Adhesive medicament preparation containing bisoprolol

A technology for bisoprolol and pharmaceutical preparations, applied in the field of adhesive pharmaceutical preparations, can solve the problems of difficult drug stability and skin irritation, and achieve the effects of low irritation and good adhesion

Inactive Publication Date: 2008-09-10
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Adhesive medicament preparation containing bisoprolol
  • Adhesive medicament preparation containing bisoprolol

Examples

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Embodiment 1 to 9 and comparative example 1 to 3

[0094] The toluene viscous solution of the composition for forming the adhesive layer was prepared according to the ratio shown in Table 1, and applied to the polyethylene terephthalate (PET) that has been subjected to silicone peeling treatment thereon On the liner (75 μm thick), the thickness after drying becomes 80 μm. It was dried in a hot air circulation type drying oven at 100°C for 5 minutes to produce an adhesive layer. The adhesive layer and the laminated film are glued together to produce an adhesive formulation in the form of a thin layer. The laminated film is composed of a 2 μm thick PET film and a 12 g / m layer on the side of the non-woven fabric. 2 Made of PET non-woven fabric. The PET liner on the laminated thin layer is peeled to expose the adhesive surface, and one or two adhesive layers with the same composition and thickness as above are laminated on the adhesive surface to produce an adhesive layer of 160 μm or 240 μm Thick adhesive formulation. The proportion ...

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Abstract

It is intended to provide an adhesive preparation which has a low irritation to the skin surface, is excellent in stability of bisoprolol in the preparation and further is capable of continuously administrating a pharmacologically effective amount of bisoprolol to the living body. The adhesive preparation 10 has a support 1 and an adhesive layer 2 which is layered on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, a tackifier and an organic liquid component which is compatible with polyisobutylene and the tackifier. By this, the adhesive preparation having good skin adhesiveness, low skin irritation and reduced pain or adhesive residue at the time of removal from the skin surface can be provided. Further, the adhesive preparation in which the stability of bisoprolol in the adhesive preparation is excellent and the pharmacologically effective amount of bisoprolol can be continuously administrated to the living body through the skin surface is provided.

Description

Technical field [0001] The present invention relates to an adhesive pharmaceutical preparation containing bisoprolol for continuous absorption of bisoprolol into the body through the skin surface. Background technique [0002] Bisoprolol has been used to improve essential hypertension, angina pectoris and arrhythmia. The bisoprolol is a highly selective beta in sympathetic nerves. 1 -Receptor antagonist, and its fumarate has been used as a tablet for oral administration. [0003] On the other hand, as a pharmaceutical preparation for treating or preventing diseases by administering a living body drug, a transdermal absorption preparation has received great attention in recent years because it can avoid drug metabolism and various side effects caused by the first pass effect of the liver. And the medicine can be taken for a long time. Among them, because the administration operation is simple and the dosage can be strictly controlled, adhesive preparations for transdermal absorpti...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61K9/70A61K47/10A61K47/14A61K47/32A61P9/06A61P9/10A61P9/12
Inventor 岩男美宏大久保胜之冈田胜博南邦弘汤浅修一朗
Owner NITTO DENKO CORP
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