A Novel Selenic Acid Biomaterial with the Function of Protecting Alcoholic Liver Injury

A technology of alcoholic liver injury and biomaterials, applied in the field of food science, can solve the problems of narrow safe dosage range of selenium, achieve broad development and utilization prospects, high absorption rate, and reduce the degree of cell inflammation

Inactive Publication Date: 2011-12-28
天津市食品加工工程中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Selenium is an essential trace element for humans and animals. It can protect the structure and function of cell membranes, enhance the body's immunity, and play an important role in maintaining biological functions and preventing diseases. However, the safe dosage range of selenium is very narrow, so low-toxic selenium compounds The development and research of the

Method used

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  • A Novel Selenic Acid Biomaterial with the Function of Protecting Alcoholic Liver Injury
  • A Novel Selenic Acid Biomaterial with the Function of Protecting Alcoholic Liver Injury
  • A Novel Selenic Acid Biomaterial with the Function of Protecting Alcoholic Liver Injury

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Experimental program
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Effect test

Embodiment 1

[0018] Embodiment 1: Grouping and administration of experimental animals

[0019] After one week of normal feeding, the mice were randomly divided into 4 groups, 15 in each group, namely the normal group, the alcohol group, the arginine selenate group and the selenium dioxide group. The daily recommended intake of selenium is 100 μg·d -1 ·60kg -1 10 times of the dose is the mouse dose, and the arginine selenate group and the selenium dioxide group are gavaged with this dose for one week, and the normal group and the alcohol group are gavaged with the same amount of distilled water. One week later, the alcohol group, the arginine selenate group, and the selenium dioxide group were intragastrically administered 12 mL·kg of 56° liquor every day. -1 ·Bw, intragastric administration twice a day, at the same time, the arginine selenate group and the selenium dioxide group continued intragastric administration of the same dose of drugs, and the normal group was intragastric adminis...

Embodiment 2

[0020] Embodiment 2: Grouping and administration of experimental animals

[0021] After one week of normal feeding, the mice were randomly divided into 4 groups, 15 in each group, namely the normal group, the alcohol group, the arginine selenate group and the selenium dioxide group. The daily recommended intake of selenium is 100 μg·d -1 ·60kg -1 30 times of the dose is the dose for mice, the arginine selenate group and the selenium dioxide group are gavaged with this dose for one week, and the normal group and the alcohol group are gavaged with the same amount of distilled water. One week later, the alcohol group, the arginine selenate group, and the selenium dioxide group were intragastrically administered 12 mL·kg of 56° liquor every day. -1 ·Bw, intragastric administration twice a day, at the same time, the arginine selenate group and the selenium dioxide group continued intragastric administration of the same dose of drugs, and the normal group was intragastric administ...

Embodiment 3

[0022] Embodiment 3: Grouping and administration of experimental animals

[0023] After one week of normal feeding, the mice were randomly divided into 4 groups, 15 in each group, namely the normal group, the alcohol group, the arginine selenate group and the selenium dioxide group. The daily recommended intake of selenium is 100 μg·d -1 ·60kg -1 40 times of the dose is the dose for mice, the arginine selenate group and the selenium dioxide group were gavaged with this dose for one week, and the normal group and the alcohol group were gavaged with the same amount of distilled water. One week later, the alcohol group, the arginine selenate group, and the selenium dioxide group were intragastrically administered 12 mL·kg of 56° liquor every day. -1 ·Bw, intragastric administration twice a day, at the same time, the arginine selenate group and the selenium dioxide group continued intragastric administration of the same dose of drugs, and the normal group was intragastric admini...

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Abstract

The invention discloses the functionality and action mechanism of a novel selenic acid biomaterial-arginine selenate for protecting alcoholic liver injury. Arginine selenate has a significant inhibitory effect on alcohol-induced hepatocyte morphological changes, steatosis, and liver fibrosis. Compared with selenium dioxide, arginine selenate can more effectively maintain the body's antioxidant capacity, and at the same time effectively reduce Alcohol-induced elevation of serum cholesterol and maintenance of higher levels of HDL. Arginine selenate also effectively reduced the apoptosis rate of alcohol-induced hepatocytes and the increase of tumor necrosis factor. The main mechanism may be that arginine selenate increases the activity of GSH-Px by participating in the synthesis of GSH-Px, and at the same time reduces the consumption of SOD and GSH, and strengthens the overall antioxidant capacity of the body. Thus reducing the free radical attack on cell membranes, proteins and lipids, while inhibiting the stimulation of collagen synthesis and apoptosis by cytokines.

Description

technical field [0001] The invention belongs to the field of food science and technology. In particular, it relates to the function and mechanism of a novel selenic acid biomaterial-arginine selenate in protecting alcoholic liver injury. Background technique [0002] Selenium is an essential trace element for humans and animals. It can protect the structure and function of cell membranes, enhance the body's immunity, and play an important role in maintaining biological functions and preventing diseases. However, the safe dosage range of selenium is very narrow, so low-toxic selenium compounds The development and research of it has attracted extensive attention. More and more evidence shows that organic selenium is obviously superior to inorganic selenium in terms of safety performance and disease prevention, and has the advantages of low toxicity, high absorption rate and good effect. Contents of the invention [0003] The purpose of the present invention is to verify th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C391/00A61K31/21A61P1/16A61P39/06
Inventor 刘安军郑捷王维君曹蓓刘彦平
Owner 天津市食品加工工程中心
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