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Application of cell-free fat extracting solution to treatment of myelosuppression

A technology of fat extraction and bone marrow suppression, which is applied in the fields of extracellular fluid diseases, application, blood diseases, etc., can solve the problems of increasing the suffering of tumor patients, and the side effects of anti-tumor bone marrow suppression cannot be effectively improved.

Pending Publication Date: 2022-05-10
SHANGHAI SEME CELL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing clinical anti-cancer treatment, due to the lack of effective drugs for the treatment of myelosuppression, the side effects of anti-tumor myelosuppression cannot be effectively improved, thus increasing the pain of cancer patients

Method used

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  • Application of cell-free fat extracting solution to treatment of myelosuppression
  • Application of cell-free fat extracting solution to treatment of myelosuppression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0284] Embodiment 1 examines the therapeutic effect of CEFFE on myelosuppression

[0285] 1. Experimental method

[0286] 1.1. Preparation of Cell free fat extract (CEFFE)

[0287] Fat was obtained from volunteers with informed consent. The preparation method of cell-free adipose tissue extract is as follows:

[0288] (1) Adipose tissue was obtained from 6 healthy women who underwent conventional liposuction, with an average age of 31 years (24-36 years). After local injection of tumescent fluid for anesthesia, use a 3mm liposuction cannula with a large side hole (2mm x 7mm) to connect to a 20mL syringe, draw radially under artificial negative pressure, stand the obtained fat upright, remove the tumescent fluid, and use Rinse with saline 3 times.

[0289] (2) The adipose tissue after rinsing was taken, placed in a centrifuge tube, and centrifuged at 1200 g at 4° C. for 3 minutes in a centrifuge to obtain a layered mixture.

[0290] (3) For the layered mixture, the upper o...

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Abstract

The invention relates to application of an acellular fat extracting solution to treatment of myelosuppression. Specifically, the invention provides an application of the cell-free fat extract, the cell-free fat extract is used for preparing a composition or a preparation, and the composition or the preparation is selected from one or more of the following applications: (i) prevention and / or treatment of myelosuppression; (ii) increasing the number of blood cells; and / or (iii) for the prevention or treatment of hemopenia. The cell-free fat extracting solution disclosed by the invention has an excellent treatment effect on myelosuppression and hemopenia.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the therapeutic application of cell-free fat extract to bone marrow suppression. Background technique [0002] Myelosuppression is a decrease in the activity of blood cell precursors in the bone marrow. Blood cells in the bloodstream are short-lived and often require constant replenishment. Stem cells, the precursors of blood cells, must divide rapidly for timely replenishment. [0003] Chemotherapy and radiation, as well as many other antineoplastic treatments, target rapidly dividing cells, often resulting in suppression of normal bone marrow cells. Bone marrow suppression is a common toxic reaction in tumor treatment. Cancer treatments such as chemotherapy and radiotherapy can cause different degrees of bone marrow suppression and reduce the number of peripheral blood cells. Blood cells are composed of multiple components, and each component plays an important role in the human body. ...

Claims

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Application Information

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IPC IPC(8): A61K35/35A61K45/06A61K31/675A61K31/664A61K31/198A61K31/196A61K31/4184A61K31/565A61P7/00A61P35/00A23L33/115
CPCA61K35/35A61K45/06A61K31/675A61K31/664A61K31/198A61K31/196A61K31/4184A61K31/565A61P7/00A61P35/00A23L33/115A23V2002/00A61K2300/00A23V2200/30A23V2200/306A23V2200/308
Inventor 张文杰侯曦凡
Owner SHANGHAI SEME CELL TECH CO LTD
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