38 results about "Cytopenia" patented technology

The present invention relates to ketone derivatives represented by the following formula and medical agents containing the ketone derivatives or pharmacologically acceptable salts thereof as an active ingredient, and in particular, relates to a hematopoietic agent; it is shown that the present invention increases blood cells, such as platelets, white blood cells, and red blood cells, and is effective in preventing and treating cytopenia caused by cancer chemotherapy, radiation therapy, and the like.

This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among SCF, M-CSF, and G-CSF, and a method of growing hematopoietic stem cells which comprises culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF.The hematopoietic stem cell proliferating agent of the invention causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro and can, therefore, be used for amelioration of the cytopenia induced by radiotherapy or chemotherapy using anticancer drugs, prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and extrasomatic culture of recombinant stem cells in gene therapy.

An orally applied solid medicine of chlorophyll copper sodium in the form of tablet, slow-releasing tablet, or particle for treating cytopenia, thrombo cytopenia and bone marrow arrest is prepared from the chlorophyll copper sodium as active component and filler through wet process.

Provided is directed to the field of immunotherapy. Specifically, provided are compositions and methods for improved T cell modulation ex vivo and in vivo and for the treatment of cancer and other pathologies. More specifically, embodiments of the subject matter are directed to the use of soluble NTB-A polypeptides or agonists thereof for the treatment of cancer patients, for preventing and treating cytopenia in susceptible patients, and for the ex vivo preparation of improved cell compositions.

Aspects and embodiments of the instant disclosure provide therapeutic methods and compositions comprising interleukin 12 (IL-12) as a hematopoietic immunotherapy (HIT) useful for treating or preventing a cancer patient from chemotherapy-induced cytopenias necessitating a dose reduction and / or dose delay. following exposure of the patient to chemotherapeutic agents, the method comprising: administering a dose of therapeutically effective amount of a pharmaceutical composition comprising substantially isolated IL-12 to the subject, whereby cytopenias are reduced and leading to increases responses to the chemotherapy agent(s).diminished.

The present application relates to use of icaritin in preparing a medicament for preventing or treating hematocytopenia. Particularly, icaritin may be used to prevent or treat bone marrow suppression caused by chemotherapeutic drugs, and may also be used to prevent or treat thrombocytopenia, for example, immune thrombocytopenia.

The invention provides a compound preparation for treating pancytopenia, which is small in toxic and side effect and obvious in treatment effect. The compound preparation is mainly prepared from the following raw medical materials by weight percent: 15% to 18% of bovine bone marrow, 8% to 10% of placenta hominis, 8% to 10% of rehmannia glutinosa, 8% to 10% of Chinese yam, 8% to 10% of lycium barbarum, 8% to 10% of dogwood, 15% to 18% of medicinal cyathula root, 8% to 10% of deerhorn glue, 8% to 10% of semen cuscutae and 8% to 10% of tortoise plastron glue. According to the compound preparation, the functions of an ancient formula 'Zuogui Pill' capable of enriching yin and nourishing kidney as well as replenishing essence and benefiting marrow are utilized; and yang-tonifying medicines are added into the yin-tonifying formula, so that the compound preparation has the functions of enriching yin and nourishing the kidney, replenishing essence and benefiting marrow as well as reinforcing qi and nourishing blood under the formula synergy in manners of reinforcing yang from yin and reinforcing yin from yang.

The present invention describes methods and compositions for stimulating the growth, proliferation, differentiation and / or mobilization of stem cells and / or progenitor cells. The method involves administering an effective amount of a substance that activates a CD163 hemoglobin scavenger receptor signaling pathway. The methods and compositions are useful for stimulating hematopoiesis and treating a variety of disorders, including cytopenias, anemia, and for preparing cells for transplantation.

The invention relates to application of a compound as shown in the general formula (I) or pharmaceutically acceptable salt in the preparation of medicines for preventing and / or treating cytopenia of patents who will receive, is receiving or has received chemotherapy and drug therapy. In the general formula, R1, R2 and R3 can be the same or different and respectively and independently represent H or C1-C3 alkyl group. In comparison with common clinical drugs (such as G-CSF) for increasing haemocyte count for those who receive chemotherapy, the compound of the invention can remarkably increase hemocyte in those who receive chemotherapy, especially increase leucocyte, in particular the number of neutrophile granulocyte and monocyte. The compound of the invention has a good clinical prospect.

The invention discloses a regeneration soup of dragon and deer and a purpose thereof. The regeneration soup is a decoction prepared from Radix Astragali, deerhorn gelatin, donkey-hide gelatin, Agrimonia eupatoria, Pinus tabulaeformis Carr, Millettia dielsiana, Malaytea Scurfpea Fruit and licorice. The regeneration soup of the invention, which has the advantages of reasonable formula and good treatment effect, can effectively treat aplastic anemia, and various diseases of cytopenia, such as dizziness, palpitaition, lassitude and hypodynamia, purpura, or epistaxis and gringival hemorrhage.

The invention discloses a red ginseng and radix paeoniae alba Qi-benefiting and blood-nourishing granule traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is prepared by twelve raw material medicines, namely red ginseng, radix paeoniae alba, astragalus membranaceus, prepared rehmannia root, angelica sinensis, herba epimedii, morinda officinalis, teasel root, semen cuscutae, hairyvein agrimony, fried atractylodes rhizome and fructus amomi, and granules are prepared by water extraction, clear paste drying, crushing, adding dextrin and saccharose for uniform mixing and sub-package sequentially. The red ginseng and radix paeoniae alba Qi-benefiting and blood-nourishing granule traditional Chinese medicine composition is better in curative effect, reasonable in compatibility, synergistic in effect, explicit in efficacy, safe without any toxicand side effect, high in safety in case of long-term medication and incapable ofgenerating dependence. The red ginseng and radix paeoniae alba Qi-benefiting and blood-nourishing granule traditional Chinese medicine composition disclosed by the invention has the efficacies of benefiting Qi, promoting the secretion of saliva or body fluid, invigorating bone marrow to generate blood, tonifying kidney and Yang, tonifying spleen and invigorating stomach and is used for treating aplastic anemia, a myelodysplastic syndrome, thrombocytopenia, radiochemotherapy-induced hematopenia, Qi and blood deficiency and kidney-Yang insufficiency.

The present invention generally relates to compositions containing chemical compounds and compositions and pharmaceutical formulations of the compounds which increase the expression of total hemoglobin or globin protein such as embryonic or fetal globin, or the proliferation of hemoglobin expressing and other blood cells. These compositions can be used to treat or prevent the symptoms associated with anemia, sickle cell diseases, thalassemia, and other blood cell deficiencies and blood disorders. The invention also relates to methods for administering these compositions to subjects and for use as medical aids for the treatment and prevention of blood and other disorders.

The new applications of catechin and epicatechin, espeically for preventing and / or treating panhematopenia. Catechin or epicatechin could effectively treat panhematopenia caused by various reasons. The mechanism is catechin and epicatechin can increase the number of hematopoietic stem cell / progenitor cell in mice with marrow hemopoiesis inhibition, promote proliferation and differentiation, and thus increase three strains of blood cells to normal levels

The present invention concerns a compound consisting of RNA, in particular RNA extracted from yeast, a pharmaceutical composition comprising such RNA and a method for the treatment of inflammatory and inflammatory-related disorders comprising administering to a patient in need of such treatment a pharmaceutical composition comprising an amount effective to ameliorate the symptoms of inflammation or inflammatory-related disorder of ribonucleic acid and a pharmaceutically acceptable vehicle, carrier, or diluent. The exogenous yeast RNA used in the present invention has a pronounced membrane-stabilizing action in a wide range of concentrations. At the same time, yeast RNA normalizes metabolism of arachidonic acid and levels of its key metabolites, thromboxane and leukotriene. Its anti-inflammatory action is accompanied by normalization of the activity of NO-synthetase and anti-oxidant activity.

The invention provides a method for treatment of the diseases in a human by identifying the human as one suffering from a herpes simplex virus (HSV), and then administering to the human the compound anti-HSV agent or a pharmaceutically acceptable salt thereof. The diseases include dermatosis and non-dermatosis, wherein the dermatosis include acnes, impetigo, pyoderma gangrenosum, chilblains and psoriasiform, asteatotic dermatitis, ichthyosis, lichen simplex chronicus (Neurodermatitis, Prurigo), seborrhoeic dermatitis, rosacea, perioral dermatitis, epidermal cyst, wound ulcer, discoid lupus erythematosus, vitiligo, Alopecia, diagnostic criteria of some autoimmune diseases such as systemic lupus erythematosus or diabetic skin complications, wherein the non-dermatosis include glomerulonephritis, arthritis, Crohn's disease, ulcerative colitis, myelodysplasia, multiple myeloma, demyelinating disease, Parkinson's disease, anemia, cytopenia those among the diagnostic criteria.

The invention discloses a Chinese medicine preparation for treating pancytopenia. The Chinese medicine preparation comprises, by weight, 20-30 grams of curculigo, 10-20 grams of hairyvein agrimony, 10-20 grams of ginseng, 10-20 grams of caulis spatholobi, 10-20 grams of herba epimedii, 10-20 grams of psoralen, 10-20 grams of cistanche, 10-20 grams of morinda roots, 10-20 grams of astragalus, 8-15 grams of rhizoma Chuanxiong, 8-12 grams of the bark of eucommia, 8-12 grams of fructus amomi, 8-12 grams of gizzard pepsin, 8-12 grams of red peony, 8-12 grams of peach kernels, 8-15 grams of dipsacus roots, 8-15 grams of platycladi seeds and 8-15 grams of calamus. Medicines are excellent in compatibility, reasonable in composition, simple, convenient, easy, wide in medicine source, economical, practical, safe, reliable and worthy of clinical popularization, and jointly function in benefiting the liver, nourishing the kidney, supplementing qi, promoting the production of body fluid, promoting blood circulation, removing blood stasis, warming meridians, promoting circulation of qi and tranquilizing mind. The disease course can be obviously shortened when the Chinese medicine preparation is used for treating the pancytopenia, and treatment effects are improved.

The present invention relates to therapeutic uses of beta glucan for treating cancer, cytopenia, and symptoms associated with negative side effects of chemotherapy. As such, the current invention provides methods of using beta glucan for treating cancer, for increasing hematopoiesis, and for improving the quality of life of subjects undergoing chemotherapeutic treatment.

The invention relates to methods and compositions comprising a macrophage colony stimulating factor (M-CSF) polypeptide or an agonist of the M-CSF receptor for preventing or treating myeloid cytopenia and related complications (such as infections) in a patient in need thereof (such as a patient undergoing hematopoietic stem cell transplantation).

The invention provides a method for treatment of the diseases in a human by identifying the human as one suffering from a herpes simplex virus (HSV), and then administering to the human the compound anti-HSV agent or a pharmaceutically acceptable salt thereof. The diseases include dermatosis and non-dermatosis, wherein the dermatosis include acnes, impetigo, pyoderma gangrenosum, chilblains and psoriasiform, asteatotic dermatitis, ichthyosis, lichen simplex chronicus (Neurodermatitis, Prurigo), seborrhoeic dermatitis, rosacea, perioral dermatitis, epidermal cyst, wound ulcer, discoid lupus erythematosus, vitiligo, Alopecia, diagnostic criteria of some autoimmune diseases such as systemic lupus erythematosus or diabetic skin complications, wherein the non-dermatosis include glomerulonephritis, arthritis, Crohn's disease, ulcerative colitis, myelodysplasia, multiple myeloma, demyelinating disease, Parkison's disease, anemia, cytopenia those among the diagnostic criteria.

The invention relates to the combined use of selective serotonin reuptake inhibitors (SSRIs) and hematopoietic growth factors as a drug and particularly for treating cytopenia related to hematopoietic diseases or chemotherapy, and also to a pharmaceutical kit comprising both SSRIs and hematopoietic growth factors. This combination is more particularly used for treating patients presenting cytopenia, and patients in need of chemotherapy and more particularly to reduce length of chemotherapy-induced aplasia.

The invention provides a method for treatment of the diseases in a human by identifying the human as one suffering from a herpes simplex virus (HSV), and then administering to the human the compound anti-HSV agent or a pharmaceutically acceptable salt thereof. The diseases include dermatosis and non-dermatosis, wherein the dermatosis include acnes, impetigo, pyoderma gangrenosum, chilblains and psoriasiform, asteatotic dermatitis, ichthyosis, lichen simplex chronicus (Neurodermatitis, Prurigo), seborrhoeic dermatitis, rosacea, perioral dermatitis, epidermal cyst, wound ulcer, discoid lupus erythematosus, vitiligo, Alopecia, diagnostic criteria of some autoimmune diseases such as systemic lupus erythematosus or diabetic skin complications, wherein the non-dermatosis include glomerulonephritis, arthritis, Crohn's disease, ulcerative colitis, myelodysplasia, multiple myeloma, demyelinating disease, Parkinson's disease, anemia, cytopenia those among the diagnostic criteria.

The invention discloses a marrow-benefiting and blood-enriching pharmaceutical composition as well as a taking method and application thereof. After reasonable compatibility, the pharmaceutical composition plays a synergistic effect, acts on a new target, avoids side effects of traditional treatment drugs, has protection and hematopoiesis promoting effects on bone marrow cells, and is economical and practical and low in toxic and side effects. Wherein the tortoise-plastron glue, the deer-horn glue, the donkey-hide gelatin, the rhizoma curculiginis, the herba epimedii, the glossy privet fruit and the fructus psoraleae have the effects of tonifying kidney and marrow, replenishing essence and generating blood; poria cocos, rhizoma atractylodis, caulis spatholobi, radix paeoniae alba and liquorice have the effects of invigorating spleen, replenishing qi and generating blood; caulis Spatholobi is a product for enriching blood and activating blood, and can enrich blood, activate blood and remove blood stasis to promote new blood metaplasia; the hairyvein agrimony has the effects of regulating qi and blood and The raw materials have synergistic effects to tonify kidney and spleen, benefit marrow, replenish essence and produce blood, so that blood cells are improved. In clinical application, immune thrombocytopenia, chronic aplastic anemia and hemopenia caused by chemotherapeutic drugs can be effectively treated, and a safe and reliable new clinical drug is provided.

The present invention provides compositions comprising a 3′-OH, 5′-OH, chemically unmodified, synthetic phosphodiester nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, and a pharmaceutically acceptable carrier, wherein the compositions are useful to induce differentiation of cells or to stimulate differentiation or production of pluripotent cells. The present invention provides methods of using these compositions to induce differentiation of pluripotent cells, including bone marrow derived cells, and to treat disease associated with insufficient differentiation of cells in animals and humans, including but not limited to leukemia, lymphoma, non-malignant blood disorders such as hemoglobinopathies, sickle cell disease, myelodysplastic syndrome, pancytopenia, anemia, thrombocytopenia and leukopenia.

The invention discloses a regeneration soup of dragon and deer and a purpose thereof. The regeneration soup is a decoction prepared from Radix Astragali, deerhorn gelatin, donkey-hide gelatin, Agrimonia eupatoria, Pinus tabulaeformis Carr, Millettia dielsiana, Malaytea Scurfpea Fruit and licorice. The regeneration soup of the invention, which has the advantages of reasonable formula and good treatment effect, can effectively treat aplastic anemia, and various diseases of cytopenia, such as dizziness, palpitaition, lassitude and hypodynamia, purpura, or epistaxis and gringival hemorrhage.

The present invention relates to a use of a compound of general formula (I) or its pharmaceutically acceptable salt in preparing a drug for preventing and / or treating cytopenia of a subject to receive, currently receiving, or having received a chemotherapy drug treatment: , wherein R1, R2, and R3 can be identical or different, and independently represent an H or a C1-C3 alkyl group respectively. Compared with drugs commonly used to increase the blood cell count in a subject receiving chemotherapy in clinical practices, such as G-CSF, the compound in the present invention can significantly boost the number of blood cells in a subject receiving chemotherapy, particularly leukocytes, and more particularly neutrophils and monocytes. The compound in the present invention has promising future development in clinical applications.

The invention discloses a radix ginseng rubra and white paeony root capsule traditional Chinese medicine composition for reinforcing qi and nourishing blood and a preparation method thereof. The traditional Chinese medicine composition is prepared from 12 kinds of raw materials of the radix ginseng rubra, the white paeony root, radix astragali, radix rehmanniae preparata, radix angelicae sinensis,rhizome of longspur epimedium, radix morindae officinalis, dipsaci radix, the seed of Chinese dodder, agrimoniae herba, roasted rhizoma atractylodis macrocephalae and fructus amomi. A capsule is prepared by water extraction, drying of clear paste, pulverizing, adding of appropriate excipients, uniform mixing, granule preparation, drying, granule straightening and capsule filling. The traditionalChinese medicine composition has the advantages of better curative effect, reasonable compatibility, synergistic effect, clear efficacy, safety and no toxic and side effects, high safety in long-termuse and no generation of dependence. The traditional Chinese medicine composition has the effects of supplementing qi and promoting the production of body fluid, reinforcing marrow and generating blood, invigorating kidney and strengthening yang, and tonifying spleen and invigorating stomach. The traditional Chinese medicine composition is used for treating aplastic anemia, myelodysplastic syndrome, thrombocytopenia, radiotherapy and chemotherapy-induced cytopenia, qi and blood deficiency and kidney yang deficiency.

The invention relates to application of an acellular fat extracting solution to treatment of myelosuppression. Specifically, the invention provides an application of the cell-free fat extract, the cell-free fat extract is used for preparing a composition or a preparation, and the composition or the preparation is selected from one or more of the following applications: (i) prevention and / or treatment of myelosuppression; (ii) increasing the number of blood cells; and / or (iii) for the prevention or treatment of hemopenia. The cell-free fat extracting solution disclosed by the invention has an excellent treatment effect on myelosuppression and hemopenia.

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester in combination with G-CSF or in combination with EPO, are provided for the treatment of cytopenia in mammalian subjects. The compositions and methods also reduce the duration of cytopenia such as neutropenia, thrombocytopenia, and / or anemia.