35 results about "Ethanediols" patented technology

The invention relates to the technical field of bioengineering and fine chemical engineering, in particular to epoxide hydrolase, a gene, a carrier, engineering bacteria and application, and the amino acid sequence of the epoxide hydrolase is shown as SEQ ID NO.3. The epoxide hydrolase disclosed by the invention has the advantages that the epoxide hydrolase is Sphingopyis macrogoltabia EY-1, and the structural formula of the epoxide hydrolase is as shown in the specification. According to the invention, a recombinant plasmid pET-28a-smh containing an optimized gene and a genetic engineering bacterium E.coli / smh are constructed, the engineering bacterium is induced to over-express the recombinant epoxide hydrolase SmEH, and the recombinant epoxide hydrolase SmEH has catalytic activity. According to the present invention, the E.coli / smh whole cell is adopted to respectively catalyze the hydrolysis reaction of the (R)-styrene oxide (SO) and the (S)-styrene oxide (SO) so as to obtain the (R)-styrene oxide (SO) and the (S)-1, 2-phenyl glycol (1-Phenyl-1, 2-ethanediol, PED) with high optical purity, and the application of the E.coli / smh whole cell to respectively catalyze the hydrolysis reaction of the (R)-styrene oxide (SO) and the (S)-1, 2-phenyl glycol (1-Phenyl-1, 2-ethanediol, PED) is provided;

A filter material is shown comprising a cellulose fiber-based substrate, an additive and an adhesion promoter, wherein the mass ratio of the additive and the adhesion promoter is at least 1:3 and at most 2:1, and the additive and the adhesion promoter together constitute at least 3% and at most 40% of the mass of the cellulose fiber-based substrate, wherein the additive is triethyl citrate, triacetin or a mixture of these substances, and wherein the adhesion promoter is selected from the group consisting of ethanediol, propanediol, butanediol, pentanediol and glycerin diacetate or mixtures thereof.

The invention discloses a nano compound with solubilizing and absorption promoting effects and a preparation method thereof, and belongs to the technical field of flavone oral absorption. The nano-composite prepared by the invention comprises vitamin E polyethylene glycol succinate serving as a first component, an alpha-hydrogen-omega-hydroxyl (oxy-1, 2-ethanediyl) polymer serving as a second component, grease serving as a third component and a solubilizer serving as a fourth component. The prepared nano-composite can enhance the encapsulation efficiency and stability of insoluble flavone compounds, can promote the uptake of flavonoid active substances, prolongs the action time of the active substances in vivo, and improves the bioavailability of the active substances; the nano-carrier is used as a carrier to convey the absorption enhancer and the insoluble active substance, so that the oral absorption rate of the active substance is effectively improved; the preparation method is simple in process condition, can be directly taken orally, is convenient to use, is high in bioavailability, can give full play to the advantages of flavone compounds, and has important application value in the technical field of flavone oral absorption.

A non-linear PEGylated lipid of the Formula (1) contains a tertiary amine; wherein, B1 and B2 are linking bonds or alkylene groups; L1, L2, Ld, and Lx are linking bonds or divalent linking groups; R1 and R2 are C1-50 aliphatic hydrocarbon groups or C1-50 residues of aliphatic hydrocarbon derivatives, each containing 0-10 heteroatoms; y is 2 or 3; X is C or CH; XPEG is a polyethylene glycol component. Compared with linear PEGylated lipids, the PEGylated lipid can realize better surface modification of LNP, better protective effects, extended systemic circulation of LNP, and significantly reduced biological toxicity of LNP. The LNP pharmaceutical composition shows excellent drug delivery capabilities. The lipid-nucleic acid pharmaceutical composition and its formulation exhibit higher pharmaceutical efficacy, especially the LNP-nucleic acid pharmaceutical composition.

The invention provides an anti-neuroinflammation medicine as well as a preparation method and application thereof. The anti-neuroinflammation medicine comprises an active component and lipidosome, the active component is an inhibitor 4-aminobenzoyl hydrazine of myeloperoxidase; the liposome is prepared from phospholipid, cholesterol and distearoyl phosphatidyl ethanolamine-thioketal-polyethylene glycol; the method comprises the following steps: weighing lipidosome and 4-aminobenzoyl hydrazine, dissolving, and carrying out rotary evaporation to obtain a lipid membrane; adding a phosphate buffer solution into the lipid membrane, stirring in a water bath, performing ultrasonic treatment, filtering, centrifuging and purifying to obtain the medicine, according to the active oxygen response-based liposome delivery system disclosed by the invention, 4-aminobenzoyl hydrazine is encapsulated in liposome to form a drug, and after the drug enters a brain inflammation microenvironment area of the Alzheimer's disease, the active oxygen can break a thioketal bond, so that local release of 4-aminobenzoyl hydrazine is triggered, targeted inhibition of myeloperoxidase is realized, and the drug delivery effect is improved. The oxidative stress level is reduced, the neuroinflammation is relieved, and the cognitive impairment is effectively improved.

The present invention discloses a non-linear PEGylated lipid, including the structure represented by the Formula (1); wherein, B1 and B2 are linking bonds or alkylene groups; L1 and L2 are linking bonds or divalent linking groups; Lx, Y, and Ld are divalent linking groups; R1 and R2 are C4-50 hydrocarbon groups or C4-50 residues of hydrocarbon derivative containing 1-4 heteroatoms; X is —CH< orn1, n2, and n3 are integers in the range of 4-250; T is a terminal group. Compared with linear PEGylated lipids, the non-linear PEGylated lipid provided herein can realize better protective effects toward the modified LNPs. The lipid pharmaceutical composition of the present invention exhibits high efficiency of drug encapsulation, appropriate particle size, non-toxicity, and good stability in serum. The LNP-nucleic acid pharmaceutical composition of the present invention demonstrates an excellent ability to complex with nucleic acids and shows high transfection activity.

To provide an aqueous inkjet ink which, even when printed on a low-absorbency printing substrate, can produce printed matter free from beading and pinholes and excellent in migration resistance, and also has good intermittent ejection performance.SOLUTION: The aqueous inkjet ink contains a pigment, a binder resin, an acetylenediol-based surfactant (A), and glycol monoethers (B1). The acetylenediol-based surfactant (A) contains 2-600 ppm of an unmodified acetylenediol-based surfactant (A1) and an alkylene oxide-modified acetylenediol-based surfactant (A2) having an HLB value of 6-12. The mass ratio of the content of the glycol monoethers (B1) to the content of the alkylene oxide-modified acetylenediol-based surfactant (A2) is 0.5-50.SELECTED DRAWING: None

The invention relates to a process for preparing (hetero)aromatic compounds substituted with a hydroxyethylamino group (B) from aromatic compounds bearing an amino group (A) in the presence i) of (di)(alkyl)glycolaldehyde dimer and ii) in a reduction medium, it being understood that step i) and ii) are performed simultaneously or as a "one pot" reaction.

The invention belongs to the crossing field of traditional Chinese medicine modernization and biotechnology, and particularly relates to application of a metabolic marker in preparation of a product for auxiliary diagnosis of retinal vein occlusion (RVO) or evaluation of prognosis of treatment of RVO by ginseng-wolfberry omentum granules. The metabolic marker is selected from at least one of the following metabolites: leukotriene B4, (R)-2-feruloyl-1-(4-hydroxyphenyl)-1, 2-ethylene glycol, hyoscyamine base A6, 11, 12-epoxyeicosatrienoic acid, 3, 3 ', 4, 4'-tetrahydroxy-5, 6, 7, 8, 9, 10, 11, 12-epoxyeicosatrienoic acid, 3, 3 ', 4, 4'-tetrahydroxyl-5, 6, 7, 8, 10-tetrahydroxyl-5, 7, 8, 10 The invention relates to an anti-inflammatory agent which is prepared from 5, 5 '-diisopropyl-2, 2'-dimethyl biphenyl (3, 3 ', 4, 4', 1-ethyl piperidine, flavin mononucleotide, crystal orchid glycoside, 2-O-caffeoyl arbutin, dimethyl ellagic acid glucuronide, 4 '-hydroxy-3, 4, 5-resveratrol trimethyl ether, 3'-methoxy petamicin, phenylalanyl-leucyl-isoleucyl-tyrosine and dihydroferulic acid-4-sulfate.

The application belongs to the field of organic synthesis, and particularly relates to a method for synergistically synthesizing 1,1-diaryl-2-alkyl compounds by using nickel and light. The method comprises the following steps: using styrene derivatives, p-bromoacetophenone and tert-butyl bromide as raw materials, and mixing a metal nickel catalyst (nickel bis(acetylacetone)), a photocatalyst (1,2,3,5-tetrakis(carbazole-9-yl)-4,6-dicyano benzene), a nitrogen ligand ((4S,4'S)-1,1'-bis(3-tert-butylphenyl)-4,4',5,5'-tetrahydro-4,4'-bis[(1S)-1-methylpropyl]-2,2'-bis-4H-imidazole), a Bronsted base (N,N-dicyclohexylmethylamine), a reducing agent (1,4-dihydropyridine derivatives) and an organic solvent (glycol dimethyl ether, isopropyl ether) to generate a three-component cross-coupling reaction and synthesize 1,1-diaryl-2-alkyl compounds with one chiral center. The three-component cross-coupling reaction is realized by using nickel and light, so that the use of a metal reducing agent is avoided, and the preparation raw materials are not needed. The method has the advantages of high reaction yield, high enantiomeric selectivity, fast reaction speed, easy-to-obtain raw materials and simple process.

The invention relates to a process for preparing (hetero)aromatic compounds substituted with a hydroxyethylamino group (B) from aromatic compounds bearing a nitro(so) group (A) in the presence i) of (di)(alkyl)glycolaldehyde dimer and ii) in a reduction medium, it being understood that step i) and ii) are performed simultaneously or as a "one pot" reaction.

A glycosylation method involving a trivalent iodine reagent, wherein a glycosyl donor (I) is activated in the presence of a trivalent iodine reagent and a transition metal catalyst, and then reacts with a acceptor (II) under acid catalysis or directly to obtain a glycosylation product (III); in the glycosyl donor (I), Gly is a glycosyl group in which one or more hydroxyl groups on the sugar ring are protected by a protecting group; X is an oxygen, sulfur, or selenium atom; R is an alkyl group or an aryl group; the acceptor (II) is a nucleophile selected from sugars, alcohols, phenols, flavonoids, carboxylic acids, phosphates, pyrimidines, purines, amides, sulfonamides, guanidines, arylamines, indoles, enol silyl ethers, thiols, or thiophenol containing one or more free hydroxyl groups.

This invention provides an anti-fogging, antibacterial, and antistatic coating, its preparation method, and its application. The anti-fogging, antibacterial, and antistatic coating comprises a substrate layer, an antistatic primer layer, and an anti-fogging and antibacterial coating. The substrate layer is thermoplastic polyurethane, polyethylene terephthalate, or cellulose triacetate. The antistatic primer layer comprises a dual-curing prepolymer, a reactive diluent, a first photoinitiator, a thermal initiator, an antistatic agent, and a first solvent. The anti-fogging and antibacterial coating comprises an allyl alkyl imidazole bromide prepolymer, modified inorganic particles, a hydrophilic UV prepolymer, a second photoinitiator, and a second solvent. It is obtained by preparing an antistatic coating liquid, an anti-fogging and antibacterial coating liquid, an antistatic primer layer, and an anti-fogging, antibacterial, and antistatic coating. The anti-fogging, antibacterial, and antistatic coating prepared by this invention can be used in the preparation of mirror protective layers and has good anti-fogging, antibacterial, and antistatic properties.

The invention discloses a soldering flux for welding a lead-acid storage battery, which is characterized by comprising the following components in percentage by weight: 20-25% of a deoxidant, 10-20% of an activator, 2-5% of a surfactant, 1-2% of a corrosion inhibitor, 2-3% of an additive and the balance of a solvent, the deoxidant is any one of phosphoric acid, phosphorous acid and metaphosphoric acid; the activating agent is any one of oxalic acid, succinic acid, glutaric acid, citric acid, malic acid and tartaric acid; the surfactant is any one of polyoxyethylene ether, sodium dodecyl benzene sulfonate, alkyl betaine and perfluoroalkyl sulfonate; the corrosion inhibitor is any one of triethanolamine, octadecylamine, hexadecyl trimethyl ammonium bromide, benzimidazole and benzotriazole; the additive is ethyl acetate and s-triazine in a ratio of 4: 3; the solvent is any one of ethylene glycol, propylene glycol ether, propylene glycol, glycerol and 1, 4-butanediol. The method aims to solve the problem of halogen element residues in the cast welding process of the lead-acid storage battery.

The invention discloses a cobalt plating inhibitor, a cobalt electroplating solution and an electroplating method, and belongs to the technical field of electroplating. The chemical structural formula of the cobalt plating inhibitor is shown in the specification, wherein L1, L2 and L3 are respectively and independently selected from at least one of a single bond, alkylene and polyethylene glycol; r1, R2 and R3 are respectively and independently selected from at least one of hydrogen, hydroxyl, amino, sulfydryl, carboxyl, acyl, alkyl, naphthenic base, unsaturated alkyl, aldehyde group, carboxylic acid group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted aryl ester; at least one of R1, R2 and R3 contains an unsaturated bond. The inhibitor is beneficial to filling of metal cobalt in a nanoscale interconnection groove or through hole without geometric defects, and is also beneficial to reduction of the resistivity of a metal cobalt coating.

Resins for use in toys and methods for making the same are provided. In preferred embodiments, the resins comprise 30% to 55% w / w of Ethoxylated (10) Bisphenol A Diacrylate; 20% to 35% w / w of 1,3-Hexanediol, 2-ethyl-, polymer with 1,6-diisocyanatohexane, 2-hydroxyethyl acrylate- and propylene glycol monoacrylate-blocked; 20% to 30% w / w of Hexanedioic acid, polymer with 1,2-ethanediol and 5-isocyanato-1-(isocyanatometheyl)-1,3,3-trimethylcyclohexane, 2-hydroxyethyl acrylate-blocked; 1.9%±0.5% w / w of 1-Hydroxycyclohexyl phenyl ketone; 0.43%±0.05% w / w of Ethyl trimethylbenzoyl phenylphosphinate; 0.07±0.05% w / w of Diphenyl (2, 4, 6-trimethyl benzoyl) phosphine oxide; and less than 0.19% w / w of 2-hydroxyethyl acrylate.

A compound of formula I or a pharmaceutically acceptable salt, wherein R1 and R2 are independently selected from H, or a C1-C6 alkyl, a 3-8-membered cycloalkyl or a 6-20-membered aryl, and the alkyl, cycloalkyl and aryl can be further substituted with one or more mutually independent substituents; m is an integer greater than 1; and n is an integer greater than or equal to 0. Further disclosed are a method for preparing the above-mentioned compound or the pharmaceutically acceptable salt, and the use of the compound or the pharmaceutically acceptable salt. A new pegylated phosphoric acid prodrug compound molecule is synthesized, and the synthesis route has the characteristics of readily available raw materials, mild reaction conditions, simple operation and low costs, and is suitable for subsequent research and production. The compound and a composition thereof can be used for treating or preventing viral infections in humans or animals. The compound and the composition thereof can be used to effectively inhibit feline infectious peritonitis virus (FIPV) infections and treat feline infectious peritonitis.

Provided are heterobifunctional chemical linkers that are useful in protein degradation agents and other medicinal chemical applications.Heterobifunctional linkers include alkyne-piperidine and alkane-piperidine linkers; alkane-piperazine linkers; alkane amino PEGylation linkers; dipiperazine linkers; piperazine-pyridine / pyrimidine-alkyne linkers; pyridine-PEG-piperazine linkers and pyrimidine-piperazine-PEG linkers.Also provided are combinations of provided linkers with ligands that target degradation pathways, such as E3 ubiquitin ligase enzymes.

The invention belongs to the technical field of bacteriostatic agents, and particularly relates to pyridine ether biquaternary ammonium salt as well as a preparation method and application thereof. The method comprises the following steps: taking 3-fluoropyridine as an initial raw material, reacting with triethylene glycol to obtain 1, 2-bis (2-(pyridine-3-oxy) ethyoxyl) ethane, and carrying out quaternization reaction on the 1, 2-bis (2-(pyridine-3-oxy) ethyoxyl) ethane and brominated alkane to obtain the pyridine ether biquaternary ammonium salt. The pyridine ether biquaternary ammonium salt type bacteriostatic agent has a good bacteriostatic effect on staphylococcus aureus in gram-positive bacteria, when the concentration is 10 g / mL, the bacteriostatic rate of the bacteriostatic agent exceeds that of antibiotic erythromycin with the concentration being 40 g / mL, and the efficient and low-dosage bacteriostatic effect is achieved. The molecular structure of the pyridine ether biquaternary ammonium salt type bacteriostatic agent provided by the invention simultaneously contains three structural units with bacteriostatic activity, namely the ether bond, the pyridine ring and the quaternary ammonium salt, so that a multi-component synergistic bacteriostatic effect can be realized without compounding, and the antibacterial property is remarkably improved.

A protective film forming composition which has good mask (protection) function against a wet etching liquid and a high dry etching rate during processing of a semiconductor substrate and also has good coverage even in a stepped substrate, and from which a flat film can be formed due to a small difference in film thickness after being embedded; a protective film produced using said composition; a substrate with a resist pattern; and a method for manufacturing a semiconductor device. This protective film forming composition against a wet etching liquid for semiconductors contains an organic solvent and a polymer having, at a terminal thereof, a structure containing at least one pair of two adjacent hydroxyl groups in a molecule. The structure containing two adjacent hydroxyl groups in a molecule may be 1,2-ethanediol structure (A).

Polyethylene glycol derivative modified interleukin-12 (IL-12), a preparation method thereof and an application thereof. The polyethylene glycol derivative modified IL-12 is obtained by performing a modification reaction on a polyethylene glycol derivative and IL-12. Active groups of the polyethylene glycol derivative comprise one or more among an aldehyde group, ketone group, maleimide group, vinyl sulfone group, terminal alkyne group, succinimide group, p-nitrophenyl group, isobutyl chloroformate group, halo group, thio group and carboxyl group. Active groups of the IL-12 comprise one or more among an N-terminal α-amino group, ε-amino group of a lysine side chain and free sulfhydryl group of cysteine. IL-12 that has passed through polyethylene glycol derivative modification may balance the drug activity and drug toxicity of IL-12, and a larger dose may be used in a single dose. In addition, the IL-12 may maintain an effective blood concentration in the body for a longer period of time without causing serous toxic side effects, which is beneficial for the continuity of treatment and improves the treatment effects of diseases.

The present invention discloses a novel green ethano-terpene solvent of plant origin formed of a synergistic mixture of terpenes and ethanol. It relates to the method for obtaining this solvent, which is based on the recovery of terpene compounds from plants through low-temperature solid-liquid extraction, using ethanol as a GRAS solvent, the method being characterised in that it comprises the following steps: washing the plants with water; removing the washing water; grinding the plants; bringing the plant material into contact with ethanol; removing the residues; decolourising the extract by vacuum evaporation to obtain a transparent solvent rich in terpenes. The green ethano-terpene solvent is characterised by its purity, selectivity, recyclability, biodegradability, and its wide usage in processes for the extraction and / or solubilisation of plant and / or animal and / or prokaryotic biological materials, in synthesis and formulation in the food, pharmaceutical, cosmetic, chemical, perfume and fuel industries, as well as in cleaning and disinfection processes.

The application discloses a polypeptide kallikrein promoter and application thereof, and belongs to the technical field of cosmetics. The polypeptide kallikrein promoter comprises a polypeptide compound, a preservative and water. The polypeptide compound is at least one of red scorpion toxin, acetyl tetrapeptide-2, acetyl tetrapeptide-3, hexapeptide-11, hyaluronic acid polypeptide, palmitoyl tripeptide-5 and acetyl octapeptide-3. The preservative is a mixture of glycerol, ethylhexyl glycerin and 1,2-ethanediol. The polypeptide kallikrein promoter can not only promote skin desquamation by activating KLKs, but also delay skin aging by inhibiting MMPs gene expression, and can be used for developing products with skin renewal and anti-aging dual effects.

The invention discloses a bacillus subtilis alcohol dehydrogenase mutant with improved specific activity and application thereof, and belongs to the technical field of gene engineering and enzyme engineering. Amino acids at 49th, 266th and 292th sites of (2, 3)-butanediol dehydrogenase (BsBDHA) of bacillus subtilis are subjected to single mutation and combined mutation to obtain a mutant of which the specific activity and the catalytic efficiency for catalyzing (R)-1-phenyl-1, 2-glycol are remarkably improved, the specific activity reaches 2.44 U / mg or above, and the catalytic efficiency reaches 0.96 mM <-1 > s <-1 > or above; compared with BsBDHAI49L / V266L in the prior art, the (2, 3)-butanediol dehydrogenase mutant disclosed by the invention is improved by 23% or more; the catalytic efficiency of the mutant BsBDHAI49L / V266L is improved by 2.46 times or more compared with that of the mutant BsBDHAI49L / V266L in the prior art; and the conversion rate of 2-hydroxyacetophenone in 12 hours reaches 95.3%.

The invention relates to polypropylene molten aerogel high-resilience cloud wool and a preparation method thereof.The polypropylene molten aerogel high-resilience cloud wool is prepared from, by weight, 75-85 parts of polypropylene resin matrix, 8-12 parts of hydrophobic nano SiO2 aerogel powder, 6-10 parts of polyolefin elastomer, 3-5 parts of compatibilizer, 0.5-0.9 part of foaming agent, 0.5-1.0 part of initiator, 0.3-0.6 part of cross-linking agent and 0.2-0.3 part of antioxidant. The surface of the hydrophobic nano SiO2 aerogel powder is modified by a silane coupling agent, and the cross-linking agent comprises 3-mercaptopropionic acid-[2, 4, 6-trioxo-1, 3, 5-triazine-1, 3, 5 (2H, 4H, 6H)-secondary group] tris (2, 1-glycol ester) and triallyl isocyanurate, and the surface of the hydrophobic nano SiO2 aerogel powder is modified by a silane coupling agent, and the cross-linking agent comprises 3-mercaptopropionic acid-[2, 4, 6-trioxo-1, 3, 5-triazine-1, 3, 5 (2H, 4H, 6H)-secondary group] tris (2, 1-glycol ester) and triallyl isocyanurate. According to the preparation method, a cross-linking agent compounded from 3-mercaptopropionic acid-[2, 4, 6-trioxo-1, 3, 5-triazine-1, 3, 5 (2H, 4H, 6H)-secondary] tris-2, 1-glycol ester and triallyl isocyanurate is adopted, and hydrophobic nano SiO2 aerogel powder with the surface modified by a silane coupling agent and a polyolefin elastomer are uniformly dispersed in a polypropylene resin matrix, so that the polypropylene composite material is prepared. And the composite cloud velvet material has high resilience and excellent heat preservation performance at the same time.

The invention provides a quantitative analysis method of ethanethiol, which adopts a gas chromatograph for analysis, and selects a DB-WAXetr strong polarity polyethylene glycol capillary column as a chromatographic column; the column temperature is set as follows: the initial temperature is 80 DEG C and is kept for 5 minutes; raising the temperature to 220 DEG C at the temperature raising rate of 20 DEG C / min, and keeping the temperature for 1 minute; the detection method is suitable for TCD and FID detectors, wherein the TCD can accurately and quantitatively analyze the content of low-boiling-point impurities such as methyl mercaptan, water, H2S, ethane, methane, propane and the like; the FID detector can be used for analyzing high-boiling-point impurities such as ethyl sulfide, isopropyl ethyl sulfide, n-butyl ethyl sulfide, thiophene and xylene contained in a sample; through mutual combination and verification of data of the two detectors, an analysis basis is provided for accurate quantification of the content of each component in a high-purity ethanethiol product.

The invention discloses a filter material comprising a cellulose-fibre-based substrate, an additive and an adhesion promoter, wherein the mass ratio of additive and adhesion promoter is at least 1:3 and at most 2:1 and the additive and the adhesion promoter make up in total at least 3% and at most 40% of the mass of the cellulose-fibre-based substrate, wherein the additive is triethyl citrate, triacetin or a mixture of these substances, and wherein the adhesion promoter is selected from the group consisting of ethanediol, propanediol, butanediol, pentanediol and glycerol diacetate or mixtures thereof.

To provide a release agent composition which is excellent in performance of removing various functional layers and ink films formed on a plastic base material, hardly causes damage such as whitening of the plastic base material due to removal of the functional layers and ink cleaning, and is excellent in performance of removing stains derived from contents in a used polyethylene terephthalate container.SOLUTION: [In the general formula (1), R1 represents an alkyl group having 4 to 18 carbon atoms or an alkenyl group having 4 to 18 carbon atoms, A1O represents an alkyleneoxy group having 2 to 4 carbon atoms, n and m represent an average number of a repeating unit of A1O and are each independently a number of 0 or more, n + m is a number of 1 to 50, and when a plurality of A1O are present, they may be the same as or different from each other.]. (A) an amine-based nonionic surfactant which is a compound represented by the following formula (I): SELECTED DRAWING: None