76 results about "Dose reduction" patented technology

An apparatus for spatial modulation of an x-ray beam has a number of planar attenuation elements for x-ray radiation that are disposed in a grid on a carrier and can be pivoted or tilted by a piezoelectric actuator, independently of one another, between at least two positions. One or more sensors with which a piezoelectrically-caused length and / or width and / or position change of the piezoelectrically influenced regions can be detected, are arranged on piezoelectrically influenced regions of the attenuation elements or the actuators. A significant dose reduction and / or dynamic adjustment thereof can be achieved with the apparatus by image adaptation in many areas of x-ray imaging, since a precise determination of the position of each attenuation element in real time is enabled.

Substantial reduction of the radiation dose in computed tomography (CT) imaging is shown using a machine-learning dose-reduction technique. Techniques are provided that (1) enhance low-radiation dosage images, beyond just reducing noise, and (2) may be combined with other approaches, such as adaptive exposure techniques and iterative reconstruction, for radiation dose reduction.

The invention relates to the field of drug development against acute radiation injury caused by exposure to high-energy electromagnetic waves (X-rays, gamma rays) or particles (alpha particles, beta particles, neutrons). To date, there is no effective drug to ameliorate radiation injury after accidental exposure to ionizing irradiation. The invention provides a method of treating radiation injury of a subject in need thereof comprising administering to the subject a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids. Furthermore, the invention provides use of a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids for the production of a pharmaceutical composition for the treatment of a subject suffering from or believed to be suffering from radiation injury. In particular, the invention provides anti-radiation peptides having a dose reduction factor (DRF) against acute gamma irradiation of at least 1.10, said DRF determinable by testing which dose of radiation results in 50% mortality at 30 days (LD50 / 30) after whole body radiation (WBI) in a test group of mice treated with said peptide at 72 hours after WBI and, testing which dose of radiation results in 50% mortality at 30 days (LD50 / 30) after whole body radiation (WBI) in a control group of mice treated only with the vehicle of said peptide at 72 hours after WBI and wherein the DRF is calculated by dividing the LD50 / 30 of the peptide-treated animals by the LD50 / 30 of the vehicle-treated animals.