Method of making a packaged antimicrobial suture

a medical device and antimicrobial technology, applied in the direction of packaging foodstuffs, containers preventing decay, packaging goods, etc., can solve the problems of significant increase in the cost of treatment for patients, limited shelf life of packaged medical devices having antimicrobial properties, infection and trauma to patients, etc., to achieve the effect of improving shelf li

Inactive Publication Date: 2012-02-14
ETHICON INC
View PDF121 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]In one aspect, disclosed herein is a method of making a packaged antimicrobial suture having improved shelf life. The method includes the steps of providing an inner package having a source of antimicrobial agent, providing an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, positioning a suture within the inner package, the suture comprising one or more surfaces, covering the inner package with an outer package having an inner surface and subjecting the suture, the inner package and the inner surface of the outer package to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture and the inner package, thereby substantially inhibiting bacterial colonization on the suture and the inner package, wherein the packaged antimicrobial suture exhibits improved shelf life.
[0019]The present invention is also directed to a method of increasing the shelf life of a packaged antimicrobial medical device. The method includes the steps of providing an inner package having a source of antimicrobial agent, providing an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, positioning a medical device within the inner package, the medical device comprising one or more surfaces, covering the inner package with an outer package having an inner surface and subjecting the medical device, the inner package and the inner surface of the outer package to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device and the inner package, thereby substantially inhibiting bacterial colonization on the medical device and the inner package, wherein the packaged antimicrobial medical device exhibits improved shelf life.
[0020]The present invention also relates to a packaged antimicrobial suture having improved shelf life. The packaged antimicrobial suture includes an inner package having a source of antimicrobial agent and an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, a suture positioned within the inner package, the suture comprising one or more surfaces and an outer package having an inner surface, the outer package having the inner package positioned within, wherein the suture, the inner package and the inner surface of the outer package are subjected to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture and the inner package, thereby substantially inhibiting bacterial colonization on the suture and the inner package.
[0021]In one embodiment the packaged antimicrobial suture exhibits improved shelf life.

Problems solved by technology

Such bacterial colonization on the medical device may lead to infection and trauma to the patient.
Accordingly, SSIs may significantly increase the cost of treatment to patients.
Packaged medical devices having antimicrobial properties may exhibit a limited shelf life.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of making a packaged antimicrobial suture
  • Method of making a packaged antimicrobial suture
  • Method of making a packaged antimicrobial suture

Examples

Experimental program
Comparison scheme
Effect test

example 1

PDS Plus Size 1 in Universal Folder stored at 25° C.

[0099]Stability studies were run using size 1 PDS Plus® sutures, packaged in universal folders. For each study the finished product was stored at 25° C. for up to 24 months. Samples were tested for triclosan content in the suture and compared to the starting values. Results for these studies are presented below and graphically depicted in FIG. 7.

[0100]

VAP2005-003 - Uncoated PaperVAP2007-058 - Coated PaperPercentTriclosan (ppm)Percent IncreaseTriclosan (ppm)Increase2.5 mg (1)3.6 mg (1)2.5 mg (1)3.6 mg (1)2 mg4 mg2 mg4 mgAve4.2 mg (3 / 0)4.66 mg (3 / 0)4.2 mg (3 / 0)4.66 mg (3 / 0)AveStorageTriclosanTriclosanTriclosanTriclosanUFTriclosanTriclosanTriclosanTriclosanUFTimeDispenseDispenseDispenseDispenseIncreaseDispenseDispenseDispenseDispenseIncreaseSize(Months)AmountAmountAmountAmount(%)AmountAmountAmountAmount(%)10208334910.0%0.0%0.0%155923140.0%0.0%0.0%112313286011.0%−18.1%−3.5%155921980.0%−5.0%−2.5%132582358024.0%2.5%13.3%164822755.7%−1.7%...

example 2

PDS Plus Size 3 / 0 in Universal Folder stored at 25° C.

[0101]Stability studies were run using size 3 / 0 PDS Plus® sutures, packaged in universal folders. For each study the finished product was stored at 25° C. for up to 24 months. Samples were tested for triclosan content in the suture and compared to the starting values. Results for these studies are presented below and graphically depicted in FIG. 8.

[0102]

VAP2007-058 - Coated PaperVAP2005-003 - Uncoated PaperTriclosan (ppm)Percent IncreaseTriclosan (ppm)Percent Increase2.5 mg (1)3.6 mg (1)2.5 mg (1)3.6 mg (1)2 mg4 mg2 mg4 mgAve4.2 mg (3 / 0)4.66 mg (3 / 0)4.2 mg (3 / 0)4.66 mg (3 / 0)AveStorageTriclosanTriclosanTriclosanTriclosanUFTriclosanTriclosanTriclosanTriclosanUFTimeDispenseDispenseDispenseDispenseIncreaseDispenseDispenseDispenseDispenseIncreaseSize(Months)AmountAmountAmountAmount(%)AmountAmountAmountAmount(%)3 / 0150788761−10.3%33.2%11.5%547856984.6%1.9%3.3%3 / 03595883575.2%27.1%16.2%560960817.1%8.8%7.9%3 / 0562841050811.0%59.8%35.4%5611...

example 3

PDS Plus Size 1 in Universal Folder stored at 50° C.

[0103]Stability studies were run using size 1 PDS Plus® sutures, packaged in universal folders. For each study the finished product was stored at 50° C. for up to 5 months. Samples were tested for triclosan content in the suture and compared to the starting values. Results for these studies are presented below and graphically depicted in FIG. 9.

[0104]

VAP2007-058 - Coated PaperVAP2005-003 - Uncoated PaperTriclosan (ppm)Percent IncreaseTriclosan (ppm)Percent Increase2.5 mg (1)3.6 mg (1)2.5 mg (1)3.6 mg (1)2 mg4 mg2 mg4 mgAve4.2 mg (3 / 0)4.66 mg (3 / 0)4.2 mg (3 / 0)4.66 mg (3 / 0)AveStorageTriclosanTriclosanTriclosanTriclosanUFTriclosanTriclosanTriclosanTriclosanUFTimeDispenseDispenseDispenseDispenseIncreaseDispenseDispenseDispenseDispenseIncreaseSize(Months)AmountAmountAmountAmount(%)AmountAmountAmountAmount(%)10208334910.0%0.0%0.0%155923140.0%0.0%0.0%1145878492120.2%143.3%131.7%2130297436.6%28.5%32.6%13519611593149.4%232.1%190.8%245535495...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
temperatureaaaaaaaaaa
temperatureaaaaaaaaaa
temperatureaaaaaaaaaa
Login to view more

Abstract

A method of making a packaged antimicrobial suture having improved shelf life. The method comprising the steps of providing an inner package having a source of antimicrobial agent, providing an adsorbent material effective to adsorb a portion of the antimicrobial agent over time, positioning a suture within the inner package, the suture comprising one or more surfaces, covering the inner package with an outer package having an inner surface and subjecting the suture, the inner package and the inner surface of the outer package to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture and the inner package, thereby substantially inhibiting bacterial colonization on the suture and the inner package, wherein the packaged antimicrobial suture exhibits improved shelf life. A packaged antimicrobial suture and a method of increasing the shelf life of a packaged antimicrobial medical device are also provided.

Description

CROSS-REFERENCE TO PRIOR APPLICATIONS[0001]This application is a continuation-in-part of U.S. Ser. No. 12 / 415,600, filed on Mar. 31, 2009, which is a continuation-in-part of U.S. Ser. No. 11 / 301,365, filed on Dec. 13, 2005, now U.S. Pat. No. 7,513,093, and U.S. Ser. No. 11 / 301,364, filed on Dec. 13, 2005, now allowed, each of which is a continuation-in-part of U.S. Ser. No. 10 / 808,669, filed on Mar. 25, 2004, now abandoned, which is a continuation-in-part of U.S. Ser. No. 10 / 603,317 filed on Jun. 25, 2003, now abandoned, which is a continuation-in-part of U.S. Ser. No. 10 / 367,497 filed on Feb. 15, 2003, now abandoned, which claimed the benefit of U.S. Provisional Application No. 60 / 416,114 filed on Oct. 4, 2002, the contents of each are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention relates to an antimicrobial medical device and an antimicrobial packaged medical device and their methods of making.BACKGROUND OF THE INVENTION[0003]...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(United States)
IPC IPC(8): B65B55/22
CPCA61B17/06114A61B17/06138A61L17/005A61B17/06166A61B2017/00526A61L2300/404A61B2017/06142A61B2019/0267A61B2017/00889A61B2050/314A61B17/04
Inventor FISCHER, JERRYSCALZO, HOWARDPOKROPINSKI, JR., HENRY
Owner ETHICON INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap