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Medicinal composition for treating acquired immune deficiency syndrome (Aids) as well as preparation method, quality control method and application thereof
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A composition and drug technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, antiviral agents, etc., can solve problems such as the curative effect needs to be improved
Active Publication Date: 2012-08-22
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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preparation example Construction
[0043] The preparation method of above-mentioned pharmaceutical composition, comprises the steps:
[0044] 1) Take the crude drug, decoct it with water, filter, and take the filtrate;
[0045] 2) centrifuging the filtrate, taking the supernatant, concentrating, and extracting the concentrate with water;
[0046] 3) adding ethanol to the concentrated water extract, stirring, standing still, and then centrifuging, taking the supernatant, removing ethanol, and obtaining the ethanol extract;
[0047] 4) Prepare the pharmaceutical preparation by combining the alcohol extract and other acceptable pharmaceutical excipients.
[0048] Furthermore, its preparation method includes the following steps:
[0049] 1) Take the raw materialdrug, add water to decoct 3 times, add 20 times the amount of water each time, decoct for 2 hours, let cool, filter, and combine the filtrate;
[0050] 2) Centrifuge the filtrate, take the supernatant and concentrate it to the weight of the raw material ...
[0073] 25 parts of cooked aconite, 12.5 parts of epimedium, 12.5 parts of dried ginger, 12.5 parts of licorice, 7.82 parts of red ginseng, 7.81 parts of poria cocos, 7.81 parts of knotweed, 7.81 parts of salvia miltiorrhiza, 3.75 parts of Phellodendron phellodendri, and 2.5 parts of skullcap.
[0076] 20 parts of cooked aconite, 14 parts of epimedium, 15 parts of dried ginger, 10 parts of licorice, 10 parts of red ginseng, 12 parts of poria cocos, 6 parts of knotweed, 10 parts of salvia miltiorrhiza, 5 parts of Phellodendron phellodendri, and 3 parts of skullcap.
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Abstract
The invention discloses a medicinal composition for treating acquired immune deficiency syndrome (Aids) as well as a preparation method, quality control method and application of the medicinal composition. The raw materials of the medicinal composition comprise cooked monkshood, herba epimedii, dried ginger, liquorice, ginseng, the root of red-rooted salvia, giant knot weed, Poria cocos, golden cypress and Scutellaria baicalensis. Experimental data indicate that the medicinal composition preparation disclosed by the invention has Aids treating function on Aids model monkeys derived from rhesus monkeys infected by monkey Aids Virus, based on the curative effect on the Aids monkey models adaptive to Aids animal models, the medicinal composition preparation has the application of treating human Aids; after being given to HIV infected persons or Aids patients, the medicinal composition preparation can relieve disease, i stabilize or improvethe CD4+T lymphocyte count level of the HIV infected persons or the Aids patients, relieve clinical clinical symptoms and improve survival quality.
Description
technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating AIDS. The invention also relates to a quality control method and use of the composition. Background technique [0002] AIDS is an acquired immunodeficiency syndrome caused by HIV infection. The clinical manifestations of different stages of HIV infection process and pathogenesis are complex and diverse, including fatal malignant tumors and various opportunistic infections that occur later. [0003] People generally enter the onset period after 7-12 years after being infected with HIV-1. According to the current standard of diagnosis and treatment, antiviral therapy is not recommended for HIV carriers who are asymptomatic and whose CD+ T cell count has not been greatly reduced (for example, still above 300 per microliter), otherwise it will cause patients and society Take the huge risk of inducing severe drug resistance. According to the ...
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