Preparation absorbed through skin

A preparation and adhesive technology, which is applied in the field of percutaneous absorption preparations, can solve problems such as skin irritation, and achieve the effect of less skin irritation

Inactive Publication Date: 2002-05-22
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] On the other hand, many compounds have been reported to cause skin irritation when transdermally absorbed

Method used

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  • Preparation absorbed through skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102]An acrylic adhesive (75 parts, (2-ethylhexyl) acrylate / acrylic acid copolymer, (2-ethylhexyl) acrylate / acrylic acid=95 / 5 (weight ratio)) was dissolved in ethyl acetate. Diethyl sebacate (20 parts) and free-form ethylpyridine (5 parts) were added thereto to obtain an adhesive layer-forming coating solution. This coating solution was applied onto a release-treated polyester film to a thickness of 30 µm after drying, and dried (formation of an adhesive layer B). Separately, the above coating solution was coated on a carrier non-woven fabric (polyester film with a thickness of 6 μm and a basis weight of 8 g / m 2 on a laminate of polyester nonwoven fabric) to a thickness of 60 μm after drying, and dried (to form an adhesive layer A).

[0103] As the release controlling layer, a 50 m thick high molecular weight porous polyethylene film (porosity: 45%, polyethylene film produced by NITTO DENKO CORPORATION, trademark BREATHRON) was used. Adhesive layer B on the polyester film o...

Embodiment 2

[0105] A polyisobutylene binder (60 parts, a mixture of polyisobutylene having a viscosity average molecular weight of 1,400,000 (100 parts) and polyisobutylene having a viscosity average molecular weight of 60,000 (100 parts)) was dissolved in hexane. Isopropyl myristate (30 parts) and free-form ethylpyridine (10 parts) were added to obtain a coating solution for forming an adhesive layer. This coating solution was applied onto a release-treated polyester film to a thickness of 20 µm after drying, and dried (formation of an adhesive layer B). Separately, the above coating solution was coated on a carrier non-woven fabric (polyester film with a thickness of 6 μm and a basis weight of 8 g / m 2 on a laminate of polyester nonwoven fabric) to a thickness of 30 micrometers after drying, and dried (to form an adhesive layer A).

[0106] As the release controlling layer, a 50 µm thick ultrahigh molecular weight porous polyethylene film (porosity: 30%, ultrahigh molecular weight polye...

Embodiment 1

[0112] The percutaneous absorption preparations obtained in the above-mentioned examples and comparative examples were punched into 10 cm 2 Rounds, and subjected to underwater release tests according to Japanese Pharmacopoeia, Diffusion Test Method 2 (Pump Method). The results are shown in figure 1 . figure 1 The results clearly show that the presence of the release controlling layer in the adhesive layer can give the desired controlled pattern of drug release. Test Example 2 (skin irritation test)

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Abstract

A percutaneously absorptive preparation is provided, which preparation having a support and an adhesive layer having a release-controlling layer, which is formed at least on one side of the support, wherein the adhesive layer contains an adhesive and 0.5 - 60 wt% of a drug except 1,2-ethanediol derivatives.

Description

technical field [0001] The present invention relates to a percutaneous absorption preparation, which contains a specific amount of drugs other than 1,2-ethylene glycol derivatives, the preparation can make the drug continuously percutaneously absorbed into the body, and the preparation can inhibit the absorption of drugs by the drug. Caused by skin irritation. Background technique [0002] For drug administration, preparations in the form of drug adhesive tablets, so-called percutaneous absorption preparations, have attracted attention in recent years due to their feasible administration methods and easy control of administration. The mixture acts as a paste to the skin. [0003] However, the function of the skin is originally as a barrier system to protect the body from the external environment, and can effectively prevent the invasion of external substances to the body. In order to fully exert the pharmacological effects of transdermally absorbed drugs, it is necessary t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70
CPCA61K9/7061
Inventor 堀光彦松冈贤介味吞宪二郎仲野善久
Owner NITTO DENKO CORP
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