution was coated on a polyethylene terephthalate liner, and dried at 80° C. for 15 minutes to obtain a drug-containing layer. Adjusted so that the amount of the dried drug-containing layer is 50 g / m 2 .

[0089] Then, the upper support (Scotchpak (商标) 9732, manufactured by 3M), to obtain a transdermal preparation.

Embodiment 2

[0091] A percutaneous absorption preparation was prepared in the same manner as in Example 1 except that the formulation was changed as described below.

[0092] [Table 2]

[0093]

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PUM

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Abstract

Disclosed is a transdermally absorbed preparation wherein an anti-dementia drug can be administered transdermally in an efficient manner and with low skin irritation. More specifically, the transdermally absorbed preparation contains the anti-dementia therapeutic drug, a macromolecular compound having an amino group, a polyvalent carboxylate ester, a fatty acid alkylester, a styrenic macromolecular compound, and a tackifying resin.

Description

[0001] References to related applications [0002] This patent application claims priority based on Japanese Patent Application No. 2009-285450 filed on December 16, 2009, and the entire disclosure content of said prior patent application is incorporated as a part of the disclosure of this specification. technical field [0003] The present invention relates to a percutaneous absorption preparation of an anti-dementia drug with less skin irritation. Background technique [0004] In recent years, with the increase of elderly people, the number of patients with dementia such as Alzheimer's disease has also increased, and the care of patients has become a social issue. On the other hand, the development of anti-dementia drugs is also rapidly progressing. For example, donepezil hydrochloride is widely used as a therapeutic agent for Alzheimer's disease having an acetylcholinesterase inhibitory effect. In the past, these anti-dementia drugs were mostly administered orally in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/13A61K31/27A61K31/445A61K31/473A61K31/55A61K45/00A61K47/06A61K47/14A61K47/32A61K47/46A61P25/28
CPCA61K47/32A61K47/14A61K9/7061A61K47/26A61K31/445A61K31/27A61K31/13A61K31/473A61K9/7053A61K31/55A61K9/7076A61P25/28A61K9/70
Inventor 伊东健
Owner 后藤武
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