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Ketoprofen-containing poultice

A technology of cataplasm and ketoprofen, which is applied in the field of cataplasm to achieve the effects of improving skin permeability, inhibiting skin irritation, and excellent pharmacological effects

Inactive Publication Date: 2016-09-21
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when a transdermal preparation containing a nonsteroidal anti-inflammatory analgesic as a photosensitive compound is used as an active ingredient, photosensitivity may slightly appear as a side effect

Method used

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  • Ketoprofen-containing poultice
  • Ketoprofen-containing poultice
  • Ketoprofen-containing poultice

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] After the cataplasm of Example 1 was applied to the back skin of the guinea pig for 4 hours, the cataplasm was peeled off. Cut the skin of the position where the cataplasm was applied, extract the skin slice with methanol, use high-speed liquid chromatography (HPLC), calculate the concentration (μg / cm2) of ketoprofen and BM-DBM in the gained skin slice 2 ). In addition, the same operation was performed for the patch containing 2% by mass of ketoprofen (comparative example 2), and the concentrations of ketoprofen and BM-DBM were calculated.

[0089]

[0090] Table 8 shows the concentrations of ketoprofen and BM-DBM for the cataplasm of Example 1 and the patch of Comparative Example 2. The intradermal concentration of ketoprofen when using the cataplasm of Example 1 was about the same as when using the patch of Comparative Example 2. On the other hand, the intradermal concentration of BM-DBM when using the cataplasm of Example 1 was higher than when using the patch o...

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Abstract

Provided is a poultice provided with a support and an ointment layer on top of the support, wherein the ointment layer contains 1.5-2.5 mass% of ketoprofen, 1.5-2.5 mass% of 4-tert-butyl-4'-methoxydibenzoylmethane, and 12-18 mass% of propylene glycol based on the total mass of the ointment layer.

Description

technical field [0001] The present invention relates to cataplasms containing ketoprofen. Background technique [0002] Non-steroidal anti-inflammatory analgesics such as ketoprofen have excellent anti-inflammatory and analgesic effects, so they have been used as active ingredients in patches, gels, and creams such as dressings or ointments. , ointments, liniments (liniments) and other forms of transdermal preparations. However, when a transdermal preparation containing a nonsteroidal anti-inflammatory analgesic as a photosensitive compound is used as an active ingredient, photosensitivity may slightly appear as a side effect. [0003] Skin irritation such as photosensitivity is a dermatitis symptom accompanied by itchy erythema, rash, and irritation caused by exposure of photosensitive compounds such as ketoprofen to ultraviolet rays. In order to further reduce the chance of side effects, it is advisable to control outdoor activities in a way that does not expose to ultra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/70A61K47/08A61K47/10A61P29/00
CPCA61K9/0014A61K9/7023A61K31/192A61P29/00A61K2121/00A61K9/7069A61K31/12A61K47/10
Inventor 水流诚一郎桢正义山外真嗣寺原孝明
Owner HISAMITSU PHARM CO INC
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