The present invention relates to a preparation method and application of a supramolecular blue
copper peptide nanocomposite, and belongs to the technical field of
cosmetics. The structure of the supramolecular blue
copper peptide nanocomposite of the present invention is: Myr-RHKRHKRHK-[GHK-Cu]-X, wherein X is a negatively charged active substance. Specifically, the present invention is synthesized by Fmoc
solid phase method, modified by myristoyl, to obtain myristoyl dodecapeptide: Myr-(RHK)3GHK, a complexation reaction occurs in a
copper sulfate solution, to obtain a supramolecular blue copper
peptide: Myr-(RHK)3-[GHK-Cu], and the supramolecular blue copper peptide solution is compounded with a negatively charged active substance to obtain a supramolecular blue copper peptide
nanocomposite. Compared with commercially available blue copper peptides, the supramolecular blue copper peptide prepared by the present invention can self-assemble into nano micelles in a solution, form nanocomplexes with negatively charged active substances, can quickly penetrate the
skin, and has better stability, and can better solve the current problems of limited permeability and easy inactivation of blue copper peptides; it can directly target the inside of
skin cells, reduce the amount of active substances added, improve
bioavailability, and exert more excellent
efficacy; at the same time, the supramolecular blue copper peptide itself can be used as a carrier to form a supramolecular nanocomplex with negatively charged substances such as nucleic acids.