Bisoprolol-containing adhesive patch and package of same

A bisoprolol and packaging technology, applied in the field of bisoprolol-containing patch and its packaging, can solve the problems of no revelation, no revelation, stability of bisoprolol over time, etc., and achieve usability and portability Excellent, improved stability and reliability over time, and improved economical efficiency

Inactive Publication Date: 2016-04-20
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned patent documents do not suggest the improvement of the stability over time of bisoprolol

Method used

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  • Bisoprolol-containing adhesive patch and package of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] 15.1 parts of high molecular weight polyisobutylene (viscosity average molecular weight = 4,000,000), 26.1 parts of medium molecular weight polyisobutylene (viscosity average molecular weight = 55,000), 27.4 parts of alicyclic saturated hydrocarbon resin (tackifier), isopropyl myristate ( 30.0 parts of organic liquid components) and 1.4 parts of bisoprolol (free body) were mixed in toluene to prepare a viscous toluene solution of the adhesive composition. The obtained solution was coated on a polyethylene terephthalate (PET) release liner (thickness: 75 μm) so that the thickness after drying was 160 μm, and it was dried in a hot air circulation dryer. Drying was carried out at 100° C. for 5 minutes to form an adhesive layer.

[0097] The pressure-sensitive adhesive layer was bonded to a PET film and a PET nonwoven fabric (weight per unit area=12 g / m2) having a thickness of 2 μm. 2 ) The non-woven side of the support of the laminated film, punched into 36cm 2 (6 cm x 6...

Embodiment 2

[0101] Under an inert gas atmosphere, make 70.0 parts of 2-ethylhexyl acrylate, 5.0 parts of hydroxyethylacrylamide, 25.0 parts of N-vinyl-2-pyrrolidone, and 0.2 parts of azobisisobutyronitrile as a polymerization initiator in Solution polymerization was carried out at 60°C in ethyl acetate to prepare an acrylic adhesive solution. 65.0 parts of this acrylic adhesive solution, 30.0 parts of isopropyl myristate as an organic liquid component, and 5.0 parts of bisoprolol (free body) were mixed to prepare a viscous ethyl acetate of an adhesive composition. solution. The obtained solution was coated on a polyethylene terephthalate (PET) release liner (thickness 75 μm) so that the thickness after drying was 45 μm, and it was dried in a hot air circulation dryer at 100 °C for 5 minutes to form an adhesive layer.

[0102] The pressure-sensitive adhesive layer was bonded to a PET film and a PET nonwoven fabric (weight per unit area=12 g / m2) having a thickness of 2 μm. 2 ) on the non...

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Abstract

The present invention relates to: a bisoprolol-containing adhesive patch which comprises a supporting body and an adhesive layer that is formed on at least one surface of the supporting body and contains bisoprolol, and wherein the adhesive layer has a moisture content of 10,000 ppm or less; and a package of a bisoprolol-containing adhesive patch, which is obtained by sealing the bisoprolol-containing adhesive patch in a bag that has resistance to water vapor permeation. A bisoprolol-containing adhesive patch according to the present invention achieves excellent long-term stability of bisoprolol that is contained in the adhesive layer. In addition, a package of a bisoprolol-containing adhesive patch according to the present invention has excellent usability and portability.

Description

technical field [0001] The present invention relates to a bisoprolol-containing patch and its package. Background technique [0002] In recent years, as means for administering drugs into the living body, patches in which a drug-containing adhesive sheet is attached to the skin have been used. For such a patch, an adhesive layer containing a transdermally absorbable drug is laminated on one side of a plastic support such as polyester or polyethylene, and the exposed surface of the adhesive layer is covered with a release liner. Pad covered. Usually, such a patch is individually packaged in a water-impermeable packaging material in order to prevent volatilization of the transdermally absorbable drug contained therein and the influence of humidity. [0003] Bisoprolol, a highly selective antagonist of β1 receptors of the sympathetic nerve (β blocker), is used to improve essential hypertension, angina pectoris, arrhythmia, and its fumarate is given orally in the form of table...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61J1/00A61K9/70A61K47/32A61P9/06A61P9/10A61P9/12A61P43/00
CPCA61J1/10A61J1/16A61K9/7061A61K31/138A61P9/06A61P9/10A61P9/12A61P43/00
Inventor 石仓准青柳和宏雨山智漆原直子田中智也中村哲也
Owner NITTO DENKO CORP
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