Prevention and treatment device for peripheral neuropathy caused by chemotherapeutic drugs

Abstract

The invention relates to the technical field of chemotherapy auxiliary medical instruments, and discloses a prevention and treatment device for peripheral neuropathy caused by chemotherapy drugs, which comprises a control device and a palm sleeve which is sequentially provided with an inner layer, a temperature control layer, a heat insulation layer and an inflation layer from inside to outside, the inner layer is used for wrapping hands and / or feet, detecting the temperature and pressure of the skin of a patient and applying medium-frequency electrical stimulation to the skin of the patient, the temperature control layer is used for controlling the temperature of the skin of the patient, the heat insulation layer is used for keeping the temperature of the temperature control layer, and the inflation layer is used for pressurizing the skin of the patient. By arranging the inner layer, the temperature control layer and the inflation layer, the hand or the foot can be wrapped, temperature control and pressure control can be carried out on the hand or the foot of a patient through control of the control device so as to prevent chemotherapy-induced peripheral neuropathy, or intermediate-frequency electrical stimulation can be carried out so as to recover the chemotherapy-induced peripheral neuropathy, and due to the fact that the temperature and the pressure are controllable, the temperature and the pressure of the patient can be controlled. The effect, comfort and safety of preventing and treating the peripheral neuropathy caused by chemotherapy are better.

Description

Technical Field

[0001] The present application relates to the technical field of chemotherapy-assisted medical devices, and in particular to a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs. Background Art

[0002] Chemotherapy has become an important means of treating breast cancer. Chemotherapy-induced peripheral neuropathy (CIPN) refers to the damage of chemotherapy drugs to peripheral nerves and a series of symptoms and signs of neurological dysfunction.

[0003] Studies have shown that reducing peripheral blood perfusion at the extremities by installing pressure devices on both sides of gloves can partially prevent the occurrence of peripheral neuropathy. In addition, local ice cold therapy can also cause vasoconstriction, thereby limiting the circulation of drugs to the extremities, reducing the accumulation of drugs in the palms, soles and other parts, thereby reducing the incidence and severity of hand-foot syndrome. However, the temperature of cold therapy needs to be controlled. Complications may occur when the skin temperature is lower than 10°C, changes in nerve structure and function may occur when the temperature is lower than 7°C, and complete loss of motor and sensory functions when the temperature is lower than 5°C. Nerve necrosis may occur at 0°C. Therefore, if the temperature regulation of cold therapy cannot be effectively controlled, it is easy to produce effects opposite to the physiological effects.

[0004] In order to promote the recovery of damaged peripheral neuropathy, the expert consensus strongly recommends the use of traditional medicine such as oral or external application of Chinese medicine packs, acupuncture, moxibustion, electrical stimulation, etc. to stimulate bioelectric induction and meridian conduction signals, which can enhance the effects of promoting qi and unblocking meridians, promoting the flow of defensive qi, treating arthralgia, promoting nerve function recovery and improving patient symptoms or signs.

[0005] In current clinical practice, patients with chemotherapy-induced peripheral neuropathy often wear double-layer small gloves to apply pressure to their hands, or use ice gloves to reduce blood perfusion in the extremities, or wear cotton gloves to maintain local temperature. However, the above methods cannot achieve temperature and pressure control on the patient's hands or feet to prevent chemotherapy-induced peripheral neuropathy or perform electrical stimulation to restore chemotherapy-induced peripheral neuropathy. In addition, the temperature of ice gloves and cotton gloves is uncontrollable, which affects the effect of preventing and treating chemotherapy-induced peripheral neuropathy. They are also highly irritating and less safe and comfortable for patients to wear.

[0006] Therefore, the prior art still needs to be improved and developed, and lacks a preventive and therapeutic device that can prevent and restore chemotherapy-induced peripheral neuropathy. Summary of the invention

[0007] In view of the shortcomings of the prior art, the present invention can wrap the hands or feet by providing an inner layer, a temperature control layer, and an inflation layer. The control device can control the temperature and pressure of the patient's hands or feet to prevent chemotherapy-induced peripheral neuropathy, or perform medium-frequency electrical stimulation to restore chemotherapy-induced peripheral neuropathy. Since the temperature and pressure are controllable, the effect, comfort, and safety of preventing and treating chemotherapy-induced peripheral neuropathy are better.

[0008] In order to solve the above technical problems, the technical solution adopted by the present invention is as follows: a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs, comprising: a palm glove and a control device, the palm glove comprising: an inner layer, on which a plurality of temperature sensors, a plurality of pressure sensors and a plurality of electrodes are respectively arranged, the inner layer is used to wrap the hand and / or foot and detect the temperature and pressure of the patient's skin and apply medium-frequency electrical stimulation to the patient's skin;

[0009] A temperature control layer, which is sleeved on the inner layer and is provided with a temperature regulating unit, and is used to control the temperature of the patient's skin;

[0010] A heat-insulating layer, which is sleeved on the temperature-controlling layer and is used to keep the temperature-controlling layer warm;

[0011] An inflatable layer, which is sleeved on the temperature control layer and is used to apply pressure to the patient's skin;

[0012] A control device is provided separately from the inner layer, and is respectively connected to a plurality of the temperature sensors, a plurality of the pressure sensors, a plurality of the electrodes, the temperature regulating unit and the inflation layer.

[0013] Furthermore, a plurality of the temperature sensors and a plurality of the pressure sensors are respectively arranged corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient.

[0014] Further, the temperature sensor comprises: a thermal insulation pad, the inner layer is provided with a through hole, and the thermal insulation pad covers the through hole;

[0015] Two patch type temperature sensors are respectively arranged on two opposite surfaces of the thermal insulation pad.

[0016] Furthermore, several of the electrodes are arranged corresponding to the Zusanli, Fenglong, Hegu, Quchi, Xuehai and Sanyinjiao acupoints.

[0017] Furthermore, the temperature control layer includes: a waterproof layer, wherein a containing cavity is provided in the waterproof layer;

[0018] A hydrogel layer is disposed in the accommodating cavity, and the hydrogel layer is disposed corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient.

[0019] Further, the temperature regulating unit includes: a heating unit, the heating unit is electrically connected to the control device, and the heating unit is arranged in the hydrogel layer;

[0020] A semiconductor cooling sheet, wherein one end of the semiconductor cooling sheet facing away from the patient's skin penetrates the thermal insulation layer and is thermally connected to the air-filled layer, and one end of the semiconductor cooling sheet facing the patient's skin is thermally connected to the hydrogel layer.

[0021] Further, the control device includes: an air pump;

[0022] The electric control valve, the air pump, the inflation layer and the electric control valve are connected in sequence.

[0023] Furthermore, the prevention and treatment device also includes: a plurality of blood oxygen sensors and a plurality of pulse sensors, and the plurality of blood oxygen sensors and the plurality of pulse sensors are respectively arranged corresponding to the thumbs and / or toes of the patient.

[0024] Furthermore, the prevention and control device also includes: a restraining layer, which is sleeved on the inflatable layer and is used to limit the volume of the inflatable layer.

[0025] Furthermore, the prevention and treatment device also includes: a temperature-sensitive gel layer, the inner layer is sleeved on the temperature-sensitive gel layer, and the inner layer is detachably connected to the temperature-sensitive gel layer.

[0026] Beneficial effects: The present invention can wrap the hands or feet by providing an inner layer, a temperature control layer, and an inflation layer. The control device can control the temperature and pressure of the patient's hands or feet to prevent chemotherapy-induced peripheral neuropathy, or perform medium-frequency electrical stimulation to restore chemotherapy-induced peripheral neuropathy. Since the temperature and pressure are controllable, the effect, comfort, and safety of preventing and treating chemotherapy-induced peripheral neuropathy are better. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 A schematic diagram of the structure of the device for preventing and treating peripheral neuropathy caused by chemotherapy drugs provided by the present invention;

[0028] Figure 2 A cross-sectional view of the device for preventing and treating peripheral neuropathy caused by chemotherapy drugs provided by the present invention (without the temperature-sensitive gel layer installed);

[0029] Figure 3 A cross-sectional view of a temperature sensor provided by the present invention;

[0030] Figure 4 A cross-sectional view of a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs (installed with a temperature-sensitive gel layer) provided by the present invention;

[0031] Figure 5 For the present invention Figure 4 A local enlarged structural schematic diagram of A;

[0032] Figure 6 A cross-sectional view of a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs (installed with a temperature-sensitive gel layer) provided by the present invention;

[0033] Figure 7 A cross-sectional view of a temperature adjustment unit provided by the present invention.

[0034] The markings in the accompanying drawings are: 100, palm cover; 110, inner layer; 111, temperature sensor; 111a, thermal insulation pad; 111b, patch temperature sensor; 112, pressure sensor; 113, electrode; 114, blood oxygen sensor; 115, pulse sensor; 120, temperature control layer; 121, temperature adjustment unit; 121a, heating unit; 121b, semiconductor refrigeration sheet; 130, thermal insulation layer; 140, inflation layer; 150, temperature-sensitive gel layer; 200, control device; 210, connection port. DETAILED DESCRIPTION

[0035] The present invention provides a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs. In order to make the purpose, technical scheme and effect of the present invention clearer and more specific, the present invention is further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0036] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it can be directly on the other component or indirectly on the other component. When a component is referred to as being "connected to" another component, it can be directly connected to the other component or indirectly connected to the other component.

[0037] It should also be noted that the same or similar numbers in the drawings of the embodiments of the present invention correspond to the same or similar parts; in the description of the present invention, it should be understood that if the terms "upper", "lower", "left", "right" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, it is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction. Therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and cannot be understood as limitations on this patent. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to specific circumstances.

[0038] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0039] The invention is further described below by describing embodiments in conjunction with the accompanying drawings.

[0040] This embodiment provides a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs, such as Figures 1 to 7 As shown in , in order to solve the above technical problems, the technical solution adopted by the present invention is as follows: it includes a palm cuff 100 and a control device 200, the palm cuff 100 is used to be worn on the patient's hands and / or feet, and the control device 200 is electrically and pneumatically connected to the palm cuff 100 to control the palm cuff 100.

[0041] The palm glove 100 includes: an inner layer 110, a temperature control layer 120, a heat insulation layer 130 and an air-filled layer 140. The inner layer 110 is used to wrap the hands and / or feet. The temperature control layer 120 is sleeved on the inner layer 110, the heat insulation layer 130 is sleeved on the temperature control layer 120, and the air-filled layer 140 is sleeved on the temperature control layer 120. The inner layer 110, the temperature control layer 120, the heat insulation layer 130 and the air-filled layer 140 form the shape of a glove or a sock. Preferably, a plurality of palm glove 100 are provided, and the plurality of palm glove 100 are connected to the control device 200. Preferably, the inner layer 110 and the temperature control layer 120 can be adhered to each other to reduce thermal resistance, and the temperature control layer 120 and the heat insulation layer 130 can be partially adhered to increase thermal resistance.

[0042] The inner layer 110 is respectively provided with a plurality of temperature sensors 111, a plurality of pressure sensors 112 and a plurality of electrodes 113, and the inner layer 110 is used to detect the temperature and pressure of the patient's skin and to apply medium-frequency electrical stimulation to the patient's skin. Specifically, medium-frequency electrical stimulation can be performed on certain parts of the patient through a plurality of electrodes 113 to restore chemotherapy-induced peripheral neuropathy. Preferably, the inner layer 110 is made of a flexible material with good thermal conductivity and poor electrical conductivity, such as silicone or a silicone material with diamond powder, aluminum nitride, aluminum oxide, boron nitride and / or zinc oxide fillers added thereto. The temperature sensor 111, the pressure sensor 112 and the electrode 113 are all flexible thin sheets, and the temperature sensor 111, the pressure sensor 112 and the electrode 113 are all embedded in the inner layer 110, and are integrated to avoid the protrusions affecting the wearing comfort of the patient.

[0043] The temperature control layer 120 is provided with a temperature regulating unit 121, the temperature control layer 120 is used to control the temperature of the patient's skin, the heat insulating layer 130 is used to keep the temperature control layer 120 warm, and the air-filled layer 140 is used to pressurize the patient's skin. Specifically, the temperature of the patient's hands or feet is controlled by the temperature regulating unit 121, and the pressure of the patient's hands or feet is controlled by the air-filled layer 140, so as to prevent chemotherapy-induced peripheral neuropathy.

[0044] The control device 200 is separately arranged from the inner layer 110 , and is respectively connected to a plurality of temperature sensors 111 , a plurality of pressure sensors 112 , a plurality of electrodes 113 , a temperature regulating unit 121 and an inflation layer 140 , and is connected to the palm glove via a plurality of connection ports 210 . Specifically, a temperature adjustment knob is provided on the panel of the control device 200, and a circuit of a temperature adjustment unit 121 is provided in the control device 200. The operation of the temperature adjustment unit 121 is controlled by feedback from a plurality of temperature sensors 111, so that the temperatures measured by the plurality of temperature sensors 111 are close to the temperature values ​​preset by the temperature adjustment knob; a pressure adjustment knob is provided on the panel of the control device 200, and a pressure adjustment device and a control circuit, such as an air pump, are provided in the control device 200. The operation of the air pump is controlled by feedback from a plurality of pressure sensors 112 to change the air pressure of the inflation layer 140, so that the pressures measured by the plurality of pressure sensors 112 are close to the pressure values ​​preset by the pressure adjustment knob; frequency, pulse width, amplitude and treatment time adjustment knobs are provided on the panel of the control device 200, and an adjustable intermediate frequency electrical stimulation generator is provided in the control device 200, and the intermediate frequency electrical stimulation generator operates according to the values ​​preset by the frequency, pulse width, amplitude and treatment time adjustment knobs. The voltage control, heating and adjustable medium frequency electrical stimulation generator are all integrated into a square device, which has the advantage of convenience.

[0045] In one embodiment, Figure 2As shown in , several temperature sensors 111 and several pressure sensors 112 are respectively set corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient. Specifically, the control device 200 is electrically connected to the several temperature sensors 111 and the several pressure sensors 112 respectively. The control device 200 can detect the temperature of the back of the hand, the side of the palm, the back of the foot, and the side of the foot through the several temperature sensors 111. Through the feedback of the several temperature sensors 111, the temperature adjustment unit 121 can be accurately regulated, thereby realizing accurate control of the temperature of the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient; the control device 200 can detect the pressure of the back of the hand, the side of the palm, the back of the foot, and the side of the foot through the several pressure sensors 112. Through the feedback of the several pressure sensors 112, the air pressure of the inflation layer 140 can be accurately regulated, thereby realizing accurate control of the pressure of the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient.

[0046] In one embodiment, Figure 2 , Figure 3 As shown in , the temperature sensor 111 includes: a heat insulating pad 111a and two patch temperature sensors 111b. A through hole is provided on the inner layer 110, the heat insulating pad 111a covers the through hole, and the two patch temperature sensors 111b are respectively provided on two opposite surfaces of the heat insulating pad 111a.

[0047] Specifically, the two patch temperature sensors 111b are used to detect the temperature of the corresponding parts of the patient's skin and the temperature of the temperature control layer 120 respectively. The numerical insulation pad 111a can reduce the influence of the temperature between the two. The patch temperature sensor 111b facing the temperature of the temperature control layer 120 can provide feedback to the control device 200, so that the temperature of the temperature control layer 120 can be better adjusted. Preferably, the temperature sensors 111 corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient do not include the insulation pad 111a, which can be used to detect the temperature of the corresponding position of the patient, so as not to reduce the effect of the temperature control layer 120 on the patient's skin. However, the temperature sensors 111 located outside the above-mentioned parts include the insulation pad 111a, which can better detect the temperature of the temperature control layer 120.

[0048] In one embodiment, Figure 2 As shown in FIG, a plurality of electrodes 113 are arranged corresponding to the acupuncture points of Zusanli, Fenglong, Hegu, Quchi, Xuehai and Sanyinjiao.

[0049] In one embodiment, the temperature control layer 120 includes: a waterproof layer and a hydrogel layer, a containing cavity is provided in the waterproof layer, the hydrogel layer is provided in the containing cavity, and the hydrogel layer is provided corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient. Accurately controlling the temperature and pressure of the back of the hand, the side of the palm, the back of the foot, and the side of the foot can effectively prevent chemotherapy-induced peripheral neuropathy. Preferably, the hydrogel layer covers the entire hand and / or foot, and the area except the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the corresponding patient is covered with a heat insulation pad 111a. Preferably, a plurality of through holes are provided on the heat insulation pad 111a, and the heat transfer rate between the hydrogel layer and the patient's skin can be changed by changing the density and size of the through holes. Preferably, the hydrogel layer is a mixture of hydrogel and water.

[0050] In one embodiment, Figure 6 , Figure 7 As shown in , the temperature regulating unit 121 includes: a heating unit 121a and a semiconductor cooling sheet 121b, the heating unit 121a is electrically connected to the control device 200, the heating unit 121a is arranged in the hydrogel layer, the end of the semiconductor cooling sheet 121b away from the patient's skin penetrates the insulation layer 130 and is thermally connected to the gas-filled layer 140, and the end of the semiconductor cooling sheet 121b facing the patient's skin is thermally connected to the hydrogel layer. Preferably, the hydrogel layer is arranged in an integrated manner, and the heating unit 121a or the semiconductor cooling sheet 121b can heat or cool the entire hydrogel layer when working, and the overall temperature of the hydrogel layer is uniform, which can increase the comfort of the patient when wearing it.

[0051] In one embodiment, the control device 200 includes: an air pump and an electric control valve, and the air pump, the air-filled layer 140 and the electric control valve are connected in sequence. When the air pressure of the air-filled layer 140 needs to be increased, the control device 200 controls the air pump to work and the electric control valve to close or shrink.

[0052] It is understandable that when the air pump is working and the electric control valve is not closed, the airflow will flow from the air pump to the gas-filled layer 140 and then leave the electric control valve. At this time, if the semiconductor refrigeration sheet 121b is cooling, its cooling end is thermally connected to the hydrogel layer to cool the hydrogel layer, and its heat dissipation end is thermally connected to the gas-filled layer 140 to take away the heat through the airflow; at this time, if the semiconductor refrigeration sheet 121b is heating, its heating end is thermally connected to the hydrogel layer to heat the hydrogel layer, and its cooling end is thermally connected to the gas-filled layer 140 to absorb the heat in the airflow. This structure can reduce the volume of the heat dissipation structure, reduce the weight of the palm cover 100, and improve the wearing experience of the patient. Preferably, the control device 200 is provided with a device that can cool or heat the gas blown out by the air pump. When the semiconductor refrigeration sheet 121b cools the hydrogel layer, the control device 200 cools the gas blown out by the air pump; when the semiconductor refrigeration sheet 121b heats the hydrogel layer, the control device 200 heats the gas blown out by the air pump to improve the efficiency and rate of cooling and heating the hydrogel layer by the semiconductor refrigeration sheet 121b.

[0053] In one embodiment, Figure 2 As shown in , the prevention and treatment device also includes: a plurality of blood oxygen sensors 114 and a plurality of pulse sensors 115, and the plurality of blood oxygen sensors 114 and the plurality of pulse sensors 115 are respectively arranged corresponding to the thumbs and / or toes of the patient.

[0054] Preferably, the blood oxygen sensor 114 and the pulse sensor 115 are both photoelectric sensors. The specific structure and principle can refer to the existing smart bracelets or smart watches that can measure blood oxygen and pulse. The blood oxygen sensor 114 and the pulse sensor 115 can monitor the pulse, oxygen saturation and other microcirculation indicators at the fingertips or feet in real time, and provide real-time feedback to the control device 200 for temperature and pressure regulation to prevent numbness of the hands and feet from causing insensitivity to temperature and pressure, and the possibility of frostbite, burns and pressure injuries.

[0055] In one embodiment, the prevention and treatment device further includes: a tie layer, which is sleeved on the inflatable layer 140, and the tie layer is used to limit the volume of the inflatable layer 140. Specifically, the inflatable layer 140 can be made of a material with good elasticity such as a balloon or a tire inner tube, and the tie layer can be made of a material with good tensile resistance such as a nylon limiter. The tie layer and the inflatable layer 140 can be partially bonded. When the air pressure of the inflatable layer 140 increases and the volume expands, since the space in the tie layer remains unchanged or changes slightly, the inflatable layer 140 will be compressed inward to apply pressure to the hands or feet.

[0056] In one embodiment, Figure 4 , Figure 5As shown in , the prevention and treatment device also includes: a temperature-sensitive gel layer 150, the inner layer 110 is sleeved on the temperature-sensitive gel layer 150, and the inner layer 110 and the temperature-sensitive gel layer 150 are detachably connected.

[0057] Specifically, the thermosensitive gel patch 150 is made of thermosensitive water-based polymer materials, Chinese medicine extracts, glycerin, borneol and other materials. The thermosensitive water-based polymer material is polymerized by N-isopropyl acrylamide, N-hydroxymethyl acrylamide and methacrylic acid, and its lower critical solution temperature is 30-40°C. The thermosensitive Chinese medicine gel patch utilizes the characteristic that the swelling state of the thermosensitive hydrogel colloid changes suddenly near the critical temperature value, which effectively improves the release of drug ingredients. It is used in conjunction with the temperature control layer 120 to maximize the release of the efficacy of the Chinese medicine package.

[0058] In summary, the present application relates to the technical field of chemotherapy-assisted medical devices, and discloses a device for preventing and treating peripheral neuropathy caused by chemotherapy drugs, which includes a control device and a palm sleeve having an inner layer, a temperature control layer, a heat insulating layer, and an air-filled layer arranged in sequence from the inside to the outside, wherein the inner layer is used to wrap the hands and / or feet and detect the temperature and pressure of the patient's skin and apply medium-frequency electrical stimulation to the patient's skin, the temperature control layer is used to control the temperature of the patient's skin, the heat insulating layer is used to keep the temperature control layer warm, and the air-filled layer is used to pressurize the patient's skin. The present invention can wrap the hands or feet by arranging the inner layer, the temperature control layer, and the air-filled layer, and can control the temperature and pressure of the patient's hands or feet through the control of the control device to prevent chemotherapy-induced peripheral neuropathy, or perform medium-frequency electrical stimulation to restore chemotherapy-induced peripheral neuropathy. Since the temperature and pressure are controllable, the effect, comfort, and safety of preventing and treating chemotherapy-induced peripheral neuropathy are better.

[0059] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A device for preventing and treating peripheral neuropathy caused by chemotherapy drugs, characterized in that: include: A palm glove and a control device, the palm glove comprising: an inner layer, on which are respectively provided a plurality of temperature sensors, a plurality of pressure sensors and a plurality of electrodes, the inner layer being used to wrap the hand and / or foot and detect the temperature and pressure of the patient's skin and apply medium-frequency electrical stimulation to the patient's skin; A temperature control layer, which is sleeved on the inner layer and is provided with a temperature regulating unit, and is used to control the temperature of the patient's skin; A heat-insulating layer, which is sleeved on the temperature-controlling layer and is used to keep the temperature-controlling layer warm; An inflatable layer, which is sleeved on the temperature control layer and is used to apply pressure to the patient's skin; The control device is arranged separately from the inner layer, and the control device is respectively connected with a plurality of the temperature sensors, a plurality of the pressure sensors, a plurality of the electrodes, the temperature regulating unit and the inflation layer.

2. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 1, characterized in that: The plurality of temperature sensors and the plurality of pressure sensors are respectively arranged corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient.

3. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 2, characterized in that: The temperature sensor comprises: a heat insulating pad, the inner layer is provided with a through hole, and the heat insulating pad covers the through hole; Two patch type temperature sensors are respectively arranged on two opposite surfaces of the thermal insulation pad.

4. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 1, characterized in that: Several of the electrodes are arranged corresponding to the acupuncture points of Zusanli, Fenglong, Hegu, Quchi, Xuehai and Sanyinjiao.

5. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 1, characterized in that: The temperature control layer comprises: a waterproof layer, wherein a containing cavity is arranged in the waterproof layer; A hydrogel layer is disposed in the accommodating cavity, and the hydrogel layer is disposed corresponding to the back of the hand, the side of the palm, the back of the foot, and the side of the foot of the patient.

6. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 5, characterized in that: The temperature regulating unit comprises: a heating unit, the heating unit is electrically connected to the control device, and the heating unit is arranged in the hydrogel layer; A semiconductor cooling sheet, wherein one end of the semiconductor cooling sheet facing away from the patient's skin penetrates the thermal insulation layer and is thermally connected to the air-filled layer, and one end of the semiconductor cooling sheet facing the patient's skin is thermally connected to the hydrogel layer.

7. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 6, characterized in that: The control device comprises: an air pump; The electric control valve, the air pump, the inflation layer and the electric control valve are connected in sequence.

8. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 1, characterized in that: The prevention and treatment device further comprises: a plurality of blood oxygen sensors and a plurality of pulse sensors, wherein the plurality of blood oxygen sensors and the plurality of pulse sensors are respectively arranged corresponding to the thumbs and / or toes of the patient.

9. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to claim 1, characterized in that: The prevention and control device further comprises: a restraining layer, wherein the restraining layer is sleeved on the inflatable layer, and the restraining layer is used to limit the volume of the inflatable layer.

10. The device for preventing and treating peripheral neuropathy caused by chemotherapy drugs according to any one of claims 1 to 9, characterized in that: The prevention and treatment device further comprises: a temperature-sensitive gel layer, the inner layer is sleeved on the temperature-sensitive gel layer, and the inner layer is detachably connected to the temperature-sensitive gel layer.

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