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Bisoprolol-containing patch preparation

A bisoprolol and patch technology, which is applied in the field of bisoprolol-containing patches, can solve the problems of adhesive fixation (reduced adhesion of sweat-resistant adhesive, reduced skin adhesive force, easy roll-up of peripheral parts, etc.) To achieve excellent skin adhesiveness, skin irritation reduction effect

Inactive Publication Date: 2016-04-27
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the transdermal absorption preparation obtained by laminating the above-mentioned gel-like pressure-sensitive adhesive layer on the support body may have reduced adhesive fixability (sweat-resistant adhesiveness) to the skin surface in summer when sweating is severe. The skin adhesion of the peripheral part of the percutaneous absorption preparation is reduced, and the peripheral part is sometimes easy to roll up

Method used

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  • Bisoprolol-containing patch preparation
  • Bisoprolol-containing patch preparation
  • Bisoprolol-containing patch preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～8、 comparative example 1～8

[0094] A viscous toluene solution of the adhesive composition was prepared according to the compounding ratio described in Table 1, and the obtained solution was coated on a poly(ethylene terephthalate) (PET) substrate that had been subjected to a silicone release treatment. A liner (thickness: 75 μm) was made to have a dry thickness as described in Table 2, and it was dried in a hot air circulation dryer at 100° C. for 5 minutes to form an adhesive layer. The adhesive layer was bonded to a PET film with a thickness of 2 μm and a 12 g / m 2 The nonwoven fabric side of the PET nonwoven fabric laminated film was obtained to obtain a sheet-shaped patch. Table 2 shows the results of measuring the stress relaxation rate and shear stress of the obtained patches by the method described above. In addition, the compounding ratio of each component described in Table 1 is the ratio (weight%) with respect to the whole adhesive composition.

[0095] [Table 1]

[0096]

[0097] [Table 2...

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Abstract

The present invention pertains to a bisoprolol-containing patch preparation containing a support body and an adhesive layer laminated to one surface of the support body and containing an adhesive agent and free bisoprolol, the stress relaxation percentage of the adhesive layer being 20-90%, and the shear stress of the adhesive layer being 1.0-6.5 N / 30 mm width. The bisoprolol-containing patch preparation has suppressed peeling during use, has superior skin adhesiveness, and suppresses skin irritation during delamination. As the adhesive agent, a rubber-based adhesive is preferable, and a polyisobutylene and / or styrene-isoprene-styrene block copolymer is more preferable.

Description

technical field [0001] The present invention relates to a bisoprolol-containing patch for sustainably absorbing bisoprolol into a living body through a skin surface. Background technique [0002] Bisoprolol, which is a highly selective antagonist of β1 receptors of sympathetic nerves, is used to improve essential hypertension, angina pectoris, arrhythmia, etc., and its fumarate is orally administered in the form of tablets. On the other hand, in the case of oral administration, there are disadvantages such as poor persistence of pharmacological effects, rapid fluctuations in blood drug concentration after administration, and easy side effects. In order to improve the above problems, transdermal preparations have attracted attention in recent years. . [0003] Such transdermal preparations can avoid, for example, drug metabolism and various side effects caused by the first pass through the liver, and can allow the drug to be administered continuously for a long period of tim...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61K9/70A61K47/32A61P9/06A61P9/10A61P9/12
CPCA61K9/7053A61K31/138A61P9/06A61P9/10A61P9/12A61P25/02A61K47/14
Inventor 井上祥孝石仓准青柳和宏雨山智田中智也立川悠中村哲也南邦弘汤浅修一朗
Owner NITTO DENKO CORP
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