Adhesive medicament preparation containing bisoprolol

A technology for bisoprolol and pharmaceutical preparations, applied in the field of adhesive pharmaceutical preparations, can solve the problems of difficult drug stability and skin irritation, and achieve the effects of low irritation and good adhesion

Inactive Publication Date: 2014-04-09
NITTO DENKO CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this formulation, it is difficult to say that the stability of the drug and the skin irritation caused by the drug have been sufficiently studied, leaving room for improvement

Method used

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  • Adhesive medicament preparation containing bisoprolol
  • Adhesive medicament preparation containing bisoprolol
  • Adhesive medicament preparation containing bisoprolol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 9 and comparative example 1 to 3

[0101] A toluene viscous solution of the composition for forming the adhesive layer was prepared according to the proportion shown in Table 1, and applied to a plastic film made of polyethylene terephthalate (PET) on which the silicone release treatment had been carried out. on a liner (75 μm thick) so that the thickness after drying becomes 80 μm. It was dried at 100° C. for 5 minutes in a hot air circulation type drying oven to produce an adhesive layer. The adhesive layer was bonded together with a lamination film consisting of a 2 μm thick PET film with a 12 g / m 2 Made of PET non-woven fabric. The PET liner on the laminated thin layer was peeled off to expose the adhesive surface on which one or two adhesive layers having the same composition and thickness as above were laminated to produce an adhesive layer of 160 μm or 240 μm Thick adhesive preparation. The proportioning amounts of the respective components described in Table 1 are illustrated by the percentage (% by ...

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Abstract

It is intended to provide an adhesive preparation which has a low irritation to the skin surface, is excellent in stability of bisoprolol in the preparation and further is capable of continuously administrating a pharmacologically effective amount of bisoprolol to the living body. The adhesive preparation 10 has a support 1 and an adhesive layer 2 which is layered on one surface of the support 1. The adhesive layer 2 is characterized by containing bisoprolol, polyisobutylene, a tackifier and an organic liquid component which is compatible with polyisobutylene and the tackifier. By this, the adhesive preparation having good skin adhesiveness, low skin irritation and reduced pain or adhesive residue at the time of removal from the skin surface can be provided. Further, the adhesive preparation in which the stability of bisoprolol in the adhesive preparation is excellent and the pharmacologically effective amount of bisoprolol can be continuously administrated to the living body through the skin surface is provided.

Description

technical field [0001] The present invention relates to an adhesive pharmaceutical formulation containing bisoprolol for the continuous absorption of bisoprolol into the body through the skin surface. Background technique [0002] Bisoprolol, a highly selective beta- 1 - Receptor antagonist, and its fumarate salt has been used as a tablet for oral administration. [0003] On the other hand, as a pharmaceutical preparation for treating or preventing diseases by administering live drugs, a percutaneous absorption preparation has received great attention in recent years because it can avoid drug metabolism and various side effects caused by the hepatic first-pass effect, And the medicine can be taken for a long time. Among them, since the administration operation is simple and the dose can be strictly controlled, percutaneously absorbed adhesive preparations have been gradually developed, in which an adhesive layer containing a drug is attached to the skin surface. Since adh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/138A61K9/70A61K47/10A61K47/14A61K47/32A61P9/06A61P9/10A61P9/12
Inventor 岩男美宏大久保胜之冈田胜博南邦弘汤浅修一朗
Owner NITTO DENKO CORP
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