The present application relates to the technical field of
plant extraction, and particularly relates to a process method for jointly preparing
baicalein and
wogonin, comprising the following steps: (1) crushing the roots of
Scutellaria baicalensis Georgi, adding boiling water to extract, and combining the extract; (2) concentrating the extract and adjusting the pH; (3) heating, cooling and adjusting the pH of the concentrated solution to obtain a
lysis solution; (4) introducing the
lysis solution into a resin column, eluting with
purified water and an
organic solvent, and concentrating the collected
desorption solution; (5) adjusting the pH of the concentrated solution, filtering,
drying and crushing the collected first
filter cake to obtain a
baicalein product; (6) adjusting the pH of the first filtrate and concentrating; (7) cooling, filtering and eluting the concentrated solution, and collecting the second filtrate and second
filter cake; (8) adding
purified water to the second
filter cake to make a pulp, filtering,
drying and collecting the third filter cake to obtain a
wogonin product; and (9)
spray drying the second filtrate to obtain a
Scutellaria baicalensis Georgi flavone product. The above process method can simultaneously obtain high-yield
baicalein,
wogonin and
Scutellaria baicalensis Georgi flavone products.