Compositions comrrising amlodipine and bisoprolol

A kind of technology of amlodipine base and amlodipine besylate, applied in the field of solid pharmaceutical compositions
CN102164585AActive Publication Date: 2011-08-24EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (EGIS PHARMA PLC)
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (EGIS PHARMA PLC)
Publication Date
2011-08-24

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Abstract

Stable solid pharmaceutical composition containing amlodipine or pharmaceutical acceptable salts thereof and bisoprolol or pharmaceutical acceptable salts thereof as well as pharmaceutically accepted excipients, packaged in a damp- proof package and further comprising less than 0.5 % of the compound of the formula (3) based on the weight of the active ingredients.
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Description

technical field

[0001] The present invention relates to a stable solid pharmaceutical composition containing amlodipine and bisoprolol of the formula as active ingredients

[0002]

[0003] More particularly, the present invention relates to a composition packed in a moisture-proof package, which contains amlodipine base or a pharmaceutically acceptable salt thereof, preferably amlodipine besylate and pesofumarate of the formula Lol

[0004]

[0005] Further contain fillers, disintegrants, lubricants and anti-adhesion agents (anti-adhesion agent) used in the pharmaceutical industry, in addition, wherein the compound N-(2-{[4 -(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydro-2-pyridyl]-methoxy}-ethyl )-aspartic acid in an amount not exceeding 0.5%

[0006] Background technique

[0007] According to "evidence-based" therapeutic practice, blood pressure values ​​required to reduce the risk of cardiovascular morbidity and mortality can be ...

Claims

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