Supercharge Your Innovation With Domain-Expert AI Agents!

Quetiapine sustained release tablets and method of preparing the same

A sustained-release tablet and gentle technology, which is applied in the field of quetiapine sustained-release tablets and its preparation, can solve problems such as unclear absorption sites, and achieve the effects of convenient taking, good sustained-release performance, and reduced dosage

Active Publication Date: 2009-01-21
SHANDONG BESTCOMM PHARMA CO LTD
View PDF5 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

April D. Miller et al also reported in Am J Health-SystPharm.2006, 63(1): 1852-1857 that the exact absorption site of quetiapine in the body is not clear, but quetiapine is absorbed rapidly after administration, so it is speculated that It is absorbed in the stomach and intestines

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quetiapine sustained release tablets and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Quetiapine Fumarate 345g

[0031] Eudragit L 100-55 28g

[0032] Microcrystalline Cellulose 80g

[0033] Lactose 80g

[0034] Magnesium Stearate 6g

[0035] Gastric Opadry 12g

[0036] Preparation method: mix quetiapine fumarate, Eudragit L 100-55, microcrystalline cellulose, and lactose evenly, add hydroalcoholic solution to prepare soft material, granulate, dry, granulate, add magnesium stearate, mix evenly, Compressed tablets, coated with gastric Opadry.

Embodiment 2

[0038] Quetiapine Fumarate 345g

[0039] Eudragit L 100-55 50g

[0040] Eudragit NE 30D 100g

[0041] Microcrystalline Cellulose 50g

[0042] Lactose 50g

[0043] Magnesium Stearate 5g

[0044] Preparation method: mix quetiapine fumarate, Eudragit L 100-55, microcrystalline cellulose, and lactose evenly, prepare soft material with Eudragit NE 30D aqueous dispersion, granulate, dry, granulate, and add magnesium stearate Mix well and press into tablets.

Embodiment 3

[0046] Quetiapine Fumarate 345g

[0047] Eudragit L 100-55 80g

[0048] Microcrystalline Cellulose 50g

[0049] Lactose 50g

[0050] Sodium citrate 50g

[0051] Sodium hydroxide 3g

[0052] Magnesium Stearate 6g

[0053] Preparation method: mix quetiapine fumarate, Eudragit L 100-55, microcrystalline cellulose, and lactose evenly, add 1.5% sodium hydroxide solution to prepare soft material, granulate, dry, granulate, add magnesium stearate Mix well and press into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of pharmaceutical preparations, more specifically relates to a seroquel sustained release tablet and a preparation method thereof. The sustained release tablet of the invention comprises 5%-50% of sustained release framework material with pH-dependent solubility according to weight percentage, and preferably comprises 15%-35% of the sustained release framework material with the pH-dependent solubility. The seroquel sustained release tablet prepared by the invention runs in the gastrointestinal tract by imitating sustained release and controlled release agents, the in vitro release rate thereof is determined, which proves that the sustained seroquel release tablet can continuously release for 6-24 hours. The seroquel sustained release tablet of the invention reduces dosage of sustained release material based on good sustained release performance and facilitates the administration of patients. The seroquel sustained release tablet of the invention has simple technology and is good for large-scale industrialized production at the same time.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, more specifically, the invention relates to a quetiapine sustained-release tablet and a preparation method thereof. Background technique [0002] Quetiapine (Quetiapine) is an atypical antipsychotic drug, its structure is similar to clozapine, it belongs to dibenzodiazepine derivatives, it not only retains the curative effect characteristics of clozapine but also overcomes its agranulocytosis, Obesity, anticholinergic and other adverse reactions. The drug mainly acts on 5-HT 2 、D 1 、D 2 and D 4 Receptor, it has positive curative effect on schizophrenia, mild side effects and good safety. Compared with traditional antipsychotic drugs, due to the interaction with 5-HT 2 Receptor affinity compared to D 1 and D 2 The receptor is strong, and the 5-HT / DA receptor binding ratio is greater than 2, so it is not only effective for positive symptoms of schizophrenia, but also effective for...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/22A61K31/554A61P25/18
Inventor 赵广强安芳贤张宇红
Owner SHANDONG BESTCOMM PHARMA CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com