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Adhesive patch containing bisoprolol

A bisoprolol and patch technology, applied in the field of percutaneous absorption type patches, can solve problems such as undescribed exudation, unresearched patch shape, etc., and achieve the effects of inhibiting content drop, sufficient adhesive strength, and reducing friction

Inactive Publication Date: 2012-11-07
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent document does not describe anything related to the exudation of bisoprolol or its salt in the packaging bag, and the stability, handling and adhesiveness of the patch related to the cold flow of the adhesive layer components any situation related to the effect of , and among them the situation related to the shape of the patch used to solve the problem was not studied

Method used

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  • Adhesive patch containing bisoprolol
  • Adhesive patch containing bisoprolol
  • Adhesive patch containing bisoprolol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] The adhesive sheet A was set on a press base with a surface temperature of 30°C. Use a heated rectangular stamper (external size 64mm×64mm, the radius of the corner arc part (hereinafter referred to as "R") is 8mm, the inner size is 56mm×56mm, R is 4mm, made of iron Manufacture), heating the surface of the support of the adhesive sheet A under pressure so that the back part of the release liner is near the center of the patch (heating temperature: 150°C, compression molding pressure: 2×10 7 N / m 2 , Heating and pressing time: 0.3 seconds). In such a manner that the heated and pressurized area corresponds to the peripheral portion of the patch obtained later, the patch body and the glass spacer are simultaneously punched out from the heated and pressurized adhesive sheet A using a press knife. Show its schematic plan in figure 1 in. will figure 1 The cross-sections cut along the line I-I and line II-II are shown in figure 2 (a) and (b).

[0110] From figure 1 with figure...

Embodiment 2

[0112] The patch was manufactured in the same manner as in Example 1, except that the conditions of heating and pressing were changed to: heating temperature: 120°C, compression mold pressure: 2×10 7 N / m 2 , Heating and pressing time: 1 second. The shape of the obtained patch and the figure 1 with 2 The shape and the like of the patch of Example 1 shown in are the same.

Embodiment 3

[0114] The patch was manufactured in the same manner as in Example 1, except that the conditions of heating and pressing were changed to: heating temperature: 100°C, compression molding pressure: 2×10 7 N / m 2 , Heating and pressing time: 0.3 seconds. The schematic plan view of the obtained patch is shown in image 3 Middle; the cross section cut along line I-I and line II-II is shown in Figure 4 (a) and (b). From image 3 with Figure 4 Obviously, the shape and the like of the patch of this embodiment are the same as those of the patch of Example 1, but the difference is that the former does not have a band-shaped connecting bulge (3) between adjacent protrusions (3). 4).

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Abstract

Disclosed is an adhesive patch which effectively inhibits the occurrence of oozing or squeezing out of the adhesive layer component from the exposed area of the adhesive layer of the adhesive patch during storage, and also inhibits the occurrence of oozing of bisoprolol or salts of same from the adhesive layer thereby preventing reduction of drug content. A backing material, a release liner and an adhesive layer respectively, along with the entire adhesive patch, are shaped into a planar rectangle wherein the corners of the adhesive patch are formed into convex shapes on the rear surface on the backing material side. Further, the adhesive patch has a central part and edges wherein the corners of the rectangular shape of the central part can also be formed into convex shapes, and furthermore it can be provided with built-up articulated sections between two or more adjacent convex parts wherein the thickness of the adhesive patch is thinner than the thickness of the adhesive layer at each convex part. If the release liner is provided with a split at the back, the split should not traverse the convex parts.

Description

Technical field [0001] The present invention relates to a transdermal absorption patch, which is suitable for continuous administration of bisoprolol or its salt into the body via the skin surface. Background technique [0002] Bisoprolol is a highly selective antagonist of the β1 receptor of the sympathetic nerve and is used to improve essential hypertension, angina pectoris, and arrhythmia. For oral administration, its fumarate is administered as a tablet. [0003] On the other hand, in pharmaceutical preparations for treating or preventing diseases by administering drugs to the living body, transdermal preparations can avoid, for example, the first drug metabolism in the liver and various side effects, and can also achieve long-term persistence. Administration. Among them, since it facilitates administration and can strictly control the dosage, a patch containing a drug in an adhesive has been actively developed. Under such circumstances, in recent years, various transdermal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/138A61F13/02A61K9/70A61P9/00A61P9/06A61P9/12
CPCA61F2013/00646A61F13/02A61K9/703A61K31/138A61K9/7053A61F13/0253A61F13/0259A61P9/00A61P9/06A61P9/10A61P9/12
Inventor 岩男美宏松冈贤介青柳和宏播摩润今野昌克
Owner NITTO DENKO CORP
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