Use of catechin in preparing medication for preventing and/ or treating pancytopenia

A technology for hemocytopenia and catechins, applied to extracellular fluid diseases, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as high cost, clinical use restrictions, side effects, etc.

Inactive Publication Date: 2004-03-31
GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical drug treatment method to promote the recovery of hematopoietic function is to use genetically recombined hematopoietic cell growth factors (such as Epo, GM-CFS, etc.), but the cost is very expensive (patients need to spend 10,000 to 20,000 yuan / month), and there are Cause side effects of tumors and autoimmune diseases, clinical use is relatively limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Formula: 125 grams of catechins, 875 grams of medicinal starch

[0012] Put the above components into a blender, stir and mix well, pack capsules with a capsule machine, each capsule is filled with 1 gram, and 1000 catechin capsules are prepared, each capsule contains 125 mg of catechin.

Embodiment 2

[0014] Catechin 62.5g, distilled water 1000ml

[0015] Dissolve the catechin in distilled water, mix well, put it into glass bottles with a canning machine, each bottle is filled with 10 ml, and sterilize to prepare the catechin injection.

Embodiment 3

[0016] Example 3 Effect of the active ingredient catechin of Caulis Spatholobus on the proliferation of bone marrow-suppressed mouse hematopoietic progenitor cells

[0017] Materials and methods

[0018] Kunming mice, half male and half female, were randomly divided into normal group, control group (the mice were irradiated with 60CO γ-ray sublethal whole body without administration), catechin administration group (three dosage groups) , high dose 0.4mg.mL-1, medium dose 0.08mg.mL-1, low dose 0.016mg.mL-1). Except for the mice in the normal group, the rest of the mice were 60 CO γ-ray whole body sublethal radiation (irradiation rate 210.6 lun / min; irradiation dose 400 rads; irradiation time 1 minute 50.7 seconds), on the day after irradiation, the normal group and the control group took orally sterile water for injection, and the catechin group took orally Each dose was administered once a day for 21 consecutive days. On the 3rd, 7th, 14th, and 21st days after administratio...

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PUM

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Abstract

The new applications of catechin and epicatechin, espeically for preventing and / or treating panhematopenia. Catechin or epicatechin could effectively treat panhematopenia caused by various reasons. The mechanism is catechin and epicatechin can increase the number of hematopoietic stem cell / progenitor cell in mice with marrow hemopoiesis inhibition, promote proliferation and differentiation, and thus increase three strains of blood cells to normal levels

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly relates to the new application of catechin (catechin) and its isomer epicatechin (epicatechin) extracted from natural plants and / or obtained in chemical synthesis, and specifically relates to Their application in the preparation of medicines for treating pancytopenia (including white blood cells, red blood cells and platelets). technical background [0002] The research on catechins has been reported in the literature, and the reports on the therapeutic effects of catechins can be summarized as anti-cancer, scavenging oxygen free radicals, anti-oxidation, regulating immunity, anti-platelet aggregation, etc. [1-10] . But so far, there has been no application of catechin or epicatechin for the treatment of medicaments for pancytopenia (including white blood cells, red blood cells, and platelets). [0003] During the course of radiotherapy and chemotherapy for cancer patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P7/00
Inventor 刘屏陈若芸陈孟莉崔艳君王东晓
Owner GENERAL HOSPITAL OF PLA
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