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37 results about "Flavone II" patented technology
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Flavone composition for sobering and liver protection and its use
The present invention discloses a kind of flavone composition with the function of reducing the body damage caused by excessive indigestion of alcohol obviously, and the composition consists of pueraria flavonid and silybum marianum flavone. Research shows that pueraria flavonid and silybum marianum flavone have obvious cooperative effects of resisting oxidation, protecting liver and promoting elimination of alcohol in body. The present invention also discloses the application of the composition in health food and medicine.
Owner:SHANXI PUDE PHARMA CO LTD
Medicinal composition for preventing or/and treating diabetes mellitus and application of medicinal composition
InactiveCN102895342ASynergisticGood synergistic effectMetabolism disorderEndocrine system disorderUse medicationAlkaloid
The invention provides a medicinal composition for preventing or / and treating diabetes mellitus. The medicinal composition is a preparation prepared by raw material medicines, such as radix puerariae and rhizoma coptidis. The invention also provides application of the medicinal composition. Raw material medicines comprising the radix puerariae and the rhizoma coptidis provided by the invention are used to prevent or / and treat type II diabetes mellitus, so that the raw material medicines have effects on synergistic interaction; and furthermore, effective parts in medicinal materials comprising radix puerariae general flavone and rhizoma coptidis total alkaloids are used in proportion, so as to reach a better effect on synergistic interaction, thereby providing a new clinical application choice.
Owner:SOUTHWEST JIAOTONG UNIV
Ginkgo biloba extract medicinal raw material
InactiveCN106727491APharmacological effects are prominentOrganic active ingredientsNervous disorderBilobalidesGinkgolide C
The invention discloses a ginkgo biloba extract medicinal raw material, and belongs to the field of medicines. The ginkgo biloba extract medicinal raw material is prepared from flavone and lactone which are extracted from ginkgo, wherein the flavone is prepared from quercetin, kaempferol and isorhamnetin; the lactone is prepared from bilobalide, ginkgolide A, ginkgolide B and ginkgolide C; a proportion of the flavone to the lactone is 1 to 1. According to the ginkgo biloba extract medicinal raw material disclosed by the invention, the proportion standard of the flavone and the lactone in original ginkgo biloba extract is changed, and an optimal proportion of a medicine for scavenging free radicals and resisting platelete aggregation is determined.
Owner:HEBEI RUNMAO PHARMA CO LTD
Method for synchronously extracting flavone and alkaloid from folium nelumbinis
InactiveCN101366829AHigh purityImprove qualityMetabolism disorderPlant ingredientsPre treatmentAlkaloid
The invention relates to the deep processing field of farm and sideline products, in particular to a method for extracting flavone and alkaloid simultaneously from lotus leaves. The method is characterized in that the fresh lotus leaves are taken as raw materials and are subjected to pretreatment, acid alcoholic solution extraction, light petroleum derosination, hyperfiltration membrane concentration, purified alkaloid enrichment by gelatin highly acid positive ion exchange resin, adsorption and purification of flavone in lotus leaves by chromatography daiamid resin, and the like. Two products of the alkaloid and the flavone are obtained by one-step method. The invention has the advantages that the method is not only applied to the industrial production on large scale but also prepares the products with high purity as well as meets the requirement of the raw material extractive of national class 2 new drugs.
Owner:WUHAN PUZETIAN FOOD
7-carboxy-flavone derivatives preparation method and therapeutic use
InactiveUS6965039B2Good anti-inflammatory effectOrganic active ingredientsAntipyreticAlkaline earth metalHydrogen atom
The invention concerns novel flavone and isoflavone derivatives of formulae (Ia) and (Ib) wherein: X represents a group of formula —COOR, or —PO(OR)2; R represents a hydrogen atom or an alkaline or alkaline-earth metal, or a lower alkyl group; R1 represents a hydroxy group, a lower alkoxy group or an acyloxy group; R2 and R3, identical or different, represent a hydrogen or halogen atom, or a trifluoromethyl group, a trichloromethyl group, a hydroxy group, an alkoxy group or an acyloxy group comprising 1 to 5 carbon atoms, or R2 and R3 can combine to form an alkylene dioxy group. The invention is useful for rheumatic diseases.
Owner:NEGMA LERADS
Rose containing flavone and malvidin, and method for production thereof
InactiveUS20100281575A1TransferasesOther foreign material introduction processesMethyltransferase GeneTorenia
The invention provides a rose characterized by comprising a flavone and malvidin added by a genetic modification method. The flavone and malvidin are typically produced by expression of a transferred flavone synthase gene, pansy flavonoid 3′,5′-hydroxylase gene and anthocyanin methyltransferase gene. The flavone synthase gene is, for example a flavone synthase gene of the family Scrophulariaceae, and specifically it may be the flavone synthase gene of snapdragon of the family Scrophulariaceae, or the flavone synthase gene of torenia of the family Scrophulariaceae. The flavonoid 3′,5′-hydroxylase gene is, for example, the pansy flavonoid 3′,5′-hydroxylase gene. The anthocyanin methyltransferase gene is, for example, the methyltransferase gene of torenia of the family Scrophulariaceae.
Owner:SUNTORY HLDG LTD
Composition with Staphylococcus aureus resisting effect and preparation method and application thereof
ActiveCN111053803ARealize comprehensive utilizationImprove quality and efficiencyAntibacterial agentsSexual disorderBiotechnologyMedicinal herbs
The invention discloses a composition with a Staphylococcus aureus resisting effect. The composition consists of general flavone of sophora flavescens and general flavone of liquorice. The general flavone parts of sophora flavescens and liquorice are prepared through extraction, extraction, enrichment and the like, and are compounded. The results of in-vitro research shows that the composition directly inhibits the growth of gram-positive bacteria such as Staphylococcus aureus and can reduce the formation of biofilms and the content of staphyloxanthin; the results of in-vivo studies prove thatthe composition can obviously reduce mammary gland alveolar hyperplasia and alveolar inflammatory cell infiltration of mice caused by Staphylococcus aureus infections, and significantly reduce the bacterium carrying amount of mouse mammary gland tissues of each model group and the content of IL-1 beta, IL-2 and TNF-alpha inflammatory factors in the mammary gland tissues. According to the invention, the comprehensive utilization of medicinal materials including sophora flavescens and liquorice and the quality and efficiency improvement of the industry can be realized; the waste is turned intothe wealth; and the composition has good economic effects and social benefits, and accords with the sustainable development strategy in China.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Method for separating flavone, saponin and polysaccharide from cyclocarya paliurus by continuous method
PendingCN112870254AEfficient use ofEasy to operatePlant ingredientsActive agentBiochemical engineering
The invention relates to a method for separating flavone, saponin and polysaccharide from cyclocarya paliurus by a continuous method. The method comprises the following steps: enzymolysis, percolation extraction, filtration, decoloration, polyamide adsorption separation of flavone and saponin, and separation and purification of polysaccharide. The enzymolysis is performed under the action of a compound enzyme and an ionic surfactant. The invention provides a brand new method for separating various natural active components from cyclocarya paliurus, the process has strong operability, no acid or alkali is used, toxic, harmful, flammable and explosive chemical solvents are not used, the method is safe, environment-friendly, pollution-free and low in production cost, efficient and comprehensive utilization of cyclocarya paliurus resources is also realized, and the method is suitable for industrial production. The three obtained cyclocarya paliurus active ingredient products are high in yield and content, and the method is a process for remarkably improving the economic value of a cyclocarya paliurus extraction process.
Owner:HUNAN HUACHENG BIOTECH
Separation and purification technology of pineapple peel flavone and flavone
InactiveCN111714570AHigh purityImprove antioxidant capacityAntinoxious agentsPlant ingredientsOrganic chemistryMacroporous resin
The invention belongs to a separation and purification technology of pineapple peel flavone, and particularly relates to a process for separating and purifying the pineapple peel flavone by using macroporous resin adsorption. The process comprises the following steps of degreasing pineapple peels by using a degreasing agent, performing extraction by using ethanol, and purifying obtained flavone crude extraction liquid by using an optimal scheme. According to the process, an optimal separation and purification method is found, and macroporous resin D101 is adopted for separation and purification, so that the flavone with relatively high purity is obtained. The recovery rate of the flavone obtained by separating and purifying the pineapple peels can reach 60.16%, and the purity reaches 86.72%. The antioxidant activity of the purified pineapple peel flavone is higher than that of unpurified flavone and BHT. Therefore, the obtained pineapple flavone product with relatively high purity andstrong oxidation resistance provides a scientific basis for further carrying out pineapple peel flavone industrial production and improving the utilization value of the pineapple peels in the future.
Owner:GUANGZHOU UNIVERSITY
Sansevieria trifasciata Prain flavones, and preparation method and application thereof
InactiveCN105153255AImprove cleanlinessEnhanced inhibitory effectAntibacterial agentsOrganic active ingredientsEscherichia coliSuperoxide
The invention discloses Sansevieria trifasciata Prain flavones which are prepared by the following steps: by using fresh Sansevieria trifasciata Prain as the raw material, pretreating to obtain dry Sansevieria trifasciata Prain powder; carrying out ultrasonic ethanol extraction; extracting with petroleum ether and ethyl acetate; and purifying by silica gel chromatography to obtain the four components TFS-a, TFS-b, TFS-c and TFS-d of the Sansevieria trifasciata Prain flavones. The Sansevieria trifasciata Prain flavones have obvious inhibiting actions on Salmonella and Escherichia coli, and the MIC (minimal inhibitory concentration) is respectively 3.75 mg / mL. The Sansevieria trifasciata Prain flavone TFS-b has obvious removal actions on hydroxy free radicals, DPPH free radicals and superoxide anions (respectively 59.8%, 78.6% and 84.2%). The Sansevieria trifasciata Prain flavones TFS-c and TFS-d have obvious inhibiting actions on growth of human cervical cancer cell line Hela and mouse myeloma cell line SP2 / 0, and do not have significant difference for growth of human lung cancer cell line A549, laryngocarcinoma cell line Hep-2 and normal cell line DK.
Owner:JILIN AGRICULTURAL UNIV
Soothing and desensitization composition and application thereof
PendingCN113440461AReduce sensitivityReduce transdermal water lossCosmetic preparationsToilet preparationsActive agentAlkaloid
The invention discloses a soothing and desensitization composition and application thereof, and belongs to the technical field of skin care products. The soothing and desensitization composition is prepared from the following components in parts by weight: 0.1 to 5 parts of saffron crocus extract; 0.1-5 parts of a radix ophiopogonis root extract; 0.1-5 parts of a radix sophorae flavescentis extract; and 0.1 to 10 parts of D-panthenol. Carbonylation modified flavone and polysaccharide substances in the saffron crocus extract in the soothing and desensitization composition have good anti-free radical activity and anti-inflammatory activity, steroidal saponin in the radix ophiopogonis root extract can well inhibit histamine, THF-alpha, IL-6 and metal matrix protease, anti-inflammation can be well achieved, skin stress reaction can be well reduced. Alkaloid and flavonoid compounds in the radix sophorae flavescentis extract can inhibit vasodilatation and activate body immunocompetence, and by combining with D-panthenol with a moisturizing effect, a synergistic effect is achieved, stimulation brought by a surfactant SLS, a retinol derivative and the like can be effectively relieved, a damaged barrier can be repaired, and the sensitive degree of sensitive skin can be reduced.
Owner:DOCTOR PLANT GUANGDONG BIOTECHNOLOGY CO LTD
Antilipemic and antioxidant activities of different extracts of hemiptelea and application in medicine
The invention discloses a preparation method of hemiptelea general flavone and water extract, and discloses the following two activities: (1) the hemiptelea general flavone and the water extract have prevention and treatment functions to the hyperlipidaemia, and have functions of reducing the serum total cholesterol (TC) content and reducing the low-density lipoprotein cholesterol (LDL-C) content along with the prolonging of the drug dispensing time; and (2) the hemiptelea general flavones has functions of anti-oxidizing and eliminating hydroxyl radical. The invention is not only suitable for developing the new drugs and functional health care products for preventing and treating the aging, heart cerebrovascular disease, atherosclerosis, inflammation and diseases closely related to the radical, but also suitable for developing the new drugs and functional health care products for preventing and treating the hyperlipidaemia.
Owner:包海鹰
Method for jointly extracting flavone and pectin from passion fruit peel
PendingCN113425754AHigh dissolution rateReduce oxidationCosmetic preparationsOrganic active ingredientsBiotechnologyCellulase
The invention discloses a method for jointly extracting flavone and pectin from passion fruit peel. The method comprises the following steps: cleaning, drying and crushing to obtain passion fruit peel powder; adding passion fruit peel powder into an extraction tank, adding ethanol, solubilizer triethanolamine and dimethyl carbonate, adjusting the pH value to 8.0-8.5 by using alkali, carrying out ultrasonic extraction, filtering, and separating filtrate A and filter residue A; passing the filtrate A through a column, and performing reduced pressure distillation to obtain passion fruit peel total flavonoids; taking the filter residue A, inactivating enzyme, adding water, Tween-80 and cellulase, soaking, carrying out ultrasonic extraction for 5-15 minutes, filtering, and separating filtrate B and filter residue B; and concentrating the filtrate B under reduced pressure, decolorizing, carrying out alcohol precipitation, filtering, taking a precipitate, and drying the precipitate to obtain the pectin. According to the method of the invention, the flavone and the pectin can be jointly extracted from the passion fruit peel, and comprehensive utilization of the passion fruit peel is realized.
Owner:GUANGXI NORMAL UNIV FOR NATITIES
Scutellariae radix flavone methoxytransferase gene, and recombinant vector and application thereof
The invention provides a scutellariae radix flavone methoxytransferase gene, and a recombinant vector and application thereof. The scutellariae radix flavone methoxytransferase gene comprises at least one of SbFOMT3, SbFOMT5 and SbFOMT6 genes, wherein the sequence of the SbFOMT3 gene is as shown in SEQ ID No.1, the sequence of the SbFOMT5 gene is as shown in SEQ ID No.3, and the sequence of the SbFOMT6 gene is as shown in SEQ ID No.5. According to the invention, three genes of SbFOMT3, SbFOMT5 and SbFOMT6, which are coded to participate in a methylation synthesis route of oroxylin, 7-methoxy baicalein and flavones with similar structures, are cloned from a labiatae scutellariae medicinal plant scutellariae radix for the first time, and are gene sequences derived from flavones 7-site and 6-site oxygen methyltransferase of the scutellariae radix. Enzyme encoded by the genes can participate in biosynthesis of the oroxylin and the 7-methoxy baicalein and catalyze the oxygen methylation reaction of flavonoid substances with similar structures, scutellariae radix flavone I and baicalein I can be synthesized under the synergistic effect of PFOMT, and a basis is provided for production of effective active substances.
Owner:SHANGHAI CHENSHAN BOTANICAL GARDEN
Use of flavonoids from marine fungi
ActiveCN111728964AProtection from oxidative stressFree from damageOrganic active ingredientsAntinoxious agentsBiotechnologyDisease
The invention discloses use of flavonoids from marine fungi, specifically use of two flavonoids extracted from marine microorganisms, 2, 3, 4, 6, 8-pentahydroxy-1-methylxanthon and chromone arthone, as activators of Nrf2 in the treatment of cardiovascular and cerebrovascular diseases. The flavonoids are extracted from metabolites of deep-sea fungi. Through research of the invention, it is found that 2, 3, 4, 6, 8-pentahydroxy-1-methylxanthon and chromone arthone can reduce the expression of reactive oxygen species (ROS) in cells by activating Nrf2, protect endothelial cells from oxidative stress and damage, and play a role in antioxidant protection of endothelial cells. The invention provides support for researching 2, 3, 4, 6, 8-pentahydroxy-1-methylxanthon and chromone arthone as activators of Nrf2 to treat cardiovascular and cerebrovascular diseases.
Owner:UNIV OF JINAN
A kind of Cyclocarya paliurus extract and its application in the preparation of anti-coronavirus medicine
ActiveCN112675211BGood preparation safetyInhibition of lesionsAntiviralsPlant ingredientsBiotechnologyCytopathic effect
The invention discloses an extract of Cyclocarya paliurus and its use in preparing anti-coronavirus medicines. In the Cyclocarya paliurus extract, the content of flavonoids is 20wt.%-40wt.%, the content of polysaccharides is 5wt.%-20wt.%, and the content ratio of flavones and polysaccharides is ≥1.5:1. Experimental results show that the Cyclocarya paliurus extract with specific flavonoid and polysaccharide content of the present invention has SARS-CoV-2 virus neutralizing activity, can effectively inhibit the cytopathy caused by SARS-CoV-2 virus, and protect cells from being infected by SARS-CoV-2. 2 virus infection. The Cyclocarya paliurus extract provided by the invention has broad application prospects in the preparation of anti-coronavirus (especially SARS-CoV-2 virus) drugs with good safety and low preparation cost.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV +1
Anti-coccidiosis feed additive as well as preparation method and application thereof
InactiveCN113974012AMaintain healthIncrease growth rateFood processingAnimal feeding stuffBiotechnologyCoccidiosis
The invention belongs to the technical field of feed additives, and discloses an anti-coccidiosis feed additive as well as a preparation method and application thereof, and the additive comprises the following components: halofuginone, callicarpa nudiflora and gynostemma pentaphylla, further comprises radix bupleuri and astragalus polysaccharide. The halofuginone has an excellent coccidiosis killing effect, the callicarpa nudiflora is added to be compatible with the halofuginone, main components of the callicarpa nudiflora comprise flavone and part of terpenoids, and the callicarpa nudiflora has the repairing and intestinal health maintaining effects of stopping bleeding, diminishing inflammation, astringing and the like; gynostemma pentaphylla is added, so that not only nutritional substanes can be provided, but also the effect of improving immunity and treating enteritis is achieved; through compatibility of the three components, the occurrence probability of enteritis caused by coccidiosis can be reduced, and the growth speed and the survival rate of chickens are increased.
Owner:江门市旺海饲料实业有限公司
7-carboxy-flavone derivatives, preparation method and therapeutic use
Owner:NEGMA LERADS
Fish gelatin hydrolysate with oral hypoglycemic activity and application thereof
PendingCN113528604AReduce usageReduce pollutionHydrolysed protein ingredientsMetabolism disorderBiotechnologyNeutral protease
The invention discloses a fish gelatin hydrolysate with oral hypoglycemic activity and an application thereof, and the fish gelatin hydrolysate is mainly prepared by the following method: 1) mixing fish gelatin with papain and neutral protease, adding phellinus linteus ketone and alpha-naphthoflavone at the same time, and performing enzymolysis to form a fish gelatin product A; and 2) mixing the fish gelatin product A with alkaline protease and pepsase, adding herba lycopi flavone and scutellaria baicalensis flavone I at the same time, and continuing enzymolysis to form a fish gelatin final product. Compared with the prior art, the invention provides a novel fish gelatin hydrolysate which has a remarkable oral hypoglycemic effect and can be used for preparing health-care food. Besides, the preparation method is simple and easy to operate, the activity of hydrolase is remarkably promoted by utilizing flavone, the use amount of food-grade hydrolase is remarkably reduced, the hydrolysis reaction time is remarkably shortened, and the production cost is greatly reduced.
Owner:镇江市天益生物科技有限公司
Flavone synthase I/flavanone-3-hydroxylase and application thereof in field of flavonoid compound synthesis
The invention relates to a flavone synthase I / flavanone-3-hydroxylase and application of the flavone synthase I / flavanone-3-hydroxylase in the field of flavonoid compound synthesis. The invention discloses flavone synthase I / flavanone-3-hydroxylase of psidium caudatum. The amino acid sequence of the flavone synthase I / flavanone-3-hydroxylase of the psidium caudatum is as shown in SEQ ID No. 1. According to the invention, a bifunctional enzyme capable of introducing a double bond between a flavanone C2 site and a flavanone C3 site or introducing a hydroxyl group at the flavanone C3 site is cloned and identified from ferns for the first time. The gene has relatively high catalytic activity on common flavanone compounds, and a candidate gene is provided for producing the flavanone compounds. The PnFNS I / F3H can be used for synthesizing flavones and flavanonol in escherichia coli, and the contents of plant flavones and flavanonol compounds in transgenic arabidopsis thaliana are increased at the same time. The gene can be used for producing flavone and flavonol compounds in escherichia coli and plant chassis, and has high application value.
Owner:SHANDONG UNIV
Combined preparation containing flavone and immunomodulatory peptides, and preparation method and application thereof
ActiveCN111317822AImprove immunityOvercoming Enzyme BarriersOrganic active ingredientsHeavy metal active ingredientsInfectious DisorderRegulatory peptide
The invention relates to a combined preparation containing flavone and immunomodulatory peptides, and a preparation method and application thereof. The combined preparation contains the following components: (1) a natural flavonoid compound; (2) metal ions; and (3) immunomodulatory peptides. The combined preparation can improve the stability and bioavailability of the natural flavonoid compound and immunomodulatory peptides, and when applied to mammals, the combined preparation can synergistically enhance immune response and play a role in improving the immunity of the organism. The combined preparation is applied to low-immunity people and prevention and control of viral and bacterial infectious diseases, accords with the national guidance direction of the large health industry, and has positive significance and broad prospects for strategic measures of preventive treatment of diseases.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
Application of V 'RG-I in cosmetics
PendingCN111920705AVulnerableAccelerated destructionAntibacterial agentsCosmetic preparationsBiologyBlood vessel
The invention discloses an application of V 'RG-I in cosmetics, the V' RG-I is a compound of branched pectin citrus flavones and vitamins extracted from citrus fruits, and the V 'RG-I is applied to cosmetics smeared on skin. The V 'RG-I has the following beneficial effects: good moisture absorption and moisture retention effects are achieved; a good toxin expelling effect is achieved; the effectsof preventing acne, chloasma and the like are achieved; a good anti-aging function is achieved; a good blood vessel beautifying effect is achieved; the beverage has a good effect of regulating blood pressure and blood fat, and can effectively prevent the generation of chloasma; a good skin tissue repairing function is achieved; a good whitening effect is achieved; the acne-removing facial mask hasa good bacteriostatic effect and a good acne-removing effect; the skin injury can be well repaired; a good protection mechanism for skin light damage is achieved; a good antioxidant mechanism is achieved; a mechanism for reducing DNA damage is provided; the normal synthesis and degradation of the skin extracellular matrix can be maintained.
Owner:钟卫倩
Cyclocarya paliurus extract and application thereof in preparation of anti-coronavirus drugs
ActiveCN112675211AGood preparation safetyInhibition of lesionsAntiviralsPlant ingredientsBiotechnologyPharmaceutical drug
The invention discloses a cyclocarya paliurus extract and application thereof in preparation of anti-coronavirus drugs. In the cyclocarya paliurus extract, the content of flavone is 20wt.%-40wt.%, the content of polysaccharide is 5wt.%-20wt.%, and the content ratio of the flavone to the polysaccharide is greater than or equal to 1.5: 1. Experimental results show that the cyclocarya paliurus extract with the specific flavone and polysaccharide content has SARS-CoV-2 virus neutralizing activity, can effectively inhibit cytopathy caused by the SARS-CoV-2 virus, and protects cells from being infected by the SARS-CoV-2 virus. The cyclocarya paliurus extract provided by the invention has a wide application prospect in preparation of anti-coronavirus (especially SARS-CoV-2 virus) medicines with good safety and low preparation cost.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV +1
Special premixed feed for laying sheldrakes in egg producing period
PendingCN111602747APromote absorptionIncrease profitAnimal feeding stuffAccessory food factorsBiotechnologyYolk
The invention discloses a special premixed feed for laying shelducks in an egg producing period. The feed comprises stone powder, calcium hydrophosphate, selenium yeast, yiduoli enzyme complex, bakingsoda, choline chloride, sodium chloride, methionine, customized multi-minerals, customized multi-vitamins, Yihebao, betaine, phytase, lipoic acid, bile acid, tea polyphenol and prinsepia utilis royle. The bile acid added in the invention promotes the absorption of lipids and other nutrients in the feed, and improves the feed utilization rate and the feed energy level. The tea polyphenol improvesthe taste of egg white, so that the protein gel is loose and porous in structure and is brighter. And the lipoic acid improves the quality of egg white and yolk by utilizing the strong oxidation resistance of the lipoic acid. The added prinsepia utilis royle contains flavone and polysaccharide, and the immunity and oxidation resistance of the sheldrakes are improved through intake of the flavone;the polysaccharide has the effects of promoting bifidobacterium proliferation, inhibiting pathogenic bacteria, preventing constipation and abdominal distension, promoting digestion and regulating intestines and stomach, so that the absorption and utilization rate of the feed is improved.
Owner:江苏中煤长江生物科技有限公司
Solid dispersion (SD) of radix salviae miltiorrhizae and radix puerariae extracts and preparation method of SD
ActiveCN112315997AHigh dissolution rateGood control effectPowder deliveryNervous disorderPuerariae Radix extractTanshinone IIA
The invention discloses a solid dispersion (SD) of radix salviae miltiorrhizae and radix puerariae extracts and a preparation method of the SD. The SD takes total salvianolic acid, total flavonoids ofradix puerariae and total tanshinone as effective medicinal components, takes the contained total salvianolic acid and total flavonoids of radix puerariae as a combined carrier of the total tanshinone, and does not contain other solid dispersion carrier materials except the total salvianolic acid and the total flavonoids of radix puerariae. When the SD is prepared, the total salvianolic acid andthe total flavonoids of radix puerariae are mixed and concentrated into the combined carrier, and then the total tanshinone is loaded, and concentration and drying are carried out to form the SD. Thedissolution rate of tanshinone is effectively improved, and the 90 min cumulative dissolution rate of tanshinone IIA in the total tanshinone is larger than 60%.
Owner:SICHUAN ACAD OF CHINESE MEDICINE SCI
Uses of flavonoids of marine fungal origin
ActiveCN111728964BProtection from oxidative stressFree from damageOrganic active ingredientsAntinoxious agentsDiseaseMetabolite
Owner:UNIV OF JINAN
A method for detecting the content of various flavonoids in yew branches and its preparation method
ActiveCN108627596BSimple methodGood repeatabilityComponent separationAmentotaxus argotaeniaGradient elution
The invention discloses a method for detecting the contents of various flavonoids in yew branches. The detection method is for detecting the contents of rutin, quercetin, amiflavones of spiky chinensis, isoflavones of ginkgo biloba and biflavones of golden pine, including Following steps: the preparation of need testing solution; The preparation of reference substance solution; High-performance liquid chromatography is measured, need testing solution and reference substance solution are injected into high-performance liquid chromatograph detection respectively, and chromatographic condition is as follows: Use C18 as chromatographic column , with methanol-water mixed solution as the mobile phase, gradient elution, detection wavelength 330nm, flow rate 1.0mL / min, column temperature 30°C, and the number of theoretical plates not less than 3000. The present invention adopts high-performance liquid chromatography to simultaneously detect the contents of rutin, quercetin, biflavonoids, biflavones of isoginkgo biloba and biflavones of golden pine in yew branches. It is convenient and quick to determine the contents of five flavonoids in the branches and leaves of Taxus chinensis.
Owner:HUBEI XIANGRUIFENG ECOLOGICAL FRUIT IND CO LTD
Combined extraction method of total flavonoids and total alkaloids from Qingpi and its application
Owner:SHANGHAI JAKA BIOTECH CO LTD
Xinhui citrus fermentation liquor as well as preparation method and application thereof
ActiveCN111500643ALow in ethanolTotal flavonoids highCosmetic preparationsMicroorganismsBiotechnologyMicrobiology
The invention relates to the technical field of microbial fermentation, and discloses Xinhui citrus fermentation liquor as well as a preparation method and application thereof. The Xinhui citrus fermentation liquor is obtained by fermenting Xinhui citrus with lactobacillus plantarum Picp-2 with the preservation number of CCTCC No: M 20191045 and saccharomyces cerevisiae ZLG-6 with the preservationnumber of CCTCC No: M 20191046. According to the invention, specially screened saccharomyces cerevisiae and lactobacillus plantarum are selected as dominant strains for Xinhui citrus fermentation andare mainly used for fermentation preparation of total flavonoids and lactic acid. The prepared Xinhui citrus fermentation liquor has relatively high total flavone and lactic acid components and relatively low ethanol content; compared with other citrus pulp, the content of total flavonoids of the Xinhui citrus pulp can be increased by over 40%, the content of lactic acid can be increased by over1200%; the Xinhui citrus fermentation liquor can be used as an effective component of cosmetics or food, and the problem that a large amount of Xinhui citrus pulp is wasted can be effectively solved.
Owner:INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI +1
Preparation method of hawthorn leaf aqueous extract
InactiveCN111991455ASeparability in timeTimely purificationSenses disorderNervous disorderBiotechnologyPropanol
The invention discloses a preparation method of a hawthorn leaf aqueous extract, and belongs to the field of traditional Chinese medicine and pharmacy. A hawthorn extract comprises flavone and polysaccharide. The preparation method comprises the following steps of crushing hawthorn leaves, adding water, adding ionic liquid, blowing air into mixed liquor, at the same time, performing ultrasonic / microwave cooperative treatment, separating foams from the mixed liquor, then performing centrifugal separation on the mixed liquor after foam removal, taking supernatant, and performing concentration toobtain a primary extracting solution; adding a propanol-ammonium sulfate biphase system to the primary extracting solution, wherein the propanol-ammonium sulfate biphase system comprises a propanol top phase and an ammonium sulfate bottom phase, performing stirring to enable flavone in the hawthorn aqueous extract to enter the propanol top phase and polysaccharide in the hawthorn aqueous extractto enter the ammonium sulfate bottom phase, performing standing, and performing separation on the two phases; and step III, respectively performing extracting on a propanol phase containing flavone and an ammonium sulfate phase containing polysaccharide so as to obtain the flavone and the polysaccharide. The hawthorn leaf aqueous extract disclosed by the invention is high in contents of the flavone and the polysaccharide.
Owner:江西纳弗堂制药有限公司
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