One-step method preparation process of treatment type drug resistant AIDS (acquired immunodeficiency syndrome) autologous plasma virus inactivated vaccine

A technology of virus inactivation and autologous plasma, applied in the direction of viruses, antiviral agents, virus antigen components, etc., can solve the problem of not finding a way to overcome AIDS, reduce the cost of preparation and application, reduce the intensity of infection and the number of sources of infection , good application and promotion prospects

Pending Publication Date: 2018-09-07
耿艳春 +1
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The main reason is that the existing research and development ideas and conceptual design have not yet found a path and specific method that can overcome

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  • One-step method preparation process of treatment type drug resistant AIDS (acquired immunodeficiency syndrome) autologous plasma virus inactivated vaccine

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Embodiment Construction

[0025] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0026] The preparation process of the present invention includes: blood collection-plasma separation-virus inactivation from HIV / AIDS infected persons, directly preparing a therapeutic AIDS autologous plasma virus inactivated vaccine, and autologous infusion inoculation of the AIDS patient.

[0027] Concrete preparation process steps are as follows:

[0028] Step 1, centrifugal plasma virus species separation.

[0029] The multi-generational HIV carried in the plasma of drug-resistant HIV / AIDS infected persons is used as the virus seed for the preparation of specific therapeutic vaccines, and the DiZiPia-90 centrifugal plasma exchange machine and the P-1000 primary Sexual apheresis plasma separator, blood preservation solution (1), in accordance with the program operation steps and parameters set by the plasma exchange machine, with conventio...

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Abstract

The invention relates to a one-step method preparation process of treatment type drug resistant AIDS (acquired immunodeficiency syndrome) autologous plasma virus inactivated vaccine. Through blood collection, plasma separation and plasma virus inactivation, the vaccine is directly prepared; then, intravenous vaccination is performed; the whole process is completed in a sealed disposable consumable; the pollution risk in the preparation process can be effectively avoided; the vaccine preparation safety is ensured. The preparation process is simple; the cost is low; the inoculation procedure canalso be simplified; the technical requirements of large-dose (600 to 800ml) plasma virus inactivated vaccine inoculation are met. More importantly, the virus strain of the inactivated vaccine is froma patient self; the plasma is also from the patient self; the obvious safety, effectiveness and feasibility are realized. The principle of medical ethics is conformed; the problem of animal model lack of AIDS vaccine development can also be solved. The vaccine is applicable to the continuous treatment of AIDS patients with drug resistance and treatment failure, initial and conventional treatmenton AIDS patients without drug resistance, and emergent blockade treatment on occupational exposure persons.

Description

technical field [0001] The invention relates to a preparation process of plasma virus inactivated vaccine, in particular to a one-step preparation process of therapeutic drug-resistant AIDS autologous plasma virus inactivated vaccine. It is applicable to the prevention and treatment of AIDS, especially the treatment of HIV drug resistance and treatment failure patients. Background technique [0002] AIDS is a new special health problem and public health problem that mankind is facing. It is also a hot spot and problem that the whole world is paying attention to. Since its discovery in 1981, the catastrophic harm to human beings has been known all over the world for 36 years. According to figures released by the World Health Organization, AIDS has caused more than 35 million deaths so far. In 2016, there were still 36.7 million HIV-infected people in the world, about 1.8 million newly-infected people, and 1 million people died of AIDS that year. Although countries have inv...

Claims

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Application Information

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IPC IPC(8): A61K39/21A61P31/18
CPCA61K39/12A61K2039/5252A61K2039/572A61K2039/575A61P31/18C12N2740/16234
Inventor 孙昊明孙刚孙锦山耿艳春孙琪
Owner 耿艳春
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