Enteric sustained-release preparation with aspirin and bisoprolol as active ingredients

Abstract

The invention provides an enteric sustained-release preparation with aspirin and bisoprolol as active ingredients. The sustained-release oral solid preparation is produced from aspirin and bisoprolol which are as major ingredients and pharmaceutically acceptable auxiliaries through a preparation technology, and comprises but is not limited to a sustained-release tablet, a sustained-release two-layer tablet, a sustained-release capsule, a sustained-release granule and a sustained-release pill. The sustained-release oral solid preparation is characterized in that the bisoprolol is released in a quick release manner while the aspirin is released in a sustained release manner, and the sustained release manner can be realized through a sustained-release framework material and a framework forming agent or through a drug coating.

Description

technical field

[0001] The invention relates to an enteric-coated slow-release preparation with aspirin and bisoprolol as active components, and belongs to the technical field of medicine. Background technique

[0002] One of the serious consequences of hypertension is a significant increase in the incidence of cardiovascular and cerebrovascular diseases (angina pectoris, myocardial infarction, cerebral infarction, etc.), which is the most important cause of disability and death due to hypertension. Data from my country's "Tenth Five-Year Research Project" shows that the incidence of coronary heart disease events in hypertensive patients with systolic blood pressure of 140-159 mm Hg, 160-179 mm Hg, and ≥180 mm Hg is 4 times and 10 times that of normal blood pressure patients, respectively. And 25 times. Therefore, the prevention of cardiovascular and cerebrovascular diseases is one of the important goals of hypertension treatment. The guidelines for the prevention and treatm...

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