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Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer

a technology for diabetic ulcers and compositions, which is applied in the direction of drug compositions, immunological disorders, metabolism disorders, etc., can solve the problems of no ideal and effective pharmaceuticals for diabetic ulcers world wide, complicated pathogenetic mechanism of diabetic ulcers, and many professionals not very familiar with the difference between wound and ulcers

Inactive Publication Date: 2012-07-05
XU RONGXIANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0029]This present invention also relates to a kind of medicine box, which includes the pharmaceutical compositions described in the present invention or the herein said medical dressing, and Directions for Use. The medicine box integrates with the said pharmaceutical compositions or the said medical dressing containing this said pharmaceutical compositions, meanwhile, at least one copy of Directions for Use is enclosed along with, making it more convenient to use the medicine box of this present invention in clinical practice.
[0040]The pharmaceutical composition of this present invention effectively segregate ulcerous wound surface, and avoid stimuli of external factors to exposed nerve endings, resulting in an analgesic effect. Besides that the pharmaceutical layer blocks the stimuli of foreign objects to wound surface, other mechanisms that involve the said analgesic effect are: (1) beta-sitosterol and other ingredients in the pharmaceutical composition of this present invention can effectively reduce inflammatory reactions; (2) the pharmaceutical itself is non-irritative; (3) the pharmaceutical improves local microcirculation, enhances local blood flow, promotes local metabolism, attenuates stimulatory effect of tissue ischemia, anoxia, edema on nerve endings. (4) in the course, a physiological environment for in situ stem cell differentiation is also established, leading to the activation of the dormant stem cells and regeneration of the tissue, and these are all favorable to ulcer healing.

Problems solved by technology

Although the definition of ulcer seems self-evident, many professionals are not very familiar with the difference between wound and ulcer.
So far, there are still no ideal and effective pharmaceuticals for diabetic ulcer world wide.
The pathogenetic mechanism of diabetic ulcer is very complicated, and there is no unified and common clear understanding for the time being.
These pathological changes result in ischemia of soft tissue in leg and on body surface, and finally evolve into ulcer.
During this pathogenesis, all the neural functions are damaged, but often, the longest and the thinnest nervous fiber, including the motor nerve that controls the foot muscles, is damaged first.
Functional loss of lumbrical muscle leads to foot deformation, and this increases the pressure or friction in the sites of sub-metatarsophalangeal joint, toe dorsum or toe tips and the like.
These factors easily induce ulcers.
Damage to autonomic nerve function also emerges in the earlier stage of neuropathy, causing a series of pathological changes, including arteriovenous shunt, decreased tissue infusion, alopecia, functional loss of sebaceous glands and sweat glands.
These elements work together and result in skin dryness, scale formation and liability to rhagades.
Role of immunopathy in diabetic infection is still in dispute, most of the researchers believe that the inefficient control of blood sugar could make patients more vulnerable to infection.
Long-term angiopathy makes blood vessel sclerotic and stenotic, especially in the lower extremities, and gives a negative effect on blood supply, further leading to skin malnutrition.
Pathological changes of nerves can increase the threshold level of skin pain and pressure sense, and change pressure—bearing sites of planta, therefore, infection often occurs to feet, especially toes.
In this situation, if injuries happen to the skin, the repair is often inefficient, and the skin will be very susceptible to secondary infection, ulcer and gangrene for feet.
Still, diabetic patients with athlete's foot, onychomycosis and long-term use of antibiotics are more vulnerable to foot fungal infection.
For elderly diabetic patients, due to long course of disease, less activities, less efficient peripheral circulation, skin ulcer is more likely to occur.
But once that diabetic ulcer occur, there will be no ideal and effective therapy for curing this ulcerous wound surface, surgical amputation is still often adopted for the time being.

Method used

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  • Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer
  • Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer
  • Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer

Examples

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embodiments

[0066]Next, with the aid of attached pictures, the present invention will be explained further by way of the following non-limited examples. Persons skilled in the art all know and agree that, without departing from the spirit of this present invention, many modifications can be made to the present invention, but, even so, all the said modifications will also fall into the category of this present invention. In addition, all raw material including Huangqin, Huanglian, Huangbai, earthworm and poppy capsule, sesame oil can be easily obtained in the market.

example 1

[0067]In accordance with the method revealed in Example 1 in Chinese Patent ZL931002761, and according to the detailed and the same raw material revealed, sesame oil extract of Huangqin, Huanglian, Huangbai, earthworm and poppy capsule is obtained. By mixing the above-mentioned sesame oil extract and beeswax, Pharmaceutical Composition 1 described in the present invention is obtained.

example 2

[0068]According to the same method described in Chinese Patent ZL931002761, the pharmaceutical composition described in the present invention is manufactured, except that 10 Kg of each of Huanglian, Huangqin and Huangbai pieces, 2 kg of each of earthworm and poppy capsule, 100 Kg of sesame oiland 10 Kg of beeswax are used. By mixing the beeswax and sesame oil extract of Huangqin, Huanglian, Huangbai, earthworm and poppy capsule, Pharmaceutical Composition 2 is obtained.

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Abstract

The use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer in limb or on body surface, or in preparing medical dressing. The pharmaceutical compositions consist of (A) 3 to 15% by weight of edible beeswax and (B) 85 to 97% by weight of sesame oil extract of Scutellaria root, Coptis root, Phellodendron bark, earthworm and poppy capsule, based on the total weight of the pharmaceutical compositions. In the sesame oil extract, each of Scutellaria root, Coptis root, Phellodendron bark, earthworm and poppy capsule is in an amount of 2 to 10% by weight of dry raw material based on the total weight of sesame oil. A medical dressing for treating diabetic ulcer and corresponding medicine box enclosing the said dressing are also provided.

Description

FIELD OF THE INVENTION[0001]This invention relates to use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer in limb or on body surface, or in preparing medical dressing. This invention also relates to a kind of medical dressing for treating diabetic ulcer in limb or on body surface, and the corresponding medicine box enclosing the said dressing.BACKGROUND OF THE INVENTION[0002]Chinese Patent ZL931002761 has disclosed a pharmaceutical composition for treating thermal injuries; the said pharmaceutical composition consists of (A) 3 to 15% of edible beeswax and (B) 85 to 97% of sesame oil extract of Huangqin, Huanglian, Huangbai, earthworm and poppy capsule, based on the total weight of the pharmaceutical composition. In the sesame oil extract, each of Huangqin, Huanglian, Huangbai, earthworm and poppy capsule is in an amount of 2 to 10% by weight of dry raw material based on the total weight of sesame oil.[0003]Furthermore, the pharmaceutical compo...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P17/02
CPCA61F13/00012A61F13/00063A61K35/644A61K35/62A61L15/34A61K36/756A61K36/718A61K36/66A61K36/539A61K36/185A61K9/06A61K9/0014A61F2013/00927A61F2013/0091A61F2013/0054A61F13/00072A61F13/069A61F2013/00161A61K2300/00A61P1/04A61P17/02A61P25/00A61P37/00A61P43/00A61P9/00A61P3/10A61F13/01012A61K36/481A61K36/75A61K47/44A61L15/40A61L15/44A61K36/71
Inventor XU, RONGXIANG
Owner XU RONGXIANG
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