12 results about "Flavone II" patented technology

The invention discloses gel with antibacterial and anti-inflammatory effects and a preparation method thereof, and belongs to the technical field of gel for decontamination. The gel is prepared from the following components in parts by weight: 10 to 25 parts of an abelmoschus manihot flavone extract, 10 to 30 parts of an abelmoschus manihot polysaccharide extract, 1 to 3 parts of a gel matrix, 5 to 10 parts of a humectant, 5 to 10 parts of a surfactant and 0.2 to 1 part of a preservative. The flavone and the polysaccharide are separated from the abelmoschus manihot through an ultrasonic-assisted extraction technology, and a stable hydrogel system is formed by combining the flavone and the polysaccharide with a gel matrix. By optimizing the extraction process of the active ingredients of the abelmoschus manihot and combining a gel delivery system, the synergistic antibacterial and anti-inflammatory effects of flavone and polysaccharide are achieved, and the product is stable in performance, high in safety and suitable for clinical and family decontamination scenes.

The invention discloses an intestinal tract hemostatic composition as well as a preparation method and application thereof, and relates to the field of hemostatic drugs. Wherein the catechin, the hyperoside, the isoquercitrin, the quercetin-3-O-glucuronide, the gallocatechin, the myricetin-3-O-galactoside, the proanthocyanidin B1, the proanthocyanidin B3, the syringe-3-O-glucoside and the astragalus smicus glycoside are flavonoid compounds; nuciferine, higenamine, N-methyl-higenamine and N-trans-feruloyl tyramine are taken as alkaloid compounds, and the compound is selected from the group consisting of higenamine, nuciferine, higenamine The composition has the advantages of simple preparation process, good hemostatic effect and the like, and provides a new raw material choice for the development of intestinal bleeding treatment medicines.

This invention discloses a stepwise extraction method and application of flavonoids and lignin from shellfish by-products, relating to the field of agricultural by-product resource utilization technology. The method includes: drying, pulverizing, and ultra-fine pulverizing hawthorn seed shells and / or jujube seed shells to ultra-fine powder with a median particle size D50 of 10-20 μm; extracting with an ethanol aqueous solution at 50-70℃ for 40-80 min under ultrasonic assistance, and separating the solid and liquid to obtain flavonoid extract and residue; drying the residue at 50-70℃ and mixing it with a choline chloride-carboxylic acid eutectic solvent at a solid-liquid ratio of 1:15-1:25 g / mL, stirring at 110-150℃ and 300-500 r / min for 3-7 h; obtaining regenerated lignin by filtration, alcohol washing, and precipitation with water. The method utilizes one-step ultra-fine pulverization to achieve a dual-effect pretreatment that releases flavonoid active substances and moderates lignin extraction conditions.

The application provides a blood-activating and stasis-removing medicinal composition containing fermented douchi and a preparation method thereof, belongs to the technical field of biological medicine, and the medicinal composition comprises fermented douchi, drynaria extract, extract of pereskia aculeata, tanshinone II A, notoginsenoside R1, ligustrazine, rhodioside, total flavones of hawthorn leaves and total flavones of mulberry leaves. The fermented douchi is prepared from soybeans and black beans through fermentation by bacillus subtilis and bacillus coagulans. The drynaria extract is prepared from drynaria powder through common enzymolysis by cellulase, chitinase and beta-glucanase, extraction by a two-phase solvent, and purification by a dextran gel column. The extract of pereskia aculeata is prepared from pereskia aculeata powder through common enzymolysis by pectinase, cellulase and xylanase, common enzymolysis by bromelain and subtilisin, and purification by a macroporous adsorption resin column. The medicinal components are prepared in a specific proportion to relieve blood stasis from two dimensions of "improving blood flow dynamics + preventing thrombus formation".

The invention belongs to the technical field of plant extraction, and particularly relates to a process for optimally extracting a polyphenol-flavone compound from quince seeds through a response surface method. According to the extraction method disclosed by the invention, the quince seeds are subjected to proper treatment, alcohol extraction and ultrasonic treatment, so that total flavonoids and total phenolic acids can be extracted at the same time, the extraction cost is effectively saved, the extraction process is simplified, the extraction efficiency is improved, and the production process is non-toxic, green and environment-friendly.

The invention relates to the technical field of natural product extraction and purification, in particular to a method for extracting flavone and DNJ from mulberry leaves, and the method comprises the following steps: pretreating raw materials, and performing microwave-assisted enzymolysis by using a compound enzyme preparation; performing multi-mode extraction, namely performing two-stage extraction by using a pulse type ultrasonic-counter-current extraction device; gradient separation is carried out, and AB-8 and D101 type resin composite chromatographic column elution is carried out; performing targeted purification, adsorbing and eluting the DNJ through ion exchange resin, and removing impurities from flavone by adopting an ultrafiltration membrane and Zeta potential regulation and control; preparing a finished product, namely performing vacuum concentration and low-temperature spray drying to obtain a high-purity finished product. According to the method, efficient extraction and high-purity preparation of flavone and DNJ are achieved through the steps of finely-controlled raw material pretreatment, multi-mode extraction, gradient separation and purification, finished product preparation, quality monitoring and the like, the extraction process is optimized, the product quality and stability are greatly improved, and the method is suitable for industrial production. Powerful support is provided for comprehensive development and utilization of mulberry leaf resources.

The invention belongs to the technical field of flavone and polysaccharide extraction, and particularly relates to a method for gradient extraction of flavone and polysaccharide from polygonatum sibiricum, which comprises the following steps: (1) drying, rolling and slicing fresh polygonatum sibiricum to obtain polygonatum sibiricum slices; (2) adding deionized water into the polygonatum sibiricum slices, soaking, grinding and collecting polygonatum sibiricum pulp; (3) adding absolute ethyl alcohol into the rhizoma polygonati pulp, carrying out ultrasonic extraction, filtering and separating, and respectively collecting an extracting solution I and filter residues; (4) mixing the filter residues with distilled water, adding a compound enzyme, and uniformly mixing to obtain a mixture; carrying out ultrasonic extraction on the mixture, filtering and separating, and collecting and concentrating supernate to obtain a concentrated solution; (5) adding absolute ethyl alcohol into the concentrated solution, standing, carrying out alcohol precipitation and centrifugal separation, respectively collecting an extracting solution II and a lower-layer precipitate, and freeze-drying the precipitate to obtain polygonatum polysaccharide; and (6) combining the extracting solution I and the extracting solution II, concentrating, and freeze-drying to obtain the polygonatum sibiricum flavone. According to the method, flavone and polysaccharide are extracted from rhizoma polygonati in a gradient manner.

The invention provides a medicine composition containing fermented soya beans and capable of promoting blood circulation to remove blood stasis and a preparation method of the medicine composition, and belongs to the technical field of biological medicines.The medicine composition comprises the fermented soya beans, thelephora ganbajun extract, holboellia latifolia rind extract, tanshinone IIA, notoginsenoside R1, ligustrazine, salidroside, hawthorn leaf total flavonoids and mulberry leaf total flavonoids. The fermented soybeans are prepared by fermenting soybeans and black beans through bacillus subtilis and bacillus coagulans. The thelephora ganbajun Zang extract is prepared by carrying out common enzymolysis on thelephora ganbajun Zang powder through cellulase, chitinase and beta-glucanase, extracting through a two-phase solvent and purifying through a sephadex column. The stauntonia latifolia rind extract is prepared by performing common enzymolysis on stauntonia latifolia rind powder through pectinase, cellulase and xylanase, performing common enzymolysis on stauntonia latifolia rind powder through bromelain and subtilisin and purifying the stauntonia latifolia rind powder through a macroporous adsorption resin column. The medicine components are prepared according to a specific proportion, and blood vessel stasis is relieved from the two dimensions of improving hemodynamic force and preventing thrombosis.

The invention discloses application of scutellaria baicalensis flavone II in preparation of a medicine for reversing drug resistance of a multi-target tyrosine kinase inhibitor to liver cancer, and belongs to the field of medicine. It is found that scutellaria baicalensis flavone II can effectively enhance the sensitivity of multi-target tyrosine kinase inhibitor drug-resistant hepatoma carcinoma cells to different multi-target tyrosine kinase inhibitors and effectively reverse the drug resistance of the multi-target tyrosine kinase inhibitor drug-resistant hepatoma carcinoma cells to different multi-target tyrosine kinase inhibitors. Therefore, the scutellaria baicalensis flavone II has an application prospect of being developed into a medicine for reversing the drug resistance of the multi-target tyrosine kinase inhibitor drug-resistant liver cancer to different multi-target tyrosine kinase inhibitors. The composition of the scutellaria baicalensis flavone II and the multi-target tyrosine kinase inhibitor has the prospect of being developed into the medicine for treating the multi-target tyrosine kinase inhibitor drug-resistant liver cancer.

The invention belongs to the field of medicinal plant development, and particularly relates to an anti-asthma inflammation traditional Chinese medicine extract as well as an extraction method and application thereof. Millettia specisoa champ is used as a raw material, and Millettia specisoa champ total flavonoids and Millettia specisoa champ total The two extracts are subjected to pharmacological experiments, and researches show that the beautiful millettia root extract containing the total flavonoids or the total polysaccharides can remarkably reduce the levels of Th2 inflammatory factors such as IL-4, IL-5, IL-9, IL-13 and GATA-3 in lung tissues, improve the levels of Th1 anti-inflammatory factors such as IFN-gamma, IL-12 and IL-27, regulate the proportion balance of Th1 / Th2 and inhibit airway inflammatory response; in addition, GATA-3 expression can be blocked, Th2 cell activation hyperfunction is inhibited, pathological characteristic change of asthma is relieved, and great development and utilization potential in asthma treatment is achieved.

This invention discloses a loofah extract with antioxidant activity and its preparation method, belonging to the technical field of plant extracts and natural antioxidants. The method uses loofah leaves, loofah peel, or a combination thereof as raw materials. After pretreatment, crushing, and pulping, the materials undergo acidic hypoxia enzyme-inhibiting pretreatment to reduce the activity of polyphenol oxidase and / or peroxidase. Cell wall degrading enzymes are then added for multi-stage enzymatic hydrolysis to release bound polyphenols. Subsequently, an enzyme source with β-glucosidase, β-glucuronidase, and esterase activity is used to perform directional aglycone conversion of the bound polyphenols, converting bound flavonoids and / or bound phenolic acids into free flavonoid aglycones and / or free phenolic acids. Finally, the extract is obtained through alcohol-water extraction, macroporous resin enrichment, microencapsulation, and drying. The extract obtained by this invention has a high proportion of free active ingredients, good antioxidant activity, and good storage stability.

The application discloses a method for extracting flavonoids and polyphenols from basil, which comprises the following steps: immersing basil dry leaf powder in an ethanol aqueous solution, and separating the solid and the liquid to obtain an immersion liquid after the immersion; adding aluminum chloride to the immersion liquid, stirring, and collecting the precipitate after sufficient reaction to obtain polyphenol-aluminum complex and flavonoid-aluminum complex; dissolving the polyphenol-aluminum complex and the flavonoid-aluminum complex in a beta-cyclodextrin aqueous solution, and obtaining a clathrate solution of beta-cyclodextrin clathrated polyphenol-aluminum complex and beta-cyclodextrin clathrated flavonoid-aluminum complex after the reaction; stirring the clathrate solution, adding alkali salt while stirring, maintaining the pH value at 10-12, and making the alkali salt and aluminum ions in the clathrate produce a precipitation reaction; and obtaining beta-cyclodextrin clathrated polyphenol and beta-cyclodextrin clathrated flavonoid extraction products after the reaction and the precipitation. The method can not only remove volatile oil, but also improve the stability and antioxidant activity of the extraction products.