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Enteric sustained-release preparation with aspirin and bisoprolol as active ingredients

A technology of aspirin and bisoprolol, applied in the field of medicine, can solve the problems of increased gastric damage and large losses

Inactive Publication Date: 2013-03-13
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because aspirin has a greater loss to the stomach, it increases the risk of gastric damage in patients, especially for patients with a history of ulcers. Therefore, for long-term use of aspirin for antithrombotic therapy, the dosage is small to reduce damage to the stomach, but Risks still exist, so finding ways to reduce gastric irritation from aspirin is a worthwhile research direction

Method used

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  • Enteric sustained-release preparation with aspirin and bisoprolol as active ingredients
  • Enteric sustained-release preparation with aspirin and bisoprolol as active ingredients
  • Enteric sustained-release preparation with aspirin and bisoprolol as active ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Aspirin Extended Release and Bisoprolol Bilayer Tablets

[0015]

[0016] Preparation method: aspirin crushed, spare. Povidone was dissolved in absolute ethanol for later use. Mix aspirin and auxiliary materials evenly, add binder (povidone absolute ethanol solution) to granulate, dry, and granulate. The bisoprolol is pulverized, and other auxiliary materials are added and mixed evenly. The two active ingredient material mixtures are respectively placed in two different feeding hoppers, and a double-layer tablet pressing process is adopted to prepare the compound double-layer tablet of the target preparation.

Embodiment 2

[0018] Aspirin Extended Release and Bisoprolol Film Coated Tablets

[0019]

[0020] Preparation method:

[0021] 1. Crush the aspirin and keep it for later use. Polyvinylpyrrolidone was dissolved in ethanol for later use. Mix the aspirin and auxiliary materials evenly, add polyvinylpyrrolidone absolute ethanol solution to granulate, dry, granulate, and compress into tablets.

[0022] 2. Dissolve HPMC E5 and polyethylene glycol 8000 in water, add bisoprolol and talcum powder, and homogenize through a colloid mill for about 5 minutes.

[0023] 3. Put the aspirin tablets into the coating pan, adjust the air inlet temperature to keep the material temperature at about 45°C, then adjust the spray gun atomization pressure, air flow rate and liquid medicine flow rate, and spray it to get the product

Embodiment 3

[0025] Aspirin enteric-coated sustained-release pellets and bisoprolol immediate-release pellets

[0026]

[0027] Preparation method:

[0028] 1. Grind aspirin and tartaric acid, add microcrystalline cellulose, starch and other auxiliary materials and mix well; set aside

[0029] 2. Configure 20% starch slurry, and use starch slurry as a binder to prepare soft materials.

[0030] 3. Put the soft material into the extruding spheronizer, extrude it into a long strip, and then put it into the shot blasting machine, adjust the rotation at 600-800rpm, and perform shot blasting to get small pellets with a particle size between 40-12 mesh , sieve, and take the drug-loaded pills with a particle size between 24-12 mesh

[0031] 4. Put the above drug-loaded pellets into the fluidized bed (Shenzhen Xinyite, MINI fluidized bed), adjust the material temperature to about 40°C, the inlet air temperature to 80-100°C, the atomization pressure and fluidization pressure 0.1Mpa respectivel...

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Abstract

The invention provides an enteric sustained-release preparation with aspirin and bisoprolol as active ingredients. The sustained-release oral solid preparation is produced from aspirin and bisoprolol which are as major ingredients and pharmaceutically acceptable auxiliaries through a preparation technology, and comprises but is not limited to a sustained-release tablet, a sustained-release two-layer tablet, a sustained-release capsule, a sustained-release granule and a sustained-release pill. The sustained-release oral solid preparation is characterized in that the bisoprolol is released in a quick release manner while the aspirin is released in a sustained release manner, and the sustained release manner can be realized through a sustained-release framework material and a framework forming agent or through a drug coating.

Description

technical field [0001] The invention relates to an enteric-coated slow-release preparation with aspirin and bisoprolol as active components, and belongs to the technical field of medicine. Background technique [0002] One of the serious consequences of hypertension is a significant increase in the incidence of cardiovascular and cerebrovascular diseases (angina pectoris, myocardial infarction, cerebral infarction, etc.), which is the most important cause of disability and death due to hypertension. Data from my country's "Tenth Five-Year Research Project" shows that the incidence of coronary heart disease events in hypertensive patients with systolic blood pressure of 140-159 mm Hg, 160-179 mm Hg, and ≥180 mm Hg is 4 times and 10 times that of normal blood pressure patients, respectively. And 25 times. Therefore, the prevention of cardiovascular and cerebrovascular diseases is one of the important goals of hypertension treatment. The guidelines for the prevention and treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K31/138A61K9/24A61K9/28A61K9/48A61P9/12A61P9/10
Inventor 不公告发明人
Owner FUKANGREN BIO PHARMA
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