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Bisoprolol-containing adhesive patch and packaging body therefor

A bisoprolol and patch technology, which is applied in the field of patches containing bisoprolol, can solve the problems of difficulty in taking out the patch, reduced release liner peelability, etc., and achieves easy removal, reduced contact area, and reduced adhesion area. Effect

Inactive Publication Date: 2016-04-20
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, when the adhesive layer contains a plasticizer, a tackifier, a liquid component, etc., this tendency becomes remarkable, so there is a problem that these substances ooze out from the end surface of the adhesive layer, and Attached (detoured) to the back of the support or release liner, or even to the inner surface of the packaging material, as a result, the patch containing bisoprolol in the form of a sheet sticks to the inner surface of the packaging material, and it is difficult to remove the bisoprolol-containing patch. Er's patch
[0007] However, although the removal property from the package is improved by the high peeling force, the peeling property of the release liner at the time of use may be reduced.

Method used

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  • Bisoprolol-containing adhesive patch and packaging body therefor
  • Bisoprolol-containing adhesive patch and packaging body therefor
  • Bisoprolol-containing adhesive patch and packaging body therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3 and comparative example 1

[0104] 13.72 parts of high molecular weight polyisobutylene (viscosity average molecular weight = 4,000,000), 27.44 parts of medium molecular weight polyisobutylene (viscosity average molecular weight = 55,000), 27.44 parts of alicyclic saturated hydrocarbon resin (tackifier), isopropyl myristate ( 30.00 parts of organic liquid components) and 1.40 parts of bisoprolol (free body) were mixed in toluene to prepare a viscous toluene solution of the adhesive composition. The obtained solution was coated on various polyethylene terephthalate (PET) release liners (thickness: 75 μm) described in Table 1 so that the thickness after drying was 200 μm, and it was dried in hot air. Dry at 100° C. for 5 minutes in a circulating dryer to form an adhesive layer. The pressure-sensitive adhesive layer was bonded to a PET film (thickness 2 μm) and a PET nonwoven fabric (weight per unit area = 12 g / m 2 ) on the non-woven fabric side of the support of the laminated film, pressurize the peripher...

experiment example

[0107] (1) Peeling force

[0108] Each of the bisoprolol-containing patches of Examples 1 to 3 and Comparative Example 1 was cut into strips with a width of 24 mm, and each was used as a sample. One end of each sample was peeled off, and a release liner and an adhesive sheet were fixed on one chuck of a tensile testing machine (small benchtop testing machine EZTestEZ-S, manufactured by Shimadzu Corporation), and the Under the conditions of 23±2°C and 50±10% R.H., peel and measure along the direction of 180 degrees at a speed of 300mm / min. The measurement results are shown in Table 1 together.

[0109] (2) Removal

[0110] The packs of the bisoprolol-containing patches of Examples 1 to 3 and Comparative Example 1 were opened by expert panelists, and the ease of taking out the patches from the packages was evaluated. The above evaluation was carried out 5 times, and the cases where all were evaluated as easy to take out were set as "○", the cases where not all but several tim...

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Abstract

The present invention relates to a bisoprolol-containing adhesive patch that is provided with: an adhesive patch body that comprises a support body and an adhesive layer that contains bisoprolol and that is formed on one surface of the support body; and a peeling liner that is temporarily attached to the adhesive surface of the adhesive layer of the adhesive patch body. The peel force between the adhesive layer and the peeling liner is equal to or less than 0.07 N / 24 mm width. This bisoprolol-containing adhesive patch minimizes the adhesion thereof to the inner surface of a packaging material, can be extracted with extreme ease at the time of use, and has good peeling liner peelability at the time of use.

Description

technical field [0001] The present invention relates to patches containing bisoprolol. In addition, the present invention relates to a packaging body of a bisoprolol-containing patch having excellent handleability, which is obtained by packaging the bisoprolol-containing patch with a packaging material. Background technique [0002] In recent years, as means for administering drugs into the living body, patches in which a drug-containing adhesive sheet is attached to the skin have been used. In such a patch, an adhesive layer containing a transdermally absorbable drug is laminated on one side of a plastic support such as polyester or polyethylene, and the exposed surface of the adhesive layer is covered with a release liner. . Usually, such a patch is individually packaged in a water-impermeable packaging material in order to prevent volatilization of the contained transdermally absorbable drug and to prevent the influence of humidity. [0003] Bisoprolol, a highly select...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61K9/70A61K47/32A61K47/34A61P9/06A61P9/10A61P9/12
CPCA61K9/7053A61K31/138A61P9/06A61P9/10A61P9/12
Inventor 青柳和宏雨山智石仓准漆原直子立川悠中村哲也
Owner NITTO DENKO CORP
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