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Infant formulas contg. long-chain polyunsaturated fatty acids and uses thereof

An infant formula and fatty acid technology, applied in the field of nutritional formula, can solve problems such as insufficient full-process synthesis, limited supply, and slow growth

Inactive Publication Date: 2003-08-13
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Third, supply is also limited by insufficient full-course synthesis of AA and DHA derived from their dietary essential precursor fatty acids linoleic acid (18:2n-6) and alpha-linolenic acid (18:3n-3), respectively.
A third study (Ryan et al. 1998) showed slower growth in preterm infants fed DHA-containing preterm formula for two months after hospital discharge followed by four months of DHA-containing term formula
Lucas et al. (1992) demonstrated a substantial increase in linear growth and gain in preterm infants fed a nutritionally fortified formula up to 9 months CA, which was greater than in preterm infants fed a formula designed for term infants. Got results but no formula with DHA or AA
[0007] Also, no research data have been produced to try to control for possible interference from the home environment and maternal intelligence

Method used

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  • Infant formulas contg. long-chain polyunsaturated fatty acids and uses thereof
  • Infant formulas contg. long-chain polyunsaturated fatty acids and uses thereof
  • Infant formulas contg. long-chain polyunsaturated fatty acids and uses thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Embodiment 1: clinical research 1.1 research sample selection

[0138] Four hundred and seventy preterm infants ( grade II, maternal insufficiency including maternal cocaine or alcohol abuse or both during pregnancy, extracorporeal membrane oxidation, fluid ventilation, asphyxia due to severe and permanent neurological injury , or have uncontrolled systemic infection at the time of enrollment. In addition to the criteria of registration within 72 hours of the first enteral feeding, 8% of the subjects were registered outside this specified window, and 99% of the study subjects met all the specified entry and exclusion criteria. 1.2 Experimental design

[0139] 1.2.1 Research formula

[0140] According to the conventional process mentioned above, the nutrient-enriched formula containing DHA and AA was prepared. Modified formulations of SIMILAC SPECIAL CARE (type 1) and SIMILAC NEOSURE (type II) used in the present study differed from the formulations of ...

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PUM

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Abstract

Methods for providing nutrition and for enhancing neurological development of preterm infants are disclosed. Also disclosed is an improved nutritional composition containing specified amounts of DHA and AA as well as their precursor essential fatty acids alpha-linolenic and linoleic acids. The methods involve feeding LCP supplemented, nutrient-enriched formulas for an extended feeding regimen, typically until at least 3 months corrected age (CA), preferably to 6 or even 12 months CA. The neurological developments, for example, visual development, motor development and language development were enhanced without findings of anthropometric growth faltering or inhibition.

Description

[0001] The present invention relates to nutritional formulas, in particular to fortified infant formulas containing long-chain polyunsaturated fatty acids (LCP or LC-PUFA); and to methods of using such formulas to improve neurodevelopment in infants, particularly premature infants. method. [0002] This application is related to the abandoned Provisional Patent Application Serial No. 60 / 196970 filed April 13,2000. Background technique [0003] LCPs, including arachidonic acid ("AA", 20:4n-6) and / or docosahexaenoic acid ("DHA", 22:6n-3), should be added to formula whether or not intended for premature infants. ), which has become one of the hottest things in infant nutrition right now. After a few steps of reasoning it is conceivable that preterm infants fed infant formula without AA and DHA would have a substantially increased chance of developing suboptimal blood and tissue levels of these fatty acids compared to term infants. First, the accumulati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/00A23L1/30A23L33/00A61K31/201A61K31/202A61P27/02
CPCA23V2002/00A23L1/3008A23L1/296A23L33/40A23L33/12A61P25/00A61P27/02A61P3/02A61P43/00A23V2200/322A23V2250/1862A23V2250/1868A23V2250/1872A23V2250/1874A23V2250/187A23V2250/211A23V2250/712A23L33/21
Inventor D·L·奥康诺N·奥埃斯塔R·J·梅里特K·费茨格拉尔德-古斯塔夫森R·哈尔特J·亚诺夫斯基M·纽林格L·T·辛格
Owner ABBOTT LAB INC
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