Tablet suitable for rheumatic arthritis and preparation method thereof

Abstract

The invention discloses a tablet suitable for rheumatic arthritis and a preparation method thereof. The tablet is prepared from a formula I and a formula II, wherein the formula I comprises notopterygium root, cassia twig, radix angelicae pubescentis, radix saposhnikoviae, radix aconiti preparata, gentiana macrophylla, ramulus mori, kadsura pepper stem and caulis spatholobi; a formula II: rhizoma anemarrhenae, radix stephaniae tetrandrae, honeysuckle stem, radix scutellariae, fructus gardeniae, cortex phellodendri, rhizoma smilacis glabrae, cortex moutan, radix rehmanniae recen, gypsum, turtle shell and liquorice; a formula III: prepared arisaema consanguineum schott, rhizoma typhonii, roasted stiff silkworm, nidus vespae, peach kernel, safflower, rhizoma drynariae, teasel root, native copper, centipede and zaocys dhumnade; and a formula IV is prepared from angelica sinensis, radix clematidis, rhizoma atractylodis, ligusticum wallichii, radix angelicae, pawpaw, radix gentianae, radix salviae miltiorrhizae, semen coicis and rhizoma atractylodis macrocephalae. According to the traditional Chinese medicine composition, the pharmacological activity of all the components is fully reserved, local red, swollen, hot and painful inflammation expressions of knees, ankles, shoulders, wrists, elbows and hip joints caused by rheumatic inflammation can be controlled, and whole body symptoms and exudative inflammation can be eliminated. The traditional Chinese medicine can comprehensively treat various complications of rheumatic arthritis, can be directly taken orally, and is convenient to use.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly to a tablet applicable to rheumatic arthritis and a preparation method thereof. Background Art

[0002] Rheumatic arthritis is a chronic and recurrent arthritic disease that occurs in the human body due to exposure to wind, cold, and dampness. The main manifestations are joint swelling, pain, and limited flexion and extension.

[0003] Modern medicine believes that rheumatism is a common acute or chronic systemic collagen tissue inflammation that recurs frequently. It is most significantly manifested in the heart and joints. The clinical manifestations are mainly myocarditis and arthritis, accompanied by symptoms such as fever, toxemia, rash, subcutaneous nodules, and chorea. Significant heart damage often remains after an acute attack. The exact cause of rheumatism has not been fully understood so far, but based on the analysis of some data in clinical, epidemiological, and immunological aspects, it is supported that the infection of group A beta-hemolytic streptococcus is related to the onset of rheumatism. At present, it is also noted that the pathological changes are mainly edema of the joint synovium and surrounding tissues, and there is fibrin and granulocyte exudation in the joint capsule fluid. No joint deformity remains after the active stage.

[0004] Traditional Chinese medicine summarized the clinical symptoms similar to this disease under "Li Jie Feng". Zhang Zhongjing of the Han Dynasty proposed in "Synopsis of the Golden Chamber" the pathogenesis such as sweating and entering the water, heat being transformed into damp pathogen, blood deficiency and wind disturbance, and wind and blood congestion. Chao Yuanfang of the Sui Dynasty explained some syndromes of this disease in "Treatise on the Causes and Symptoms of Various Diseases - Li Jie Feng Syndrome": "Wind passes through the joints and combines with qi and blood to attack each other, so there is pain. When qi and blood are deficient, sweating occurs. When wind and cold attack the tendons, flexion and extension are impossible." Chen Yan of the Song Dynasty believed in "Discussion on the Etiology and Treatment of Diseases Caused by the Three Pathogenic Factors - Discussion on Li Jie" that this disease "is caused by the combination of wind, cold, and dampness. When the pain is like a twitch, it is mostly due to cold; when there is yellow sweat in Li Jie, it is mostly due to wind." Zhang Jingyue of the Ming Dynasty advocated that Li Jie Feng is the disease of Bi syndrome with wandering pain, and its clinical feature is that the pain has no fixed location.

[0005] Rheumatic arthritis is an autoimmune disease that occurs in joints after group A beta-hemolytic streptococcus infection. This disease mostly occurs in winter, spring, and rainy seasons, and dampness and cold are important inducing factors. The male-female ratio of patients is quite equal. It often affects children and adolescents during the first onset, and is more common in school-age children aged 7 - 16. During an acute attack, the affected joints show redness, swelling, heat, pain, and limited movement. Typical arthritis also has the following characteristics: ① It is migratory and can migrate from one joint to another within a few hours or days; ② It is often multiple, manifested as more than 2 joints being affected simultaneously; ③ The joint pain is closely related to weather changes, aggravated in damp or cold conditions, and the symptoms can naturally relieve with the change of the environment; ④ It mostly affects large joints such as knees, ankles, elbows, and wrists; ⑤ Salicylic acid preparations have obvious effects, and the symptoms are significantly relieved 24 hours after taking the medicine.

[0006] Based on its clinical characteristics, Traditional Chinese Medicine (TCM) classifies it as "Bi syndrome." Its pathogenesis is largely attributed to the invasion of wind-cold, damp-heat, and other pathogenic factors into the muscles and bones, which then accumulate in the meridians and joints, obstructing the flow of Qi and blood. However, a deficiency of vital energy, weak pores, and insufficient defensive Qi are prerequisites for such invasion. Clinical treatment primarily follows the principles of treating Bi syndrome based on its etiology and pathogenesis, employing methods such as dispelling wind and dampness, relieving cold and pain, clearing heat and promoting diuresis, invigorating blood circulation and unblocking the meridians, and supporting vital energy. Commonly used representative formulas include modified Dang Gui Bu Xue Tang and modified Bu Yang Huan Wu Tang.

[0007] Rheumatism, also known as "bi syndrome" or "bi disease," is a common, frequently occurring, and difficult-to-treat disease. With societal progress and increased health awareness, rheumatism plays an increasingly important role in the spectrum of human diseases. However, even with today's advanced science, these diseases, which seriously threaten human health, remain a crucial research topic. Rheumatoid arthritis and its complications, in particular, drive our research into the updating and efficacy of drugs for treating rheumatism and rheumatoid arthritis, aiming to overcome the stubborn symptoms of rheumatoid arthritis and contribute to human health.

[0008] This invention's tablets possess properties that clear heat and detoxify, dispel wind and eliminate pathogens; clear damp-heat, dispel wind and unblock meridians; dispel cold and dampness, dispel wind and unblock meridians, replenish qi and invigorate blood, nourish yin and unblock meridians. They can effectively control and treat rheumatoid arthritis. They help eliminate systemic symptoms and exudative inflammation. They can effectively control inflammation in the knee, ankle, shoulder, wrist, elbow, and hip joints affected by rheumatic inflammation, manifesting as local redness, swelling, heat, and pain. The scientifically formulated combination and excellent manufacturing process, through drug development and clinical application, can better comprehensively treat various complications of rheumatoid arthritis. Summary of the Invention

[0009] The purpose of this invention is to provide a safe and effective pure traditional Chinese medicine preparation, a tablet suitable for rheumatoid arthritis that can effectively control rheumatoid arthritis inflammation and is convenient to take, and its preparation method.

[0010] This invention achieves its objective by employing the following technical solution: a tablet suitable for rheumatoid arthritis, comprising formula one, formula two, formula three, and formula four. Formula one is made from the following ingredients in the specified proportions: 100-150 parts of Notopterygium incisum, 80-100 parts of Cinnamomum cassia, 100-150 parts of Angelica pubescens, 100-150 parts of Saposhnikovia divaricata, 30-60 parts of processed Aconitum carmichaelii, and 100-150 parts of Gentiana macrophylla. Formula 2 is made from the following ingredients in the following proportions: 100-150 parts of Anemarrhena asphodeloides, 100-150 parts of Stephania tetrandra, 100-150 parts of Lonicera japonica, 100-150 parts of Scutellaria baicalensis, 100-150 parts of Gardenia jasminoides, 80-100 parts of Phellodendron chinense, 100-150 parts of Smilax glabra, 100-150 parts of Paeonia suffruticosa, and 100-150 parts of Rehmannia glutinosa. Formula 3 is made from the following ingredients in the following proportions: 150 parts raw gypsum, 60-100 parts turtle shell, 60-100 parts licorice root; Formula 3 is made from the following ingredients in the following proportions: 50-100 parts prepared arisaema, 50-100 parts white aconite root, 50-100 parts roasted silkworm pupae, 100-150 parts bee honeycomb, 100-150 parts peach kernel, 50-100 parts safflower, 100-150 parts drynaria rhizome, 100-150 parts dipsacus root, 80-100 parts natural copper. Formula 4 is made from the following ingredients in the following proportions: Angelica sinensis 100-150 parts, Clematis chinensis 150-200 parts, Atractylodes lancea 100-150 parts, Ligusticum chuanxiong 100-150 parts, Angelica dahurica 100-150 parts, Chaenomeles speciosa 150-200 parts, Gentiana scabra 100-150 parts, Salvia miltiorrhiza 100-150 parts, Coix lacryma-jobi 100-150 parts, and Atractylodes macrocephala 100-150 parts.

[0011] Further preferably, the first formulation of the present invention is made from the following raw materials in the specified proportions: 100-130 parts of Notopterygium incisum, 80-100 parts of Cinnamomum cassia, 100-130 parts of Angelica pubescens, 100-130 parts of Saposhnikovia divaricata, 40-50 parts of processed Aconitum carmichaelii, 100-130 parts of Gentiana macrophylla, 100-130 parts of Morus alba, 120-140 parts of Piper kadsura, and 120-140 parts of Spatholobus suberectus; the second formulation... Made from the following ingredients in the specified proportions: Anemarrhena asphodeloides 100-130 parts, Stephania tetrandra 100-130 parts, Lonicera japonica vine 100-130 parts, Scutellaria baicalensis 100-120 parts, Gardenia jasminoides 100-130 parts, Phellodendron chinense 80-90 parts, Smilax glabra 100-130 parts, Paeonia suffruticosa 100-130 parts, Rehmannia glutinosa 100-130 parts, Gypsum fibrosum 60-80 parts, Trionyx sinensis shell 60-80 parts, Glycyrrhiza uralensis 60-80 parts. 0-80 parts; the third formulation is made from the following ingredients in the specified proportions: 60-80 parts of processed Arisaema heterophyllum, 60-80 parts of Aconitum carmichaelii, 60-80 parts of processed Bombyx mori, 100-120 parts of bee honeycomb, 100-120 parts of peach kernel, 60-80 parts of safflower, 100-120 parts of Drynaria fortunei, 100-120 parts of Dipsacus asper, 80-90 parts of natural copper, 20-30 parts of centipede, and 60-80 parts of Zaocys dhumnades. 80 parts; the fourth formulation is made from the following ingredients in the following proportions: Angelica sinensis 100-120 parts, Clematis chinensis 150-180 parts, Atractylodes lancea 100-120 parts, Ligusticum chuanxiong 100-120 parts, Angelica dahurica 100-120 parts, Chaenomeles speciosa 150-180 parts, Gentiana scabra 100-120 parts, Salvia miltiorrhiza 100-120 parts, Coix lacryma-jobi 100-120 parts, Atractylodes macrocephala 100-120 parts.

[0012] A method for preparing a tablet suitable for rheumatoid arthritis, comprising the following steps: (1) Weigh out the raw materials of Formula 1, Formula 2, Formula 3 and Formula 4 according to the proportion requirements, crush them into powder, mix the raw materials of each formula evenly, sieve, fumigate and sterilize to obtain four dry powders, and store them at a constant temperature for later use. (2) Mix the four groups of dry powders obtained in step (1) evenly, sieve them, remove the filter residue that cannot be sieved, and obtain a dry, loose powder with uniform color. (3) Compress the raw material powder obtained in step (2) into tablets to obtain tablets; (4) Package and sterilize the tablets obtained in step (3) to obtain the finished tablets.

[0013] In step (1) of this invention, the four components of the dried powder are stored at a constant temperature of 15–20°C.

[0014] In step (1) of the present invention, fumigation and disinfection involves fumigating 1000g of powder with 80g to 120g of aconite leaves and mugwort leaves for 40 to 60 minutes. The mixing ratio of mugwort leaves and aconite leaves is 80% mugwort leaves and 20% aconite leaves by weight.

[0015] The raw materials and pharmacology in the four sets of prescriptions used in the present invention are as follows: Notopterygium root is the dried rhizome and root of Notopterygium incisum Ting ex H. T. Chang or Notopterygium franchetii H. de Boiss. According to different characters, it is divided into "Silkworm Notopterygium" and "Striped Notopterygium", etc. It is harvested in spring and autumn, the fibrous roots and sediment are removed, and it is dried in the sun. Processing: Remove impurities, wash, moisten until soft, slice, and dry in the sun. Flavor and nature: pungent, bitter, warm. Functions and indications: Dispel wind-cold, remove dampness and relieve pain. Used for wind-cold cold, headache, body pain, and pain in the limbs.

[0016] Ramulus Cinnamomi is the dried tender branch of Cinnamomum cassia Presl. It is harvested in spring and summer, the leaves are removed, and it is dried in the sun or sliced and dried. Processing: Remove impurities, soak slightly, wash, moisten until soft, slice, and air dry. Flavor and nature: pungent, sweet, warm. Functions and indications: Induce sweating to relieve the exterior syndrome, warm and activate the channels. Used for wind-cold cold, muscle and joint pain, amenorrhea and abdominal pain.

[0017] Radix Angelicae Pubescentis is the dried root of Angelica pubescens Maxim. f. biserrata Shan et Yuan. It is harvested when the seedlings just sprout in early spring or when the stems and leaves wither in late autumn. The fibrous roots and sediment are removed, and it is baked until semi-dry, piled up for 2 - 3 days. After it becomes soft, it is baked until completely dry. Processing: Remove impurities, wash, moisten until soft, cut into thin slices, and dry in the sun or by low-temperature drying. Flavor and nature: pungent, bitter, slightly warm. Functions and indications: Dispel wind, remove dampness, dispel cold, and relieve pain. Used for wind-cold-dampness arthralgia, soreness and pain in the waist and knees, rheumatic arthritis pain, and wind-cold headache.

[0018] Radix Saposhnikoviae is the dried root of Saposhnikovia divaricata (Turcz.) Schischk. It is harvested in spring and autumn from the roots of plants without flowering stems. The fibrous roots and sediment are removed, and it is dried in the sun. Processing: Remove impurities, wash, moisten until soft, slice, and dry. Flavor and nature: pungent, sweet, warm. Functions and indications: Induce sweating, disperse wind and eliminate dampness. Used for wind-cold cold, headache, joint pain, skin itching, and urticaria.

[0019] Radix Aconiti is the dried mother root of Aconitum carmichaeli Debx. It is harvested from late June to early August. The lateral roots, fibrous roots and sediment are removed, and it is dried in the sun. Processing: Prepared Radix Aconiti: Take the clean Radix Aconiti, separate the large and small ones, soak them in water or saturated quicklime water until there is no dry core inside, take them out, add water and boil for 4 - 6 hours. When cutting the large and solid ones and there is no white core inside and there is a slight numb feeling on the tongue when tasting, take them out, air dry until 60% dry or moisten and slice, and then dry. Flavor and nature: pungent, bitter, hot; highly toxic. Functions and indications: Dispel wind-dampness, dispel cold, and relieve pain. Used for wind-cold-dampness arthralgia, cold pain in the limbs and joints, sciatica, and severe pain from falls and bruises.

[0020] Gentian root (Qin Jiao) is the dried root of *Gentiana macrophylla*, *Gentiana sessiliflora*, *Gentiana stoutensis*, or *Gentiana minor*, all belonging to the Gentianaceae family. The first three are commonly known as "Gentiana macrophylla" and "sessiliflora" respectively, while the last is commonly known as "minor Gentiana." Harvested in spring and autumn, the roots are cleaned of mud and sand. *Gentiana macrophylla* and *sessiliflora* are softened by sun-drying, then piled up to "sweat" until the surface turns reddish-yellow or grayish-yellow, before being spread out to dry in the sun, or dried directly without "sweating." *Minor Gentiana minor* is dried while fresh, after rubbing off the black outer skin. Processing: Remove impurities, wash, moisten thoroughly, slice, and sun-dry. Properties: Bitter, pungent, neutral. Functions and Indications: Dispels wind and dampness, reduces deficiency fever, and relieves pain. Used for rheumatoid arthritis, low-grade fever, and infantile malnutrition with fever.

[0021] Mulberry twigs are the dried tender branches of the mulberry tree (Morus alba), a plant in the Moraceae family. They are harvested in late spring and early summer, leaves removed, and sun-dried, or sliced ​​while fresh and sun-dried. Processing: For unsliced ​​mulberry twigs, wash, moisten thoroughly, slice, and sun-dry. For stir-fried mulberry twigs: take mulberry twig slices and stir-fry using the traditional stir-frying method until slightly yellow. Properties: Slightly bitter, neutral. Functions and indications: Dispels wind and dampness, benefits joints. Used for shoulder, arm, and joint pain and numbness.

[0022] Piper kaempferia, or sea breeze vine, is the dried stem of the piper plant Piper kaempferia. It is harvested in summer and autumn, the roots and leaves are removed, and it is sun-dried. Processing: Remove impurities, soak until thoroughly moistened, slice, and sun-dry. Properties: Pungent, slightly warm. Functions and indications: Dispels wind and dampness, unblocks meridians, and relieves pain. Used for wind-cold-dampness arthralgia, joint pain, and difficulty in bending and straightening the waist and knees.

[0023] Chicken blood vine (Chicken Blood Vine) is the dried vine stem of *Mammillaria micrantha*, a legume. It is harvested in autumn and winter, the branches and leaves are removed, it is sliced, and sun-dried. Processing: Remove impurities, wash, moisten thoroughly, chop, and sun-dry. Properties: Sweet, astringent, neutral. Functions and indications: Promotes blood circulation, nourishes blood, and unblocks meridians; used for numbness and paralysis of limbs, lower back and knee pain, irregular menstruation, and anemia.

[0024] Formula 2: Anemarrhena asphodeloides is the dried rhizome of the plant *Anemarrhena asphodeloides*, belonging to the Liliaceae family. It is harvested in spring and autumn, the fibrous roots and dirt are removed, and it is sun-dried, commonly known as "hairy Anemarrhena asphodeloides"; the outer skin is removed, and it is sun-dried, commonly known as "Anemarrhena asphodeloides flesh". Processing: Remove impurities, wash, moisten thoroughly, slice or segment, and sun-dry. Properties: Bitter, cold. Functions and indications: Clears heat and detoxifies, cools the blood. Used for dysentery, hemorrhoidal bleeding, carbuncles and boils.

[0025] Fangji (Stephania tetrandra) is the dried root of the plant Stephania tetrandra in the Menispermaceae family. It is harvested in autumn, washed, the outer bark removed, and sun-dried until semi-dry. It is then cut into sections, with larger roots further cut longitudinally and dried. Processing: Remove impurities, soak briefly, wash, moisten thoroughly, slice, and dry; remove impurities, soak briefly, wash, moisten thoroughly, slice, and dry. Properties: Bitter, cold. Functions and indications: Promotes diuresis, dispels wind, reduces swelling, relieves pain, lowers blood pressure; used for edema, difficulty urinating, limb pain, rheumatoid arthritis, carbuncles, eczema, and lower limb ulcers.

[0026] Honeysuckle vine is the dried stem and branches of *Lonicera japonica*, a plant in the Caprifoliaceae family. It is harvested in autumn and winter and dried in the sun. Processing: Remove impurities, wash, moisten, cut into sections, and dry. Properties: Sweet, cold. Functions and indications: Clears heat and detoxifies, unblocks meridians. Used for febrile diseases, joint redness, swelling and pain, carbuncles and sores.

[0027] Scutellaria baicalensis is the dried root of the plant Scutellaria baicalensis, belonging to the Lamiaceae family. It is harvested in spring and autumn. After removing the fibrous roots and dirt, it is sun-dried, the outer skin is removed by pounding, and then it is dried completely. Processing: Remove impurities, boil in boiling water for 10 minutes, remove, let it steep thoroughly, slice, and dry; or steam for 1 hour, remove, slice, and dry. Wine-processed Scutellaria baicalensis: Take Scutellaria baicalensis slices and lightly stir-fry with rice wine as in wine-frying. Properties: Bitter, cold. Functions and indications: Clears damp-heat, drains fire, detoxifies, and calms the fetus. Used for febrile diseases, lung-heat cough, pneumonia, hemoptysis, jaundice, hepatitis, dysentery, conjunctivitis, threatened abortion, hypertension, carbuncles, boils, and sores.

[0028] Gardenia, the dried, ripe fruit of *Gardenia spp.*, a plant in the Rubiaceae family. It is harvested from September to November when the fruit is ripe and turns reddish-yellow. Remove the fruit stalks and impurities, steam until steam rises or briefly blanch in boiling water, then remove and dry. Processing methods: Gardenia: Remove impurities and crush. Fried Gardenia: Take clean gardenia and fry until yellowish-brown. Charred Gardenia: Take clean gardenia and fry until yellowish-brown. Properties: Bitter, cold. Functions and indications: Clears heat and relieves irritability, cools blood and promotes diuresis, cools blood and disperses blood stasis. Used for feverish irritability, jaundice, red eyes, epistaxis, hematemesis, hematuria, and carbuncles due to heat toxins; externally used for sprains, contusions, and swelling due to blood stasis.

[0029] Phellodendron bark is the dried bark of the phellodendron amurense or Phellodendron chinense, both belonging to the Rutaceae family. The former is commonly known as "Sichuan Phellodendron," and the latter as "Guan Phellodendron." After peeling the bark, the outer bark is removed, and the bark is sun-dried. Processing: Phellodendron bark: Remove impurities, spray with water to moisten thoroughly, cut into shreds, and sun-dry. Salted Phellodendron: Take the shredded Phellodendron bark and lightly stir-fry with salt water according to the salt water roasting method. Properties: Bitter, cold. Functions and indications: Clears heat and detoxifies, clears damp-heat. Used for urinary tract infections, prostatitis, jaundice, dysentery, enteritis, damp-heat weakness and paralysis, leukorrhea, and hemorrhoids; externally used for sores, canker sores, eczema, impetigo, burns, and scalds.

[0030] Smilax glabra, the dried rhizome of *Smilax glabra*, a plant in the Liliaceae family. It is harvested in summer and autumn, the fibrous roots are removed, it is washed, and dried, or sliced ​​thinly while fresh and then dried. Preparation: Remove impurities; for unsliced ​​rhizomes, soak, wash, and thoroughly moisten, then slice and dry. Properties: Sweet, bland, neutral. Functions and indications: Clears heat, eliminates dampness, and detoxifies. Used for leptospirosis, joint pain, urinary tract infections, leukorrhea, and sores.

[0031] Moutan bark is the dried root bark of the peony plant (Paeonia suffruticosa), belonging to the Ranunculaceae family. The roots are harvested in autumn, the fine roots are removed, the root bark is peeled off, and then dried in the sun. Preparation: Quickly wash clean, moisten, slice, and sun-dry. Properties: Bitter, pungent, slightly cold. Functions and indications: Clears blood heat and disperses blood stasis. Used for febrile diseases with rashes, rashes, hematemesis, epistaxis, tidal fever, dysmenorrhea, amenorrhea, and carbuncles.

[0032] Rehmannia root (Shengdihuang) is the fresh or dried tuberous root of Rehmannia glutinosa, a plant in the Scrophulariaceae family. It is harvested in autumn, the rhizome and fibrous roots are removed, and it is washed clean. Freshly used root is commonly called "fresh Shengdi." When fresh Shengdi is slowly baked until about 80% dry, it is formed into clumps, also known as "Shengdi." Processing: Remove impurities, wash, moisten, slice, and dry. Charred Shengdi: Take Shengdi slices and charcoal them using the same method as for charcoal frying until they puff up. Properties: Sweet, cold. Functions and indications: Clears heat, cools blood, promotes body fluid production. Used for feverish irritability, rashes, low-grade fever due to yin deficiency, thirst, hematemesis, epistaxis, hematuria, and metrorrhagia.

[0033] Raw gypsum is a monoclinic gypsum ore, mainly containing hydrated calcium sulfate. After mining, mud, sand, and impurities are removed. Processing: Raw gypsum: Wash clean, dry in the sun, crush, remove impurities, and grind into coarse powder. Calcined gypsum: Take clean gypsum and calcine it according to the calcination method until it turns red-hot. Properties: Sweet, pungent, very cold. Functions and indications: When used raw, it clears heat and drains fire, relieves irritability and quenches thirst; when calcined, it promotes tissue regeneration and wound healing. Used for high fever, profuse sweating, thirst, irritability, cough and asthma due to lung heat, headache due to stomach fire, and toothache; externally used for non-healing ulcers, eczema, burns, and scalds.

[0034] Turtle shell, the carapace of the turtle (Trionyx sinensis). It can be caught year-round, but is most abundant in autumn and winter. After capture, kill the turtle and scald it in boiling water until the hard outer layer of the carapace can be peeled off. Remove it, peel off the carapace, remove any remaining flesh, and sun-dry. Processing: Soak, remove the skin and flesh, sun-dry and dew-expose until there is no odor. Vinegar-processed turtle shell: Take clean turtle shell, stir-fry with sand using the scalding method until the surface is light yellow, remove, sift out the sand, quench in vinegar, remove, and sun-dry. Properties: Salty, slightly cold. Functions and indications: Nourishes Yin and reduces fever, softens hard masses and dissipates nodules; used for Yin deficiency with tidal fever, night sweats, convulsions due to Yin deficiency in the later stages of febrile diseases, abdominal masses, hepatosplenomegaly, and amenorrhea.

[0035] Licorice is the dried root and rhizome of *Glycyrrhiza uralensis*, *Glycyrrhiza inflata*, or *Glycyrrhiza glabra*, all belonging to the legume family. It is harvested in spring and autumn, the fibrous roots are removed, and it is sun-dried. Processing: Licorice: Remove impurities, wash, moisten thoroughly, slice, and dry. Honey-processed licorice: Take licorice slices, stir-fry with honey water until yellow, and let cool until no longer sticky. Functions and indications: Clears heat and detoxifies, relieves cough and eliminates phlegm, tonifies the spleen and stomach, and harmonizes other herbs. Used for sore throat, cough, palpitations, abdominal pain due to deficiency, ulcers, and sores.

[0036] Formula 3: Prepared Arisaema is the dried tuber of Arisaema heterophyllum, Arisaema heterophyllum, or Arisaema davidii, all belonging to the Araceae family. It is harvested in autumn and winter when the stems and leaves wither. The fibrous roots and outer skin are removed, and it is then dried. Processing: Raw Arisaema: Remove impurities, wash, and sun-dry. Prepared Arisaema: Take clean Arisaema, separate by size, and soak in water, changing the water 2-3 times daily. If white foam appears, add 2 kg of alum to 100 kg of Arisaema daily, soaking for one day, then changing the water again. Continue soaking until a slightly numbing and spicy sensation is felt in the taste, then remove. Properties: Bitter, pungent, warm, toxic. Functions and Indications: Dispels wind and calms convulsions, resolves phlegm, and disperses nodules. Used for stroke, facial paralysis, hemiplegia, etc.

[0037] White aconite (Bai Fu Zi) is the dried tuber of *Arisaema heterophyllum*, a plant in the Araceae family. It is harvested in autumn, the fibrous roots and outer skin are removed, and it is fumigated with sulfur 1-2 times before being sun-dried. Processing: Raw white aconite: Remove impurities. Processed white aconite: Take clean white aconite, separate by size, soak, changing the water 2-3 times daily. After several days, if it becomes sticky, change the water and add a small amount of alum, soak for another day, then change the water again. Soak until it tastes slightly numbing and spicy, then remove it. Add crushed ginger, alum, and appropriate amount of water, boil thoroughly, remove, and air-dry until 60% dry, slice, and dry completely. For every 100kg of white aconite, use 25kg of ginger and 12.5kg of alum. Properties: Pungent, sweet, very warm, toxic. Functions and indications: Dispels wind-phlegm, relieves spasms. Used for stroke with facial paralysis, migraine, tetanus, lymph node tuberculosis, and carbuncles.

[0038] Roasted silkworm larvae (Bombyx mori) are the dried bodies of 4th-5th instar silkworm larvae infected (or artificially inoculated) with Beauveria bassiana and killed. Production is mostly in summer, involving drying silkworms that have died from Beauveria bassiana infection. Processing: Remove impurities from the roasted silkworm larvae. Stir-fry the roasted silkworm larvae: Take cleaned roasted silkworm larvae and stir-fry them using the same method as stir-frying wheat bran until the surface turns yellow. Properties: Salty, pungent, neutral. Functions and Indications: Dispels wind and calms convulsions, resolves phlegm and dissipates nodules. Used for infantile convulsions, sore throat, submandibular adenitis, facial nerve paralysis, and pruritus.

[0039] Beehives are the nests of common long-legged wasps, Japanese long-legged wasps, or heterocercus wasps. They are harvested in autumn and winter, sun-dried, or slightly steamed, with dead wasps and pupae removed, and then sun-dried again. Processing: Remove impurities and cut into pieces. Properties: Sweet, neutral; slightly toxic. Functions and indications: Dispels wind, attacks toxins. Used for pruritus, acute mastitis, lymph node tuberculosis, infantile convulsions, toothache, carbuncles and boils, fistulas, tinea pedis, and swelling and pain from bee stings.

[0040] Peach kernel is the dried, mature seed of the peach or wild peach plant (Prunus persica), belonging to the Rosaceae family. Mature fruits are harvested in summer and autumn, or the kernels are collected. The pulp and shell are removed, the seeds are extracted, and then dried in the sun. Processing: Impurities are removed, and the kernels are boiled in boiling water until the outer skin is slightly wrinkled. They are then removed, soaked in cold water, peeled, and dried in the sun. Properties: Bitter, sweet, neutral. Functions and indications: Promotes blood circulation, removes blood stasis, and moistens the intestines. Used for amenorrhea, dysmenorrhea, abdominal masses, traumatic injuries, and constipation due to intestinal dryness.

[0041] Safflower, the dried flower of *Carthamus tinctorius*, a plant in the Asteraceae family. It is harvested in summer when the flowers turn from yellow to red, and then dried in the shade or sun. Processing: The corolla tube is slender, and the stigma is long and cylindrical, slightly forked at the apex. It is soft in texture. It has a slightly fragrant odor and a slightly bitter taste. The best quality is characterized by its bright reddish-yellow color and soft texture. Properties: Pungent, warm. Functions and indications: Promotes blood circulation, removes blood stasis, and regulates menstruation. Used for amenorrhea, dysmenorrhea, lochia retention, abdominal masses, and injuries from falls.

[0042] Drynaria fortunei, the dried rhizome of *Dryopteris crassirhizoma* or *Dryopteris sinensis*, both belonging to the Polypodiaceae family. It can be harvested year-round. After removing dirt and sand, it is dried, or the hairs (scales) may be singed off. Processing: Drynaria fortunei: Remove impurities, wash, moisten thoroughly, slice, and dry. Stir-fried Drynaria fortunei: Take clean Drynaria fortunei or slices, stir-fry with sand using the scalding method until it puffs up and the hairs turn a dark yellow color, then let cool and remove the hairs. Properties: Bitter, warm. Functions and indications: Tonifies the kidneys, strengthens bones, invigorates blood circulation, and relieves pain. Used for injuries from falls, loose teeth, tinnitus; externally for alopecia areata.

[0043] Dipsacus root, the dried root of *Dipsacus asper*, a plant in the Dipsacaceae family, is harvested in autumn. The root head and fibrous roots are removed, and the roots are dried over a low flame until semi-dry. They are then piled up to "sweat" until the inside turns green, and then dried completely. Preparation: Wash thoroughly, moisten, slice thinly, and dry. Properties: Bitter, pungent, sweet, slightly warm. Functions and indications: Tonifies the liver and kidneys, promotes bone and tendon healing, stops bleeding, and relieves pain. Used for lower back and knee weakness, joint pain, metrorrhagia, threatened abortion, and injuries from falls.

[0044] Native copper is mostly cube-shaped, with a diameter of 0.2–2.5 cm. The surface is bright yellow with a metallic luster; some are yellowish-brown or brownish-black without a metallic luster; they have fine blackish-brown or dark green streaks and pinholes. It is heavy, hard or slightly brittle, and easily broken. The fracture surface is yellowish-white with a metallic luster, or brownish-black with visible silvery-white specks. It is odorless and tasteless. The best quality is characterized by neat, bright yellow pieces with a metallic luster on the fracture surface. Processing: Calcined native copper is calcined according to the calcination method until it is red-hot, then immediately immersed in vinegar for quenching. It is then removed, calcined again, and quenched in vinegar until the color turns blackish-brown, the surface luster disappears, and it becomes brittle. For every 100 kg of native copper, use 25–30 kg of vinegar. Properties: Pungent, neutral. Functions and indications: Disperses blood stasis, promotes bone healing, relieves pain; used for swelling and pain from falls and fractures.

[0045] Centipede, specifically the dried body of *Scolopendra subspinipes*, an animal of the Scolopendra family. It is captured in spring and summer, its head and tail are inserted into bamboo strips to straighten it, and then it is dried. Properties: pungent, warm; poisonous. Functions and indications: calms wind and relieves spasms, dispels wind and attacks toxins. Used for infantile convulsions, spasms and convulsions, facial nerve paralysis, tetanus, bone tuberculosis, lymph node tuberculosis, and slow-healing ulcers and fistulas.

[0046] The Chinese black-banded snake (Zaocys dhumnades) refers to the entire body of the snake (Zaocys dhumnades) removed from its internal organs. This animal is distributed in Shaanxi, Gansu, Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Henan, Hubei, Hunan, Guangdong, Guangxi, Sichuan, and Guizhou provinces of my country. It is believed to have the effects of dispelling wind and dampness, clearing the meridians, and relieving spasms. It is mainly used to treat stubborn rheumatism, numbness of the skin, muscle contractures, limb paralysis, tetanus, leprosy, urticaria, and scabies.

[0047] Formula 4: Angelica sinensis, the dried root of the angelica sinensis plant (Apiaceae family), is harvested in late autumn. After removing fibrous roots and dirt, and allowing some moisture to evaporate, it is bundled into small bunches, placed on a rack, and slowly dried using smoke. Processing: Remove impurities from the angelica root, wash it, moisten it thoroughly, slice it, and sun-dry or dry it at low temperature. Properties: Sweet, pungent, warm. Functions and indications: Nourishes and invigorates blood, regulates menstruation and relieves pain; used for anemia, irregular menstruation, amenorrhea, dysmenorrhea, metrorrhagia; also used for postpartum abdominal pain, constipation due to blood deficiency, traumatic injuries, and sores due to blood stasis.

[0048] Clematis chinensis, the dried root and rhizome of Clematis chinensis, Clematis armandii, or Clematis davidii (Ranunculaceae family). Harvested in autumn, cleaned of dirt and sand, and sun-dried. Processing: Remove impurities, wash, moisten thoroughly, cut into sections, and dry. Properties: Pungent, salty, warm. Functions and indications: Dispels wind and dampness, relieves pain, and unblocks meridians. Used for rheumatic joint pain, lower back and knee pain, and bone obstruction in the throat.

[0049] Atractylodes lancea is the dried rhizome of Atractylodes lancea or Atractylodes dasycarpus, both belonging to the Asteraceae family. It is harvested in spring and autumn, cleaned of dirt and sand, sun-dried, and the fibrous roots removed. Processing: Atractylodes lancea: Remove impurities, wash, moisten thoroughly, slice, and dry. Stir-fried Atractylodes lancea: Take slices of Atractylodes lancea and stir-fry until slightly yellow. Properties: Pungent, bitter, warm. Functions and indications: Dries dampness, strengthens the spleen, improves eyesight. Used for abdominal distension, vomiting and diarrhea, edema, phlegm retention, heaviness and soreness of limbs and joints, and night blindness.

[0050] Chuanxiong (Ligusticum striatum) is the dried rhizome of the plant *Ligusticum chuanxiong*, belonging to the Apiaceae family. It is harvested in summer when the nodes on the stem are prominently protruding and slightly purplish. After removing dirt and sand, it is sun-dried and then oven-dried, removing the fibrous roots. Processing: Remove impurities, separate by size, soak briefly, wash, moisten thoroughly, slice thinly, and dry. Properties: Pungent, slightly bitter, warm. Functions and Indications: Promotes blood circulation and menstruation, dispels wind and relieves pain; used for headaches, chest and rib pain, amenorrhea and abdominal pain, rheumatic pain, and injuries from falls.

[0051] Angelica dahurica is the dried root of Angelica dahurica or Angelica dahurica var. chinensis, both belonging to the Apiaceae family. It is harvested in summer and autumn when the leaves turn yellow. The fibrous roots and dirt are removed, and it is sun-dried or dried at low temperature. Processing: Impurities are removed, and the roots are separated by size. They are briefly soaked until fully hydrated, sliced, and then dried. Properties: Pungent, warm. Functions and indications: Dispels wind and dampness, drains pus and relieves pain; used for headaches due to colds, nasal congestion, supraorbital neuralgia, rhinitis, sinusitis, toothache, leukorrhea, carbuncles, and sores.

[0052] Papaya, the dried or ripe fruit of the rose plant Chaenomeles speciosa or Chaenomeles japonica. The former is commonly known as "wrinkled-skin papaya," and the latter as "smooth-skin papaya." The fruit is harvested in summer and autumn when it is greenish-yellow. Wrinkled-skin papaya is blanched in boiling water until the outer skin turns grayish-white, then longitudinally halved and sun-dried. Smooth-skin papaya is longitudinally halved into two or four segments, blanched in boiling water, and then sun-dried. Preparation: Wash clean, moisten thoroughly or steam thoroughly, then slice and sun-dry. Properties: Sour, warm. Functions and indications: Relieves muscle spasms, dispels dampness, harmonizes the stomach. Used for gastrocnemius muscle spasms, vomiting and diarrhea with abdominal pain, and rheumatic joint pain.

[0053] Gentian is the dried root and rhizome of the gentian plants *Gentiana linearifolia*, *Gentiana scabra*, *Gentiana triflora*, or *Gentiana scabra*. The first three are commonly referred to as "gentian," while the last is commonly called "gentiana scabra." It is harvested in spring and autumn, washed, and dried. Processing: Remove impurities, wash, moisten thoroughly, cut into sections, and dry. Properties: Bitter, cold. Functions and indications: Clears damp-heat from the liver and gallbladder, strengthens the stomach. Used for jaundice, hypochondriac pain, pneumonia, cholecystitis, loss of appetite, red eyes, otitis media, urinary tract infection, herpes zoster, acute eczema, and genital itching.

[0054] Salvia miltiorrhiza, the dried root and rhizome of the plant Salvia miltiorrhiza (Lamiaceae family). Harvested in spring and autumn, the roots and rhizomes are cleaned of dirt and dried. Processing: Impurities and residual stems are removed, the roots are washed, moistened, sliced, and dried. Properties: Bitter, slightly cold. Functions and indications: Removes blood stasis and relieves pain, invigorates blood and regulates menstruation. Used for irregular menstruation, amenorrhea, ectopic pregnancy, hepatosplenomegaly, angina pectoris, insomnia, and carbuncles and boils.

[0055] Job's tears (Coix seed) is the dried, mature seed of the grass *Coix lacryma-jobi*. The plants are harvested in autumn when the fruit is ripe, dried in the sun, the fruit is threshed, dried again, and the outer shell and yellowish-brown seed coat are removed to collect the kernels. Processing: Job's tears: Remove impurities. Stir-fried Job's tears: Take clean Job's tears and stir-fry until slightly yellow. Properties: Sweet, bland, slightly cold. Functions and indications: Strengthens the spleen, eliminates dampness, drains pus. Used for spleen deficiency diarrhea, muscle soreness and heaviness, joint pain, edema, leukorrhea, lung abscess, and appendicitis.

[0056] Atractylodes macrocephala is the dried rhizome of the plant Atractylodes macrocephala, belonging to the Asteraceae family. It is harvested in winter when the lower leaves turn yellow and the upper leaves become brittle. After harvesting, the rhizome is cleaned of dirt and sand, dried by baking or sun-drying, and the fibrous roots are removed. Processing: Atractylodes macrocephala: Remove impurities, wash, moisten thoroughly, slice, and dry. Stir-fried Atractylodes macrocephala: Take slices of Atractylodes macrocephala and stir-fry using the method for stir-frying with wheat bran until the color darkens. Properties: Sweet, bitter, warm. Functions and indications: Strengthens the spleen and dries dampness. Used for spleen deficiency with poor appetite, abdominal distension, diarrhea, phlegm retention with dizziness, edema, and threatened abortion.

[0057] Based on the pathogenesis of rheumatoid arthritis, this invention scientifically combines various Chinese medicinal materials through thorough analysis of their pharmacological properties. This maximizes the pharmacological effects of each component, achieving the effects of clearing heat and detoxifying, dispelling wind and eliminating pathogens; clearing damp-heat, dispelling wind and unblocking the meridians; dispelling cold and dampness, dispelling wind and unblocking the meridians; tonifying qi and activating blood, nourishing yin and unblocking the meridians. This invention can effectively control the local inflammatory manifestations of redness, swelling, heat, and pain in the knee, ankle, shoulder, wrist, elbow, and hip joints affected by rheumatic inflammation, and helps eliminate systemic symptoms and exudative inflammation. Clinical application has proven that this invention can effectively treat various complications of rheumatoid arthritis.

[0058] By adopting the above technical solution, the present invention has achieved its purpose well. It uses pure Chinese medicine products as raw materials, and the formula is reasonable. The combination of various medicines can dispel wind and dampness, unblock the meridians and relieve pain, clear heat and dispel cold. Patients can take it directly orally when rheumatoid arthritis occurs, which is convenient to use. Detailed Implementation

[0059] The present invention will be further described below with reference to the embodiments. Example 1

[0060] A tablet for rheumatoid arthritis is made from four formulations: Formulation 1, Formulation 2, Formulation 3, and Formulation 4. Formulation 1 is made from the following ingredients in the specified proportions: 100 parts Notopterygium root, 80 parts Cinnamon twig, 100 parts Angelica pubescens root, 100 parts Saposhnikovia root, 30 parts Prepared Aconitum carmichaelii root, 100 parts Gentiana macrophylla root, 100 parts Mulberry twig, 120 parts Piper kadsura stem, and 120 parts Spatholobus stem. Formulation 2 is made from the following ingredients in the specified proportions: 100 parts Anemarrhena rhizome, 100 parts Stephania tetrandra root, 100 parts Lonicera japonica stem, 100 parts Scutellaria baicalensis root, 100 parts Gardenia fruit, 80 parts Phellodendron bark, 100 parts Smilax glabra root, 100 parts Paeonia suffruticosa root bark, and 100 parts Rehmannia glutinosa root. Formula 3 is made from the following ingredients: 60 parts raw gypsum, 60 parts turtle shell, and 60 parts licorice; Formula 4 is made from the following ingredients: 50 parts prepared arisaema, 50 parts white aconite, 50 parts roasted silkworm, 100 parts bee honeycomb, 100 parts peach kernel, 50 parts safflower, 100 parts drynaria rhizome, 100 parts dipsacus root, 80 parts natural copper, 20 parts centipede, and 50 parts black-striped snake; Formula 5 is made from the following ingredients: 100 parts angelica root, 150 parts clematis root, 100 parts atractylodes rhizome, 100 parts chuanxiong rhizome, 100 parts angelica dahurica root, 150 parts papaya, 100 parts gentian root, 100 parts salvia miltiorrhiza root, 100 parts coix seed, and 100 parts atractylodes rhizome.

[0061] A method for preparing a tablet suitable for rheumatoid arthritis, comprising the following steps: (1) Weigh each raw material of Formula 1, Formula 2, Formula 3 and Formula 4 according to the required proportions, crush them into powder, mix the raw materials of each formula evenly, sieve, fumigate and sterilize to obtain four dry powders, and store them at a constant temperature of 18℃ for later use. (2) Mix the four groups of dry powders obtained in step (1) evenly, sieve them, remove the filter residue that cannot be sieved, and obtain a dry, loose powder with uniform color. (3) Compress the raw material powder obtained in step (2) into tablets to obtain tablets; (4) Take the tablets obtained in step (3), 0.4 g each, package them, and sterilize them to obtain the finished tablets.

[0062] In step (1) of this embodiment, fumigation disinfection involves mixing 100g of powder with 20% aconite leaves and 80% mugwort leaves, for a total of 100g, and fumigating for 60 minutes. Example 2

[0063] A tablet for rheumatoid arthritis, comprising Formula 1, Formula 2, Formula 3, and Formula 4. Formula 1 is made from the following ingredients in the specified proportions: 120 parts Notopterygium root, 100 parts Cinnamon twig, 120 parts Angelica pubescens root, 120 parts Saposhnikovia root, 30 parts Prepared Aconitum carmichaelii root, 120 parts Gentiana macrophylla root, 120 parts Mulberry twig, 140 parts Piper kadsura stem, and 140 parts Spatholobus stem. Formula 2 is made from the following ingredients in the specified proportions: 120 parts Anemarrhena rhizome, 120 parts Stephania tetrandra root, 120 parts Lonicera japonica stem, 100 parts Scutellaria baicalensis root, 120 parts Gardenia fruit, 90 parts Phellodendron bark, 120 parts Smilax glabra root, 120 parts Moutan bark, 120 parts Rehmannia glutinosa root, and raw... Formula 3 is made from the following ingredients in the following proportions: 80 parts gypsum, 80 parts turtle shell, and 60 parts licorice; Formula 4 is made from the following ingredients in the following proportions: 60 parts prepared arisaema, 60 parts white aconite, 80 parts roasted silkworm, 120 parts bee honeycomb, 120 parts peach kernel, 60 parts safflower, 120 parts drynaria rhizome, 120 parts dipsacus root, 90 parts natural copper, 20 parts centipede, and 60 parts black-striped snake; Formula 5 is made from the following ingredients in the following proportions: 120 parts angelica root, 180 parts clematis root, 120 parts atractylodes rhizome, 120 parts chuanxiong rhizome, 120 parts angelica dahurica root, 180 parts papaya, 120 parts gentian root, 120 parts salvia miltiorrhiza root, 120 parts coix seed, and 120 parts atractylodes rhizome.

[0064] In this embodiment, the dried powder is stored at a constant temperature of 20°C.

[0065] Same as Example 1. Example 3

[0066] A tablet for rheumatoid arthritis, comprising Formula 1, Formula 2, Formula 3, and Formula 4. Formula 1 is made from the following ingredients in the specified proportions: 130 parts Notopterygium root, 90 parts Cinnamon twig, 130 parts Angelica pubescens root, 130 parts Saposhnikovia root, 45 parts Prepared Aconitum carmichaelii root, 130 parts Gentiana macrophylla root, 130 parts Mulberry twig, 130 parts Piper kadsura stem, and 130 parts Spatholobus stem. Formula 2 is made from the following ingredients in the specified proportions: 130 parts Anemarrhena rhizome, 130 parts Stephania tetrandra root, 130 parts Lonicera japonica stem, 110 parts Scutellaria baicalensis root, 130 parts Gardenia fruit, 90 parts Phellodendron bark, 130 parts Smilax glabra rhizome, 130 parts Moutan bark, 130 parts Rehmannia glutinosa root, and raw... Formula 3 is made from the following ingredients in the following proportions: 80 parts gypsum, 80 parts turtle shell, and 80 parts licorice; Formula 4 is made from the following ingredients in the following proportions: 70 parts prepared arisaema, 70 parts white aconite, 70 parts roasted silkworm, 120 parts bee honeycomb, 120 parts peach kernel, 70 parts safflower, 120 parts drynaria rhizome, 120 parts dipsacus root, 80 parts natural copper, 25 parts centipede, and 70 parts black-striped snake; Formula 5 is made from the following ingredients in the following proportions: 130 parts angelica root, 180 parts clematis root, 120 parts atractylodes rhizome, 120 parts chuanxiong rhizome, 120 parts angelica dahurica root, 170 parts papaya, 120 parts gentian root, 120 parts salvia miltiorrhiza root, 120 parts coix seed, and 120 parts atractylodes rhizome.

[0067] In this embodiment, the dried powder is stored at a constant temperature of 18°C.

[0068] In this embodiment, fumigation disinfection involves mixing 20% ​​aconite leaves and 80% mugwort leaves (totaling 120g) of powder and fumigating for 40 minutes.

[0069] Same as Example 1. clinical trials

[0070] Traditional Chinese medicine has rich clinical experience in the diagnosis and treatment of rheumatoid arthritis. It usually classifies patients into four types based on their clinical symptoms and manifestations: wind-cold-dampness type, wind-damp-heat type, phlegm-blood stasis type, and qi-yin deficiency type. Different prescriptions are used for treatment, as shown in Table 1.

[0071] Table 1. Clinical studies on the TCM syndrome differentiation and treatment of rheumatoid arthritis Experimental Example 1

[0072] A clinical trial was conducted on 390 patients with rheumatoid arthritis (200 males and 190 females) using the finished tablets prepared in Example 1. The dosage was 3 tablets orally three times daily for 30 days as one course of treatment, continued for 3-5 months. Patients were evaluated based on their condition after treatment, with results including marked efficacy, effectiveness, and ineffectiveness. The specific diagnostic criteria for marked efficacy, effectiveness, and ineffectiveness were as follows: Significant effect: Disappearance of joint or muscle soreness, changes in joint shape and restoration of function; Effective: Pain is reduced, and joint shape returns to normal; Ineffective: After 5 courses of treatment (30 days per course), the symptoms did not improve.

[0073] Table 2. Statistical analysis of the efficacy of the tablets of this invention in treating rheumatoid arthritis.

[0074] After five courses of treatment, the patients' medication results were tracked, and the efficacy was evaluated according to the above evaluation criteria, as detailed in Table 2. Table 2 shows that 172 male patients (86%) showed significant improvement, and 166 female patients (87.37%) showed improvement, with the female rate significantly higher than the male rate. By age group: 61 patients (87.14%) in the 15-30 age group showed improvement; 77 patients (87.5%) in the 41-50 age group showed no improvement; and 6 patients (10.19%) in the 61-70 age group showed no improvement, significantly higher than the 15-30 age group (2 female patients, 3.57%). This indicates that younger patients have higher rates of significant improvement and efficacy. The efficacy analysis shows that among the patients with significant improvement, 166 female patients (87.37%) showed improvement, higher than the 172 male patients (86%). This suggests that the improvement in rheumatoid arthritis in male patients is related to their lifestyle habits, such as smoking, drinking alcohol, and heavy physical labor. Experimental Example 2

[0075] 222 patients with rheumatoid arthritis were selected and divided into two groups: an experimental group of 112 people and a control group of 110 people. The experimental group took the tablets prepared in Example 2 of this invention, 3 tablets (0.4g each) 3 times a day; the control group took Tripterygium wilfordii tablets, 1 tablet 3 times a day. Each course of treatment was 30 days, and the treatment lasted for 4 to 6 months.

[0076] Table 3. Clinical controlled trials of the tablets and Tripterygium wilfordii tablets of the present invention in the treatment of rheumatoid arthritis.

[0077] After five courses of treatment, the patients' medication results were tracked. The efficacy of the medication was evaluated in both the experimental and control groups according to the aforementioned evaluation criteria (see Table 3). The results showed that in the experimental group of 112 patients, 95 cases (89.82%) showed significant efficacy, 10 cases (8.9%) showed efficacy, and 9 cases (8.0%) showed no efficacy. In the control group of 110 patients, 86 cases (78.18%) showed significant efficacy, 10 cases (9.1%) showed efficacy, and 12 cases (10.1%) showed no efficacy. Table 3 shows that the tablets of this invention were effective in treating 105 cases of rheumatoid arthritis, with an effective rate of 98.7%, significantly higher than the 87.28% in the control group. In the experimental group, 44 cases (95.65%) showed significant efficacy in the pre-elderly stage, significantly higher than the 26 cases (86.67%) in the advanced elderly stage. In the control group, 39 cases (88.64%) showed significant efficacy in the pre-elderly stage and 25 cases (83.33%) in the advanced elderly stage. This demonstrates that in the elderly, due to aging, immune function declines and adaptability decreases. Aging causes changes in the body's structure and function, which inevitably lead to changes in pharmacokinetics in the elderly, namely, changes in drug absorption, distribution, metabolism, and excretion. Correspondingly, the intensity, duration, and even the nature of drug action may change. The high incidence of adverse reactions after drug use in the elderly is also closely related to changes in pharmacokinetics.

Claims

1. A tablet suitable for rheumatoid arthritis, characterized in that It is composed of Formula 1, Formula 2, Formula 3, and Formula 4. Formula 1 is made from the following ingredients in the specified proportions: 100-150 parts of Notopterygium incisum, 80-100 parts of Cinnamomum cassia, 100-150 parts of Angelica pubescens, 100-150 parts of Saposhnikovia divaricata, 30-60 parts of processed Aconitum carmichaelii, 100-150 parts of Gentiana macrophylla, 100-150 parts of Morus alba, 120-170 parts of Piper kadsura, and 120-170 parts of Spatholobus suberectus. Formula 2 described above is made from the following ingredients in the specified proportions: Anemarrhena asphodeloides 100-150 parts, Stephania tetrandra 100-150 parts, Lonicera japonica vine 100-150 parts, Scutellaria baicalensis 100-150 parts, Gardenia jasminoides 100-150 parts, Phellodendron chinense 80-100 parts, Smilax glabra 100-150 parts, Paeonia suffruticosa 100-150 parts, Rehmannia glutinosa 100-150 parts, Gypsum fibrosum 60-100 parts, and Trionyx sinensis shell 60-100 parts. Licorice 60-100 parts; Formula 3 is made from the following ingredients in the specified proportions: Prepared Arisaema 50-100 parts, Aconitum carmichaelii 50-100 parts, Prepared Bombyx mori 50-100 parts, Beehive 100-150 parts, Prunus persica 100-150 parts, Carthamus tinctorius 50-100 parts, Drynaria fortunei 100-150 parts, Dipsacus asper 100-150 parts, Natural copper 80-100 parts, Scolopendra subspinipes 20-40 parts, Aconitum carmichaelii Snake 50-100 parts; Formula 4 is made from the following ingredients in the following proportions: Angelica sinensis 100-150 parts, Clematis chinensis 150-200 parts, Atractylodes lancea 100-150 parts, Ligusticum chuanxiong 100-150 parts, Angelica dahurica 100-150 parts, Chaenomeles speciosa 150-200 parts, Gentiana scabra 100-150 parts, Salvia miltiorrhiza 100-150 parts, Coix lacryma-jobi 100-150 parts, Atractylodes macrocephala 100-150 parts.

2. A tablet suitable for rheumatoid arthritis according to claim 1, characterized in that The prescription one is made from the following raw materials in the following proportions: Notopterygium 100-130 parts, Ramulus Cinnamomi 80-100 parts, Angelica pubescens 100-130 parts, Saposhnikovia divaricata 100-130 parts, Radix et Rhizoma Aconiti Preparata 40-50 parts, Gentiana crassicaulis 100-130 parts, Ramulus Mori 100-130 parts, Sinopodophyllum emodi 120-140 parts, Spatholobus suberectus 120-140 parts; the prescription two is made from the following raw materials in the following proportions: Anemarrhena asphodeloides 100-130 parts, Radix et Rhizoma Acanthopanacis 100-130 parts, Lonicera japonica 100-130 parts, Radix Scophulariae 100-120 parts, Fructus Gardeniae 100-130 parts, Phellodendri 80-90 parts, Smilax glabra 100-130 parts, Radix Paeoniae Alba 100-130 parts, Radix Rehmanniae 100-130 parts, Gypsum Fibrosum 60-80 parts, Carapax Trionycis 60-80 parts, Radix Glycyrrhizae 60-80 parts; the prescription three is made from the following raw materials in the following proportions: Radix Anemarrhena 60-80 parts, Rhizoma Typhonii 60-80 parts, Bombyx Batryticatus 60-80 parts, Flos Serpicus 100-120 parts, Semen Persicae 100-120 parts, Carthamus tinctorius 60-80 parts, Drynaria fortunei 100-120 parts, Radix Curculignis 100-120 parts, Natrium 80-90 parts, Mantis religiosa 20-30 parts, Rhabdophis nigrscens 60-80 parts; the prescription four is made from the following raw materials in the following proportions: Radix Angelicae Sinensis 100-120 parts, Radix et Rhizoma Cynanchi 150-180 parts, Radix Atractylodis 100-120 parts, Rhizoma Chuanxiong 100-120 parts, Radix Angelicae Dahuricae 100-120 parts, Chaenomelis 150-180 parts, Radix Gentianae 100-120 parts, Radix Salviae Miltiorrhizae 100-120 parts, Radix Alpiniae Oxyphyllae 100-120 parts, Radix Pini 100-120 parts.

3. A process for the preparation of tablets suitable for rheumatoid arthritis, characterized in that It comprises the following steps: (1) The raw materials of the prescription one, the prescription two, the prescription three and the prescription four are weighed according to the proportioning requirements, are crushed and made into powder, the raw materials of each prescription are mixed uniformly, are sieved, are fumigated and disinfected, four groups of dry powders are obtained, and the dry powders are stored at constant temperature for standby use; (2) The four groups of dry powders obtained in step (1) are mixed uniformly, are sieved, and the filter residue that cannot pass the sieve is removed, so that dry and loose powder with uniform color is obtained; (3) The raw material powder obtained in step (2) is compressed and tableted, so that tablet-shaped medicine tablets are obtained; (4) The tablet-shaped medicine tablets obtained in step (3) are packaged and disinfected, so that finished medicine tablets are obtained.

4. A process for the preparation of a tablet useful in rheumatoid arthritis as claimed in claim 3 wherein In step (1), the four groups of dry powder components are stored at constant temperature at 15-20℃.

5. A process for the preparation of a tablet useful in rheumatoid arthritis as claimed in claim 3 wherein In step (1), the fumigation and disinfection is that 80-120g of mixed fumigation of aconite leaf and mugwort leaf is used for fumigation and disinfection of 1000g of powder for 40-60 minutes, wherein the mixed proportion of the mugwort leaf and the aconite leaf is 80% of the mugwort leaf and 20% of the aconite leaf by weight.

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